Decreased severity of COVID-19 in vaccinated pregnant individuals during predominance of different SARS-CoV-2 variants다양한 SARS-CoV-2 변이가 우세한 동안 예방 접종을 받은 임산부의 COVID-19 중증도 감소Article Published on 2022-09-012022-09-11 Journal: American journal of reproductive immunology (New Y [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Analysis Breakthrough infection Cohort Comorbidities coronavirus COVID-19 Critical Critical disease Decreased delta variant determine develop Diagnosis disease severity effective Effectiveness hospital ICU admissions individual less monoclonal antibodies obesity pandemic Patient positive Pregnancy pregnant Primary outcome progressed progression Protective receipt reducing retrospective cohort study SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe disease severity of COVID-19 shown tested the patient trimester two group two groups vaccinated individual vaccinated individuals vaccination Vaccination Status Vaccine variants of SARS-CoV-2 was performed [DOI] 10.1111/aji.13596 PMC 바로가기 [Article Type] Article
Anti-spike IgG antibody kinetics following the second and third doses of BNT162b2 vaccine in nursing home residentsArticle Published on 2022-09-012022-11-15 Journal: Journal of the American Geriatrics Society [Category] COVID19(2023년), SARS, 진단, [키워드] assumed BNT162b2 carried Cohort cohorts correlated COVID-19 Critical different time point dose Duration form group IgG antibody induce magnitude median age mRNA BNT162b2 vaccine nursing homes of BNT162b2 provide quantification R 2 robust SARS-CoV-2 SARS-COV-2 infection Seven subgroup of patients subject subjects vaccination Vaccine [DOI] 10.1111/jgs.17837 PMC 바로가기
Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular DiseaseArticle Published on 2022-09-012022-11-16 Journal: Cells [Category] 유전자 메커니즘, [키워드] alleviate antioxidants Arrhythmias Atherosclerosis Cardiomyopathy cardiovascular cardiovascular disease Cell cell death characterized conditions Critical CVD cytoplasmic Defense demonstrated detoxify DHODH enzyme activity Evidence expected Fenton reaction Ferroptosis genetic manipulation heart failure implication induce inhibitors Injury involved iron lipid peroxidation LOX membrane Mitochondria mitochondrial mitochondrial membrane molecular mechanism Pathogenesis Pathways peroxidase Protein regulated Relevance ROS therapeutic option [DOI] 10.3390/cells11172726 PMC 바로가기
Biobanking in times of crisis – The COVID-19 Autopsy and Biosample Registry Baden-WuerttembergResearch article Published on 2022-09-012022-10-05 Journal: Pathology, research and practice [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Research and Arts acute respiratory syndrome Autopsy Baden-Wuerttemberg BBMRI-ERICBiobanking and Biomolecular Resources Research Infrastructure – European Research Infrastructure Consortium biobanking Biobanking and Biomolecular Resources Research Infrastructure – European Research Infrastructure Consortium Biomarker biospecimens BWBaden-Wuerttemberg caused Central Biosample Register coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 disease COVID-19coronavirus disease 2019 Critical Deceased DeRegCOVIDNational COVID-19 Registry diagnostic diagnostics Diseases DZIFGerman Center for Infection Research DZLGerman Center for Lung Research effort FFPEformalin-fixed FIVE formalin-fixed GBAGerman Biobank Alliance GBNGerman Biobank Node German Biobank Alliance German Biobank Node German Center for Infection Research German Center for Lung Research Germany Heidelberg University Hospital management Ministry of Science MWKMinistry of Science National COVID-19 Registry Network of University Medicine NUMNetwork of University Medicine paraffin-embedded Patient Paul-Ehrlich-Institut PEIPaul-Ehrlich-Institut public health registry Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2severe acute respiratory syndrome coronavirus-2 severe acute respiratory syndrome coronavirus-2 SOPStandard operating procedure Standard operating procedure Support supported tissue tissue sample treatment approach Tübingen UKHDHeidelberg University Hospital Ulm university hospital vaccination WHOWorld Health Organization World Health Organization ZBRCentral Biosample Register [DOI] 10.1016/j.prp.2022.154011 [Article Type] Research article
Network analysis for elucidating the mechanisms of Shenfu injection in preventing and treating COVID-19 combined with heart failureResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acting acute respiratory syndrome Analysis approach biological process biological processe caused cell differentiation China Chinese components Compound compound screening coronavirus COVID-19 COVID-19 case Critical cytokine signaling Cytoscape Cytoscape software Diagnosis drug-likeness Effectiveness enrichment analysis Evidence heart failure Hemostasis identify IL-17 immune system indicated Infection Inflammatory response injection involved KEGG pathway Kyoto Lung injury mechanism Medicine National Health Commission network network analysis novel coronavirus disease objective overlapped Pathway analysis Pathway enrichment analysis Pathways patients with COVID-19 pharmacological mechanism Pharmacological mechanisms Pharmacology progression protein-protein interaction regulated Respiratory failure Result SARS-CoV-2 Shenfu injection signaling pathway Stage suggested syndrome System target targets TCM Th17 therapeutic therapy Traditional treat treating COVID-19 Treatment was used [DOI] 10.1016/j.compbiomed.2022.105845 [Article Type] Research article
Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesisReview article Published on 2022-09-012022-10-05 Journal: Cell Calcium [Category] SARS, 신약개발, 임상, 치료제, [키워드] acting calcium Calcium signaling Clinical management clinical trial clinical trials coronavirus disease COVID-19 COVID-19 pathogenesis Critical curtail driving drug regimen Efficacy handling homeostasis host cell Host cell calcium dynamics identify impacted Infection interact management mechanisms molecular molecular mechanism pathway Potential Protein reducing Replication reported respiratory SARS-CoV-2 SARS-COV-2 infection severity Signaling signaling cascade small molecule the disease Transport vaccination [DOI] 10.1016/j.ceca.2022.102637 [Article Type] Review article
Second round of an interlaboratory comparison of SARS-CoV2 molecular detection assays used by 45 veterinary diagnostic laboratories in the United StatesArticle Published on 2022-09-012022-11-15 Journal: Journal of veterinary diagnostic investigation : o [Category] SARS, 변종, 치료기술, [키워드] addition analyst analytical sensitivity Analytical specificity analyzed assays B.1.1.7 B.1.351 buffer COVID-19 COVID-19 pandemic Critical detect diagnosis of COVID-19 diagnostic evaluate evaluated FDA help humans identify interlaboratory comparison investigation Laboratory limitations marker medium molecular N1 and N2 network nucleocapsid pandemic public health real-time RT-PCR recognize response RNA RT-rtPCR SARS-CoV2 second specificity Support the United State Transport variant variants Viral RNA [DOI] 10.1177/10406387221115702 PMC 바로가기
Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortalityResearch article Published on 2022-09-012022-10-05 Journal: Cytokine [Category] COVID19(2023년), SARS, 변종, [키워드] 25-hydroxyvitamin D acute respiratory syndrome adaptive amplification Analysis coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 mortality creatinine Critical cytoplasm dead dead patient erythrocyte sedimentation rate ESR evaluate Factors Genetic Genotype genotyped Host IFITM3 Impact increased mortality indicated innate immune response Interferon-induced transmembrane protein 3 liver enzymes membrane minor allele frequency Mortality multivariate logistic regression Mutation parameters Patient PCR polymorphism positive profiles required Result SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 significantly more suggested transmembrane protein uric acid viral cell [DOI] 10.1016/j.cyto.2022.155957 [Article Type] Research article
SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerationsReview article Published on 2022-09-012022-10-05 Journal: Ageing research reviews [Category] COVID19(2023년), SARS, 비임상, [키워드] ACE2 angiotensin-converting enzyme 2 association Blood Brain brain fog cause caused cells cellular senescence comorbid conditions consequence Consequences coronavirus coronavirus 2 Coronavirus disease 2019 COVID COVID-19 Critical death Degradation Diseases event Ferroptosis Genome Genome instability hemorrhage hemorrhagic damage Increases individual lesion likelihood multi-organ failure neurodegenerative neurological Neurological complications Neurovascular occur organ pathology predisposition prognostic raise respiratory SARS-CoV-2 SARS-COV-2 infection senescence shown Strains Survivors systemic inflammation target therapeutic Therapeutic strategies widespread [DOI] 10.1016/j.arr.2022.101687 [Article Type] Review article
Biomarkers selection for population normalization in SARS-CoV-2 wastewater-based epidemiologyArticle Published on 2022-09-012022-11-15 Journal: Water research [Category] SARS, 바이오마커, [키워드] 5-hydroxyindoleacetic acid acute respiratory syndrome addition approach Biomarker Biomarkers CDC changes in city Community complement Concentration contributing to coronavirus coronavirus disease correlation COVID-19 creatinine Critical demonstrated Dilution distribution epidemiological Epidemiology evaluated FIVE help high accuracy investigated Local metabolite Mild normalized outbreak Paraxanthine plant Population Population biomarker Population normalization Prevalence reported SARS-CoV-2 SARS-CoV2 selected significantly tested the SARS-CoV-2 Treatment utility Variability Viral load viral loads virus Volume Wastewater-based epidemiology [DOI] 10.1016/j.watres.2022.118985 PMC 바로가기