Comparison of Immune Response between SARS, MERS, and COVID-19 Infection, Perspective on Vaccine Design and DevelopmentReview Article Published on 2021-01-222022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, [키워드] Adaptive immune response caused Combination coronavirus COVID-19 develop development disease drug effective epidemiological help immune response immune stimulation immune system Infection infections MERS Middle East reported researcher respiratory response responses the Coronaviridae the vaccine Vaccine virus [DOI] 10.1155/2021/8870425 PMC 바로가기 [Article Type] Review Article
Comparison of Immune Response between SARS, MERS, and COVID-19 Infection, Perspective on Vaccine Design and DevelopmentReview Article Published on 2021-01-222022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] Adaptive immune response caused Combination coronavirus COVID-19 develop development disease drug effective epidemiological help immune response immune stimulation immune system Infection infections MERS Middle East reported researcher respiratory response responses the Coronaviridae the vaccine Vaccine virus [DOI] 10.1155/2021/8870425 PMC 바로가기 [Article Type] Review Article
In silico dynamics of COVID-19 phenotypes for optimizing clinical management임상 관리 최적화를 위한 COVID-19 표현형의 인 실리코 역학Biological Sciences Published on 2021-01-192022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] 유전자 메커니즘, [키워드] ACE2 activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response adaptive immune responses age Antiviral baseline best CD8 cellular entry Clinical data clinical heterogeneity Clinical management Clinical outcome clinical outcomes Coagulation coagulation cascade Combination Comorbidities Comorbidity coronavirus COVID-19 COVID-19 patients COVID-19 phenotype COVID-19 progression Cytokines diabetes Disease progression distinctive feature dysregulated immune response element elements Evolution extreme Factors framework Health status healthy heterogeneity hypertension identify immune immune cells immune responses Infection Inflammatory cytokines innate immune response life life threatening management mathematical mathematical model mechanism Model modulating obesity Older Older age outcome oxygen oxygen saturation Patient pharmaceutical intervention predict presence of comorbidities protocols provide Renin response rate reveal risk factor SARS-CoV-2 SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus Significance Simulation sustained symptomatic T cell T cells the disease the patient therapeutic Therapies thrombosis Thrombus thrombus formation Trajectories Treatment Treatment response understanding Viral viral dynamics Viral load viral replication virus were used [DOI] 10.1073/pnas.2021642118 PMC 바로가기 [Article Type] Biological Sciences
Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?Physiology Published on 2021-01-122022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] acute respiratory syndrome Adaptive immune response Affect aging cause Cell change changes in Clinical outcome Comorbidities condition contribute coronavirus COVID-19 death determine disease Disease progression Diseases effective response feature help Host immune response illness Immune cell immune dysfunction immune response immune system Immunity immunosenescence Infection infections Infectious disease Inflamm-aging inflammatory phenotype influence lymphoid management Novel coronavirus pandemic pathophysiology peripheral tissues Quantitative respiratory infection response SARS-CoV senescent susceptibility Vaccine Vaccines [DOI] 10.3389/fphys.2020.571416 PMC 바로가기 [Article Type] Physiology
Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complicationsCOVID-19 임상 합병증을 표적으로 하는 SARS-CoV-2 수명 주기, 병태생리학 및 합리화된 치료에 대한 통찰력Review Published on 2021-01-122022-08-13 Journal: Journal of Biomedical Science [Category] Biochemistry, COVID-19, MERS, [키워드] “cytokine storm” ACE2 activate Adaptive immune response adverse effect adverse effects approach approaches ARDS AT1R clinical complication collateral tissue damage complications of COVID-19 COVID-19 CTSB Cytokine storm distress expression gastrointestinal tract Host human gene hyper-cytokinemia immune responses Infection infection rate infection rates Inflammation inflammatory immune response insight life cycle life-threatening mitigate multi-organ collapse organotropism of SARS-CoV-2 pathobiology of COVID-19 Pathologies pathophysiology Phase 1 Phase 2 Propagation respiratory respiratory and gastrointestinal tract respiratory distress Respiratory distress syndrome robust SARS-CoV-2 SARS-CoV-2 life cycle Sex Signaling Support suppress syndrome systemic failure tissue tissue damage tissues TMPRSS2 Treatment Trigger triggered triggers two-phase disease Viral viral infection virus virus antigen presentation virus transmission [DOI] 10.1186/s12929-020-00703-5 PMC 바로가기 [Article Type] Review
Immunology, immunopathogenesis and immunotherapeutics of COVID-19; an overviewReview Published on 2021-01-052022-11-01 Journal: International immunopharmacology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Adaptive immune response addition Anti-viral immunity antiviral therapy association caused component contagious Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pathogenesis diagnostic disease effective therapy Evidence health emergency high mortality rate immune immune dysregulation immune response immunology Immunopathogenesis Immunotherapy Infection infections Inflammation inhibiting International lung damage management mechanism occur pathogenic pathophysiology PHEIC prophylactic strategy pulmonary SARS-CoV-2 systemic inflammation Treatment understanding virus [DOI] 10.1016/j.intimp.2020.107364 PMC 바로가기 [Article Type] Review
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progressionResearch Article Published on 2020-12-242022-10-30 Journal: Life Science Alliance [Category] COVID-19, MERS, SARS, [키워드] adaptive Adaptive immune response B cell can be used CD4 CD8 T-cell Cell change changes in Classifier COVID-19 patient Critical death deep Disease progression disease severity healthy controls healthy donors immune Immune cell immune dysfunction immune profiling immune response implementation incidence KIR lymphocyte mild case mononuclear cell morbidity and mortality myeloid cell natural killer Patient performed Peripheral blood Population predict Profiling progression receptor reveal rising risk selected severe disease Therapies [DOI] 10.26508/lsa.202000955 PMC 바로가기 [Article Type] Research Article
mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2중증 급성 호흡기 증후군 코로나바이러스 2에 대한 적응 면역 반응 연구를 위해 쥐에서 mRNA 유도 인간 안지오텐신 전환 효소 2 발현Research Article Published on 2020-12-162022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Antigen Antiviral Author caused CD4+ CD4+ T cell CD8+ CD8+ T cell cells cloned coronavirus Critical demonstrated Efficacy entry of SARS-CoV-2 Epitopes expressed expression functional hACE2 hACE2 receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human coronavirus humans immune response in vivo induce Infection information interferon receptor Laboratory lack membrane Membrane proteins memory mice mRNA mRNA expression mRNA transfection mRNA-based murine murine model murine models nucleocapsid pandemic peptide peptide epitope peptides preserved provided receptor Replication required respiratory response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis Secondary infection severe acute respiratory syndrome Coronavirus Spike proteins strain T cell T cell epitope T cell epitopes T cell response T cells this system type 1 interferon unique Vaccine vaccine efficacy Vaccines virus [DOI] 10.1371/journal.ppat.1009163 PMC 바로가기 [Article Type] Research Article
Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases무증상, 경증 및 중증 사례의 SARS-CoV-2 감염에 대한 다양한 선천성 및 적응성 면역 반응Clinical Trial Published on 2020-12-162022-08-13 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, [키워드] adaptive Adaptive immune response antibodies Antibody Response Asymptomatic asymptomatic individual Asymptomatic individuals B cells Clinical course clinical expression Clinical presentations Course COVID-19 COVID-19 cases COVID-19 disease eight excessive inflammation Follow-up Frequency healthy humans IgA IgG IgM immune responses Immunity Immunological studies Immunological study individual immune response infected cases Infection Innate innate and adaptive immunity innate and adaptiveimmune response kinetics of antibody memory Mild Mild COVID-19 disease Mild disease moderate to severe monocyte Monocytes NK cell NK cells Novel coronavirus organ damage Patient patients with moderate performed produced Protective protective immune response response SARS-CoV-2 SARS-CoV-2 illness SARS-COV-2 infection SARS-CoV-2-negative contact serological analysis severe COVID-19 severe COVID-19 disease severe disease short-lived Spectrum tissue tissues with mild disease [DOI] 10.3389/fimmu.2020.610300 PMC 바로가기 [Article Type] Clinical Trial
IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 PatientsSARS-CoV-2에 대한 IgA2 항체는 중증 COVID-19 환자의 NET 형성 및 치명적인 결과와 상관 관계가 있습니다Communication Published on 2020-12-122022-09-11 Journal: Cells [Category] MERS, SARS, 바이오마커, 진단, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus Adaptive immune response anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody antibody level antibody levels C-reactive protein C-reactive protein (CRP characterized circulating contribute Control coronavirus correlated COVID-19 CRP level CRP levels extracellular DNA Formation Hospitalization Host ICU IgA IgA2 IgG response IgG responses Immune cell immune cells induce Infection Inflammation intensive care intensive care unit leads less marker mild symptoms moderate moderate symptoms NET neutrophil Neutrophil extracellular trap neutrophil extracellular trap (NET) organ injury outcome Patient patient groups patients plasma sample plasma samples respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2-infected patient SARS-CoV-2-infected patients SARS-CoV-2-specific IgG severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease severe SARS severe SARS-CoV-2 specific antibodies Spike protein Symptom the strongest These data TRAP were measured while [DOI] 10.3390/cells9122676 PMC 바로가기 [Article Type] Communication