SARS-CoV-2 Infection Induces a Dual Response in Liver Function Tests: Association with Mortality during HospitalizationArticle Published on 2020-09-042022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] abnormality acute respiratory syndrome adjusted Admission age and sex alanine aminotransferase albumin levels alkaline phosphatase ALP ALT Aspartate aminotransferase associations AST Biochemistry change conducted coronavirus COVID-19 defined determine died discharged elevated evaluated ferritin Follow-up follow-up period function hepatic biomarkers Hospitalization hospitalized patients increase intensive care Laboratory limit liver Liver damage liver function tests mixed models normality Patient prevalent reduced respiratory complication response Retrospective study SARS-CoV-2 single-center subsequent Surveillance survival trajectory [DOI] 10.3390/biomedicines8090328 PMC 바로가기 [Article Type] Article
May we target double-membrane vesicles and oxysterol-binding protein to combat SARS-CoV-2 infection?Review Published on 2020-09-012023-08-30 Journal: Cell biology international [Category] E형 간염, [키워드] Biochemistry Pharmacology viruses [DOI] 10.1002/cbin.11400 PMC 바로가기 [Article Type] Review
Commentary: Challenges for PhD students during COVID-19 pandemic: Turning crisis into an opportunity논평: COVID-19 전염병 동안 박사 과정 학생의 도전: 위기를 기회로Article Published on 2020-09-012022-09-11 Journal: Biochemistry and Molecular Biology Education [Category] SARS, 유전자 메커니즘, [키워드] activity Biochemistry challenge contrary Course COVID-19 COVID-19 crisis except for experiment extreme IMPROVE knowledge life Molecular biology PhD education Suspension turn Turning universities university [DOI] 10.1002/bmb.21351 PMC 바로가기 [Article Type] Article
An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitorsArticle Published on 2020-08-172022-10-04 Journal: Scientific Reports [Category] MERS, 신약개발, 치료제, [키워드] ACE2 approved Biochemistry caused Clinical studies Computational biology and bioinformatics Coronavirus disease 2019 COVID-19 de novo docking drug Drug discovery effective FDA approved drug glycoprotein high affinity host cell host cell membrane humans identify in silico Infectious disease inhibitor initiate Interaction lumacaftor molecular overcome pandemic Prevent Protein recent receptor ACE2 reduce robust SARS-CoV SARS-CoV-2 SARS-CoV-2 viral shown significantly Simeprevir SMD spike Spread structural biology the receptor-binding domain the Spike Vaccine viral entry Virtual screening virus [DOI] 10.1038/s41598-020-70863-9 PMC 바로가기 [Article Type] Article
A Specialized Clinical Laboratory Center for the Coronavirus Disease 2019 (COVID-19) in Wuhan Leishenshan Hospital During the COVID-19 OutbreakReport from the Field Published on 2020-08-122022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antibody average Biochemistry center clinical clinics Complete coronavirus coronavirus disease country COVID-19 Emergency extreme Fever Health care worker hospital Immunity Infection Inpatient Laboratory Measures medical resource nucleic acid test outbreak Patient per day provided resource Responding SARS-CoV-2 Support suspected patient Test Treatment Wuhan Wuhan, China [DOI] 10.1017/dmp.2020.293 PMC 바로가기 [Article Type] Report from the Field
Potentially modifiable factors to reduce severity of COVID-19 in type 2 diabetesEditorial Published on 2020-08-122022-10-29 Journal: Nutrition & Diabetes [Category] COVID-19, MERS, [키워드] Biochemistry Cell Biology Factor reduce severity of COVID-19 type 2 diabete [DOI] 10.1038/s41387-020-00133-0 PMC 바로가기 [Article Type] Editorial
Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepaticaArticle Published on 2020-08-102023-05-31 Journal: Scientific Reports [Category] Fulltext, 조류인플루엔자, [키워드] Biochemistry Biological techniques Cell Biology Diseases Medical research Molecular biology Pathogenesis Zoology [DOI] 10.1038/s41598-020-69970-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing studyResearch article Published on 2020-07-232022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] acute respiratory syndrome amino acid residue anti-viral drug approach approved binding pocket Biochemistry bioinformatics Biological sciences candidate China cisatracurium cofactor complex coronavirus COVID-19 database Dependent drug Drug repurposing effective Examorelin FDA FDA approved drug form Health include Interaction Lypressin Molecular biology molecular docking simulation Ornipressin outbreak pandemic Pharmaceutical science polymerase Polymyxin B1 RdRP RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA screened sustained therapeutic options Vaccine X-ray crystallography [DOI] 10.1016/j.heliyon.2020.e04502 [Article Type] Research article
CD4 + T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical FeaturesArticle Published on 2020-07-142023-05-31 Journal: Cell Reports [Category] Fulltext, 조류인플루엔자, [키워드] Biochemistry CD4 T cells clonotyping HLA class II immunology Influenza peptide epitopes pHLA mutlimer T cell receptor X-ray crystallography [DOI] 10.1016/j.celrep.2020.107885 PMC 바로가기 [Article Type] Article
A candidate multi-epitope vaccine against SARS-CoV-2Article Published on 2020-07-022022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Analysis antigenic Biochemistry candidate vaccine caused codon optimization Computational biology and bioinformatics coronavirus determinants docking study Dynamics E. coli effective Efficiency expression Fatality rate host cell immune response Immune simulation immunology in silico In silico cloning induce Interaction MERS-CoV MHC Multi-epitope vaccine outbreak pandemic SARS-CoV SARS-CoV-2 Simulation spike glycoprotein stability supported the vaccine Vaccine vaccine candidate virus [DOI] 10.1038/s41598-020-67749-1 PMC 바로가기 [Article Type] Article