A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses고도로 병원성 코로나 바이러스를 포함하여 포집 바이러스에 대한 광범위한 항 바이러스 활성을 갖는 광 활성화 가능한 천연 제품Antiviral Agents Published on 2021-11-222022-09-10 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] active against activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity Antiviral agents broad-spectrum antiviral broad-spectrum antivirals bronchial epithelial cells Cell fusion coronavirus CoV replication CoV-229E COVID-19 COVID-19 therapy CoVs Cryoelectron microscopy demonstrated described Disinfection epithelial cells highly active human CoV Including inhibit inhibitor mechanism of action MERS MERS-CoV Microscopy Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus natural natural antiviral natural product outbreak primary human bronchial epithelial cells product reduced Replication respiratory respiratory syndrome coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown therapy Viral viral membrane viral particle virucidal virus virus entry viruses [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic CoronavirusesAntiviral Agents Published on 2021-11-222022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] active against activity acute respiratory syndrome Antiviral antiviral activity Antiviral agents broad-spectrum antiviral bronchial epithelial cells coronavirus CoV-229E COVID-19 CoVs demonstrated described highly active Including inhibit inhibitor mechanism of action MERS-CoV Microscopy Middle East natural natural antiviral natural product outbreak product reduced Replication respiratory syndrome coronavirus SARS-CoV-2 shown therapy viral membrane viral particle virucidal virus virus entry [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic CoronavirusesAntiviral Agents Published on 2021-11-222022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] active against activity acute respiratory syndrome Antiviral antiviral activity Antiviral agents broad-spectrum antiviral bronchial epithelial cells coronavirus CoV-229E COVID-19 CoVs demonstrated described highly active Including inhibit inhibitor mechanism of action MERS-CoV Microscopy Middle East natural natural antiviral natural product outbreak product reduced Replication respiratory syndrome coronavirus SARS-CoV-2 shown therapy viral membrane viral particle virucidal virus virus entry [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
Mobile computed tomography for the efficient allocation of medical resources in patients with COVID-19 pneumonia A case report코로나19 폐렴 환자의 효율적인 의료자원 배분을 위한 이동형 컴퓨터단층촬영 증례보고Case Reports Published on 2021-11-192022-09-10 Journal: Medicine [Category] MERS, SARS, 진단, 치료제, [키워드] allocation of resources Antibiotics Antiviral agents Burnout Care Case report Chest computed tomography Chest CT chest CT scan chest X-ray clinical condition clinician Computed tomography cone-beam computed tomography conservative treatment consolidation contagious coronavirus Coronavirus 2019 cough COVID-19 COVID-19 patients COVID-19 pneumonia CT scan CT scanning Dyspnea events Exhaustion Fever Ground-glass opacities ground-glass opacity Healthcare systems Infection Isolation medical resource Medical resources medical staff Mobile Mobile application Nurse Patient patient with COVID-19 patients patients with COVID-19 performed Pneumonia presenting problem problems Propagation radiologist raise required resource Safe scanning subpleural syndrome Treatment Treatment response [DOI] 10.1097/MD.0000000000027872 PMC 바로가기 [Article Type] Case Reports
Identification of Cellular Factors Required for SARS-CoV-2 ReplicationArticle Published on 2021-11-132022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 Antiviral agents Asymptomatic disease cellular factors clinical complex coronavirus COVID-19 pandemic CRISPR-Cas9 cross death entry receptor Factor HeLa cell host cell host–virus interaction Human identification include infect Infection insight Interaction knock-out Lung injury mechanisms of infection mild respiratory multifactorial multiorgan failure Organisms overexpressing platform Prevent receptors replicate replication mechanism required responsible resulting SARS-CoV-2 SARS-COV-2 infection severe disease unique viral pathogenesis viral replication virus [DOI] 10.3390/cells10113159 PMC 바로가기 [Article Type] Article
COVID-19 Advanced CareReview Published on 2021-10-252022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] 28-day mortality acute respiratory syndrome Antibiotics Anticoagulant anticoagulation Antiviral agents antiviral therapies Care caused complications coronavirus coronavirus disease COVID-19 Dexamethasone Disease progression Efficacy Evidence Hospitalization hyperimmune hypoxic respiratory failure immune include increase in individuals with COVID-19 management monoclonal antibodies monoclonal antibody multiorgan disease ongoing trial outcome pandemic passive immune therapies Patient Pneumonia public health reduce requiring supplemental oxygen Research SARS-CoV-2 Severe acute respiratory syndrome systemic corticosteroids therapy usual care [DOI] 10.3390/jpm11111082 PMC 바로가기 [Article Type] Review
Molnupiravir—A Novel Oral Anti-SARS-CoV-2 AgentPerspective Published on 2021-10-232022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] acute respiratory syndrome agent antiviral agent Antiviral agents benefit clinical trial coronavirus COVID-19 COVID-19 patient death deaths demonstrated Efficacy EIDD-1931 EIDD-2801 eliminating Enrollment evidenced expected global pandemic Hospitalization inhibitor Mild Moderate COVID-19 molnupiravir nasopharyngeal novel oral Patient Prevent progression Prophylactic public health reduced released risk RNA polymerase inhibitor RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 transmission significantly therapeutic doses therapy treat Trial trials virus [DOI] 10.3390/antibiotics10111294 PMC 바로가기 [Article Type] Perspective
Association between chronic hepatitis B infection and COVID-19 outcomes: A Korean nationwide cohort study만성 B 형 간염 감염과 COVID-19 결과의 연관성 : 한국 전국 코호트 연구Research Article Published on 2021-10-052022-09-10 Journal: PLoS ONE [Category] B형 간염, MERS, 치료제, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted odds ratio Antiviral antiviral agent Antiviral agents Antiviral treatment association CHB chronic hepatitis Chronic Hepatitis B Clinical outcome cohort study Coinfection collected Comorbidities Comorbidity Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 negative COVID-19 positive patient database disease severity Endpoint entecavir greater HBV Health Insurance Infection infection rate infection rates insurance Korean lead National Health Insurance negative controls Patient positive positive patients primary endpoints proportion random reduced respiratory Result risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity SARS-CoV-2 test selected service severe acute respiratory syndrome Coronavirus statistically susceptibility target population tenofovir test result tested Treatment with infection worse prognosis [DOI] 10.1371/journal.pone.0258229 PMC 바로가기 [Article Type] Research Article
Retrospective SARS-CoV-2 IgG screening during the first wave (March-June 2020) of the COVID-19 pandemic in the United Kingdom영국에서 COVID-19 범유행의 첫 번째 물결(2020년 3월-6월) 동안 소급 SARS-CoV-2 IgG 스크리닝Article Published on 2021-10-012022-09-12 Journal: Journal of medical virology [Category] Fulltext, MERS, 진단, [키워드] acute respiratory syndrome Antiviral Antiviral agents asymptomatic individual collected Community coronavirus coronavirus disease COVID-19 COVID-19 pandemic feasible First wave IgG immune immune globulin Immunoglobulin incidence initial local laboratories lockdown lowest Measures NHS offer pandemic Pandemics peaking polymerase chain positive resulting retrospective SARS Coronavirus SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 transmission sera tested Transmission transmission of SARS-CoV-2 Trust United Kingdom university virus virus classification was performed [DOI] 10.1002/jmv.27162 PMC 바로가기 [Article Type] Article
Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studiesResearch article Published on 2021-10-012022-10-05 Journal: European journal of medicinal chemistry [Category] SARS, 치료제, [키워드] Antiviral agents antiviral drug binding binding pocket biochemical cellular cleave colloid complexes concentrations coronavirus counter ion COVID-19 Crystallography demonstrated derivative effective inhibitor Efficacy form GC376 analogs group Improved increase increased solubility inhibitor main protease media MPro nanomolar affinity NMR physical polar protease Protease inhibitor replacement reported SARS-CoV-2 SARS-CoV-2 Mpro Structure Structure-guided design therapeutic Viral proteins [DOI] 10.1016/j.ejmech.2021.113584 [Article Type] Research article