activating – Page 19 – Communicable Diseases Research

Coronavirus-induced ER stress response and its involvement in regulation of coronavirus–host interactions

Article

Published on 2014-10-072022-11-01
Journal: Virus research
[Category] Coronavirus,

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

Research Article

Published on 2014-08-142022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] activate activating Activation acute respiratory syndrome addition administration analyses assays caused Cell cellular complementary confocal microscopy coronavirus cytoplasm decrease decreased expression Deleterious demonstrated determinant domain E protein Elimination envelope Epidemic exacerbated functional genetics highlight immune response immunopathology in vivo increase in induce infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibitor interact Interaction interactions involved lung lung damage MAPK mice modulating Mortality motif nucleus overexpression parental pathway potential therapeutic target Protein Proteins proteomic recombinant reduce reduction in respiratory SARS-CoV SARS-CoV E SARS-CoV infected cells SARS-CoV infection siRNA survival triggered triggering virulence virus virus virus attenuation was reduced yeast
[DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article

Coronavirus virulence genes with main focus on SARS-CoV envelope gene

Article

Published on 2014-08-022022-11-01
Journal: Virus research
[Category] Coronavirus,

[키워드] activated activated T cell activating Activation acute respiratory distress Adaptive immune response addressed Affect animal model antagonist Apoptosis ARDS attenuate B cell binding cause cellular cellular pathway coronavirus coronavirus CoV CoV genome CoV infection CoV protein cytokine death deleted deletion mutant described disease disease severity domain driver E protein edema elicit elicited envelope gene envelope protein exacerbated Host Host immune response humans IFN immune response immunopathological induce Infection inflammasome activation Inflammation Inflammatory response influence inhibiting innate immune responses innate immune system Innate immunity Interaction interferon interferon regulatory factor involved lung parenchyma manuscript MERS-CoV MHV mice Modification motif NF-κB NF-κB pathway nuclear Pathogenesis pathogenic pathogenicity pathway patients priming proinflammatory Proinflammatory cytokine promote proportion Protein Regulation Replication responses responsible SARS-CoV SARS-CoV E sequence shown Signaling signaling pathway Stress subgenomic mRNA synthesis syndrome TGEV transcription factor transmembrane transmembrane domain triggered vaccine candidates viral infections Viral protein virulence virulence gene virus virus virus infection
[DOI] 10.1016/j.virusres.2014.07.024 PMC 바로가기 [Article Type] Article

Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway

리보솜 단백질 돌연변이는 인슐린 경로의 S6 키나제 억제를 통해 자가포식을 유도합니다

Research Article

Published on 2014-05-292022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major activated activating Activation affected affecting AKT Anemia antioxidant aplasia autophagy Blood blood cell Blood cells Bone marrow bone marrow failure Catabolism CD34 Cell cellular conserved Critical cytopenia deregulation disease Embryo etiology event example explanation feature Genes growth growth defects Hematopoiesis impair impairment include increase increase in induce inhibit inhibition insulin insulin resistance insulin-signaling pathway involved kinase lead maturation mechanism Mutation observé opens oxygen p53 pathophysiology pathway Pathways Patient patients phenotype Phenotypes Phosphorylation Potential treatment progenitor cell promote provide reactive oxygen species reactive oxygen specy red blood cell red blood cells Red cell red cell aplasia reduce regulated ribosomal protein ribosome ROS RPS19 SDS Shwachman-Diamond syndrome Signaling signaling pathway Treatment triggered Tumor tumor suppressor while zebrafish
[DOI] 10.1371/journal.pgen.1004371 PMC 바로가기 [Article Type] Research Article

Global Analysis of the Sporulation Pathway of Clostridium difficile

Clostridium difficile의 포자 형성 경로에 대한 글로벌 분석

Research Article

Published on 2013-08-082022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activated activating Activation Analysis Antibiotics Author B. subtilis Bacillus subtilis Clostridia Clostridium Clostridium difficile Colitis Complication determine determined diagnostic biomarker Diagnostic biomarkers diarrhea expression Factor firmicutes framework function Gene gene product Genes genes encoding gram highlight identify Infection infectious infectious diarrhea lead life-threatening loss-of-function mutation loss-of-function mutations mechanism mutant organism pathogen Pathogenesis performed predicted provide pseudomembranous colitis question recurrence regulate regulated Regulatory regulatory pathway related required responsible Sequencing sigma spore spores sporulation Spread the United State Transcription transcriptional Transmission treat United States whole-genome
[DOI] 10.1371/journal.pgen.1003660 PMC 바로가기 [Article Type] Research Article

Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory viruses

Article

Published on 2013-04-292022-11-01
Journal: Virus research
[Category] Coronavirus, 신종인플루엔자,

[키워드] activating alveolar cell alveolar epithelial cell alveolar epithelial cells ATII Cell cell type cells contribute coronavirus correlated Critical Culture cytokine cytokine expression cytokine response Cytokines determine determined different disease severity epithelial cell exhibited Express expression Factor H1N1 Host IAV identify IL-1β immune responses in vitro model in vivo increased expression Infected Infection influenza A influenza A virus lung Lungs maintain Mouse-adapted SARS-coronavirus mouse-adapted SARS-CoV mRNA murine murine coronavirus murine model Pathogenesis pathology phenotype quantified respiratory viral infection respiratory virus respiratory viruses response robust SARS-CoV severe spread to susceptibility susceptible target type I Type I pneumocyte Type II pneumocyte v2163 viral infection viral infections viral pathogenesis virus viruses while
[DOI] 10.1016/j.virusres.2013.04.008 PMC 바로가기 [Article Type] Article

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

Research Article

Published on 2011-10-202022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] absence activating Activation acute respiratory syndrome addition alleviate Apoptosis apoptotic Author Cell cell metabolism cell stress cells compared contribute contributed control cell different dissemination down-regulated drug drugs E gene E protein elicit envelope enzyme expressing expression Factor Gene Gene Expression homeostasis Host host gene expression identify immunoregulation in vivo increase in Infected Infection Inflammation involved lack mechanisms mutant pathway Pathways potential mechanism proinflammatory Proinflammatory cytokine PROTECT Protein reduced reduction reduction in regulated respiratory respiratory syncytial virus response reversed SARS-CoV SARS-CoV E severe Signal transduction signaling pathway Stress subset Transcription transcription factor treated Treatment unfolded protein response upregulated virus virus production was reduced
[DOI] 10.1371/journal.ppat.1002315 PMC 바로가기 [Article Type] Research Article

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

Research Article

Published on 2011-05-262022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus,

[키워드] 2003 activating Activation antiviral drug assay association atomic resolution Author bind binding binding pocket CAP chromatin complex coronavirus crystal crystal structures disease enzyme etiological agent exhibit functional Genome Giant host cell identify inhibitor Innate immunity involved mechanism metabolism methyltransferase mRNA mutant non-structural protein Novel coronavirus nucleic acid performed Protein provide regulated Regulation replicate residue respiratory resulting RNA S-adenosylmethionine SAM severe Signal transduction stability Structure translation viruses
[DOI] 10.1371/journal.ppat.1002059 PMC 바로가기 [Article Type] Research Article

CXCR2 Signaling Protects Oligodendrocytes and Restricts Demyelination in a Mouse Model of Viral-Induced Demyelination

Research Article

Published on 2010-06-282022-10-28
Journal: PLoS ONE
[Category] Coronavirus,

[키워드] activating affected Apoptosis apoptotic cell BCL-2 binding caspase 3 Cell chemokine chronic infection cleavage cleaved clinical recovery CNS Culture CXCL1 CXCL2 CXCR2 decrease Demyelination disease elevated expression finding functional highlight increase in independent Infected Infection Inflammatory initiated inoculation Ligand Lineage mice Model modulation mouse mouse hepatitis virus Multiple Neuroinflammation neutralization neutralizing antiserum Oligodendrocyte pathology receptor sclerosis severity Signaling significantly susceptible sustained transcript viral infection
[DOI] 10.1371/journal.pone.0011340 PMC 바로가기 [Article Type] Research Article