Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing폐 질환 네트워크는 SARS-COV-2 감염에 대한 동반 질환의 영향과 약물 용도의 기회를 보여줍니다.Research Article Published on 2021-09-172022-08-31 Journal: BMC Medical Genomics [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] accelerate Algorithm Analysis approach association biological processes build Care clinical condition clinical conditions clinical evidence Community Comorbidity COVID-19 COVID-19 patient COVID-19 patients disease Disease network disorder drug Drug development functional functional protein genetic association Health Health care Health care system identify IMPROVE Lung disease Lung diseases lung disorder lung disorders Lungs molecular basis molecular feature Mortality overlap overlapped overlapping Pathway enrichment analysis Patient possession Protein Protein–protein interaction reason for respiratory Respiratory disease respiratory diseases Result reveal SARS-CoV-2 SARS-COV-2 infection similarity supplementary material target targets virus was used with COVID-19 [DOI] 10.1186/s12920-021-01079-7 PMC 바로가기 [Article Type] Research Article
Physiopathology and prospectives for therapeutic treatment of pulmonary fibrotic state in COVID-19 patientsShort communication Published on 2021-09-162022-10-05 Journal: Current Research in Pharmacology and Drug Discovery [Category] 치료법, [키워드] accelerate caused complications of COVID-19 COVID-19 COVID-19 infection COVID-19 patient cured deaths Fibrotic global pandemic indicated individuals Infection Lung function lung lesion mechanism pandemic Pharmacology Pneumonia pulmonary representing Severe case Therapeutic treatment tissue treat Treatment Vaccine viral damage viral infection [DOI] 10.1016/j.crphar.2021.100056 [Article Type] Short communication
Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 PatientsReview Published on 2021-09-092022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] accelerate accompanied Adaptive immune response Adaptive immunity age aging antioxidant antioxidants antiviral activity antiviral immunity Asymptomatic Comorbidities coronavirus disease COVID-19 COVID-19 symptom Cytokine storm deficiency dendritic cell determinant disease distress dysregulation Elderly patient Healthcare system heterogeneous Illness severity immune function Immunosuppression Infection Inflammation Inflammatory inflammatory immune response inhibiting viral replication Innate immunity interferon Macrophage Mild molecular mechanism outcomes oxidative oxidative stress pandemic pathophysiological progression response resulting resveratrol risk SARS-CoV-2 SARS-COV-2 infection Sex Symptoms the patient Treatment viral infections [DOI] 10.3390/antiox10091440 PMC 바로가기 [Article Type] Review
Rapid diagnosis of SARS-CoV-2 pneumonia on lower respiratory tract specimensResearch Article Published on 2021-09-082022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] accelerate Accuracy BAL BAS Bronchoalveolar lavage Bronchoalveolar lavage (BAL) Bronchoaspirates (BAS) can be used Characteristics clinical setting collected cycle threshold Cycle threshold value demographic diagnosis of SARS-CoV-2 diagnostic diagnostic tests distribution E gene evaluate expected feasible Germany Inc. intensive care unit intensive care units IQR Italy Lower respiratory tract LRT median molecular negative NPV PCR PCR assay Pneumonia positive PPV Predictive proportion Rapid Rapid PCR Result RT-PCR RT-PCR testing Sample size SARS-CoV-2 SARS-CoV-2 pandemic sensitivity solution South Korea specificity specimen specimens table tested threshold variables Viral load viral loads was used were expressed [DOI] 10.1186/s12879-021-06591-w PMC 바로가기 [Article Type] Research Article
DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M pro inhibitors410 Published on 2021-09-072022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] accelerate acute respiratory syndrome Antiviral applied bind Compound coronavirus covalent inhibitors COVID-19 COVID-19 pandemic Critical drug Drug discovery Efficacy food Human identify in vitro infectious agents inhibitor inhibitory activity initial M pro molecular weight producing protease Proteases Region SARS-CoV-2 screening method selective Significance sluggish small molecule specificity target targets the SARS-CoV-2 therapeutic time-consuming Traditional Treatment viral disease Viral protein viruses [DOI] 10.1073/pnas.2111172118 PMC 바로가기 [Article Type] 410
Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019Articles Published on 2021-09-042022-10-30 Journal: Lancet (London, England) [Category] Coronavirus, MERS, SARS, [키워드] accelerate access age all-cause mortality Analysis Asia burden Care cause-specific mortality children country COVID-19 COVID-19 pandemic death declined development Diseases Effect effort equity Factor females finding foundation fraction funding Goal group health system IMPROVE improvement include index Infection prevention Intervention less lowest maintain malaria male Melinda Gate Metrics Mortality mortality rate multiple scenario National Neonatal Neonatal disorder Neonatal Mortality Neonate Newborn NMR Probability Quality reduced reduction remained required respiratory infections scenario Sex statistically significant difference sub-Saharan Africa survival targets threshold Trajectories trajectory vaccination widespread [DOI] 10.1016/S0140-6736(21)01207-1 PMC 바로가기 [Article Type] Articles
QIBA guidance: Computed tomography imaging for COVID-19 quantitative imaging applicationsQIBA 지침: COVID-19 정량적 영상 애플리케이션을 위한 컴퓨터 단층 촬영 영상Article Published on 2021-09-012022-09-11 Journal: Clinical imaging [Category] MERS, SARS, 바이오마커, [키워드] accelerate acquisition Algorithm Algorithms Alliance artificial artificial intelligence assist best Biomarkers Committee Community Computed tomography computer vision conditions country COVID-19 COVID-19 pandemic Critical dataset density differential diagnosis disease Guidance help identify imaging Impact include International Lung CT Lung imaging Lung Nodule nodule North America open Patient care populations predict profile provide provided Quantitative Quantitative imaging Quantitative imaging. recommendation Research respiratory robust severity Society tomography trajectory [DOI] 10.1016/j.clinimag.2021.02.017 PMC 바로가기 [Article Type] Article
Development of leading first-generation vaccines against SARS-CoV-2Mini review Published on 2021-09-012022-10-05 Journal: Microbes and infection [Category] SARS, 비임상, [키워드] accelerate animal models clinical trial clinical trials COVID-19 development effective Immunity individual late phase pandemic required Safe SARS-CoV-2 Vaccine Vaccines [DOI] 10.1016/j.micinf.2021.104841 [Article Type] Mini review
Post-viral effects of COVID-19 in the olfactory system and their implications후각 시스템에 대한 COVID-19의 바이러스 후 영향 및 그 의미Review Published on 2021-09-012022-09-12 Journal: The Lancet. Neurology [Category] 진단, [키워드] accelerate acute phase Autopsy Brain brain region chemosensory clinical CNS Course COVID-19 Critical disease Effect evaluate Evidence Glia histological histopathological identify impair impairment implication Infection infection control Inflammation Inflammatory knowledge likelihood localised inflammation marker mechanism molecular molecular data nasal neurodegenerative neurodegenerative disorder Neuroimaging neurological Neurological deficit Neurological disease Neuron olfactory olfactory bulb olfactory dysfunction Olfactory epithelium patients with COVID-19 persistent Prevalence prognostic progression provide radiological recent replication of SARS-CoV-2 Research risk SARS-CoV-2 SARS-COV-2 infection small sample size specimen Spread structures subset symptomatic Trial upper respiratory viral infection virus [DOI] 10.1016/S1474-4422(21)00182-4 PMC 바로가기 [Article Type] Review
AI-driven multiscale simulations illuminate mechanisms of SARS-CoV-2 spike dynamicsSpecial Issue Papers Published on 2021-09-012022-10-29 Journal: The International Journal of High Performance Computing Applications [Category] COVID-19, [키워드] accelerate AI Complete complex computational virology conformational COVID19 deep learning develop flexible glycan GPU heterogeneous HPC human ACE2 receptor Interaction mechanism modulating molecular molecular dynamics multiscale simulation resource SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 viral Spike protein Summit the SARS-CoV-2 variety viral infection virus weighted ensemble [DOI] 10.1177/10943420211006452 PMC 바로가기 [Article Type] Special Issue Papers