In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV-2 genomic data선택된 동물성 코로나바이러스에서 S-유전자 영역의 인-실리코 뉴클레오티드 및 단백질 분석은 SARS-CoV-2 게놈 데이터에서 바이러스 진입의 궤적 과정과 함께 보존된 도메인 및 진화적 출현을 나타냅니다Research Published on 2020-11-302022-09-10 Journal: The Pan African Medical Journal [Category] Fulltext, MERS, SARS, 유전자 메커니즘, 조류인플루엔자, [키워드] 229E Affect Analysis analyzed ancestors antagonistic action Antiviral cellular mechanism clades conserved conserved domains coronavirus Course COVID-19 dating domain domains effective Evolution FIVE genomic genomic data Host host cells human coronavirus human population human populations include management Migration Multiple sequence alignment multiple sequence alignments Mutation nucleotide outbreak Outbreaks pandemic pathway Phylogeny Population Profiling Protein Racial respiratory Respiratory Coronavirus Result S gene S-gene SARS-CoV-2 SARS-CoV-2 genomic data SARS-CoV-2 phylogeny selected sequence alignments severe acute respiratory coronavirus spike gene target the SARS-CoV-2 therapeutic trajectory Viral viral entry virus viruses Wuhan zoonotic Zoonotic coronavirus zoonotic coronaviruses zoonotic CoVs [DOI] 10.11604/pamj.2020.37.285.24663 PMC 바로가기 [Article Type] Research
Differential impact of BTK active site inhibitors on the conformational state of full-length BTKResearch Article Published on 2020-11-232022-10-31 Journal: eLife [Category] Coronavirus, SARS, [키워드] activated Affect allergy Allostery antibodies approved Asthma B cell B-cell B-cells bind binding Blood bruton tyrosine kinase BTK BTK inhibitor BTK inhibitors Cancer Cancer cells cancers catalytic activity change Chemotherapy conformational consequence COVID-19 Diseases disorder disrupt disrupting domain domains drug drug resistance drugs Effect effective enzyme examined FIVE full-length full-length protein Future help hydrogen/deuterium exchange mass spectrometry Ibrutinib inactive increase inhibitor inhibitors Interaction Joseph Kinase inhibitor leukemia lymphoma lymphomas maintain mechanism modify Mutation None not affect nuclear magnetic resonance other compound other disease phosphate Previous effort Protein Proteins Region regions Regulatory regulatory domain regulatory region Research responsible shifting treat treated treating COVID-19 Treatment treatment strategy tyrosine understanding while White blood cell [DOI] 10.7554/eLife.60470 PMC 바로가기 [Article Type] Research Article
Evaluation on the use of Nanopore sequencing for direct characterization of coronaviruses from respiratory specimens, and a study on emerging missense mutations in partial RdRP gene of SARS-CoV-2호흡기 표본에서 코로나바이러스의 직접적 특성 규명을 위한 나노포어 염기서열 분석의 사용에 대한 평가 및 SARS-CoV-2의 부분 RdRP 유전자에서 출현하는 미스센스 돌연변이에 대한 연구Short Report Published on 2020-11-232022-09-10 Journal: Virology Journal [Category] SARS, 변종, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Amplicon amplicons amplified antiviral drug antiviral drugs catastrophic collected component Consensus conserved coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 outbreak database Decision making diagnostic domains Efficacy etiologic agent Europe evaluated feasibility Flongle Frequency genetic marker Genome GISAID global healthcare high mutation rate highest highlight Hong Kong human coronaviruses identify knowledge MinION Missense mutation Missense mutations mutation rate mutations Nanopore nanopore sequencing nucleotide pandemic Partial platform positive provided public health RdRP RdRp gene RdRp sequences respiratory respiratory specimens RNA polymerase RNA viruses SARS-CoV-2 sequence sequenced Sequencing severe acute respiratory syndrome Coronavirus Single nucleotide variant SNV SNVs specimen specimens Spread Surveillance Vaccines variant virus [DOI] 10.1186/s12985-020-01454-3 PMC 바로가기 [Article Type] Short Report
Mental Health Status of Psychogeriatric Patients During the 2019 New Coronavirus Disease (COVID-19) Pandemic and Effects on Caregiver BurdenPsychiatry Published on 2020-11-172022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] Administered ANOVA test Anxiety apathy association Brazil burden Caregiver caregiver burden caregiver distress clinical clinically Coronavirus disease 2019 (COVID-19) correlated Correlation analysis COVID-19 COVID-19 pandemic Dementia Depression determine disorder distress domains Down syndrome Effect emotional HADS hospital in both groups independent indicated information inventory linear magnitude medical records mental health Neuropsychiatric New noxious Older pandemic Participants Patient patients positive predict Psychiatric psychogeriatrics questionnaire R 2 Research scale significantly sleep disorders status subjects Symptom Symptoms the patient total score was obtained were used worsening [DOI] 10.3389/fpsyt.2020.578672 PMC 바로가기 [Article Type] Psychiatry
Psychological Distress of University Workers during COVID-19 Pandemic in BrazilArticle Published on 2020-11-172022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] 95% confidence interval age analyzed Brazil category clinical complex components COVID-19 Cross-sectional studies demographics distress domains Effect female Health help indicated Isolation medium Mental pandemic Pandemics participant participated physical predictor professionals Psychiatric Psychological distress Qualitative qualitative data Quantitative quarantine question reduced response routine social distancing social environment Support Treatment university worker [DOI] 10.3390/ijerph17228520 PMC 바로가기 [Article Type] Article
EAES Recommendations for Recovery Plan in Minimally Invasive Surgery Amid COVID-19 PandemicEAES Recommendations Published on 2020-11-102022-10-28 Journal: Surgical endoscopy [Category] COVID-19, SARS, [키워드] abdominal wall activity addressed approved clinical setting clinician Community Consensus COVID-19 COVID-19 crisis COVID-19 pandemic defined DelPhi Delphi consensus domains EAES guidance eight Endocrine Evidence Healthcare systems minimally invasive surgery MIS Modification plan priority question recommendation representing Research Result resulting Safe supplementary material surgery surgical was performed [DOI] 10.1007/s00464-020-08131-0 PMC 바로가기 [Article Type] EAES Recommendations
A Multimodal Real-Time Feedback Platform Based on Spoken Interactions for Remote Active Learning SupportArticle Published on 2020-11-062022-10-29 Journal: Sensors (Basel, Switzerland) [Category] Coronavirus, SARS, [키워드] analytics collocated collaboration analytics COVID-19 pandemic distribution domains Efficiency facilitate feedback groups homogeneous identify IMPROVE Interaction Intervention learning MONITOR multimodal learning analytics platform provide Quantitative real-time feedback remote social network analysis Stage subject supported verbal while [DOI] 10.3390/s20216337 PMC 바로가기 [Article Type] Article
Health-Related Quality of Life and Influencing Factors of Pediatric Medical Staff During the COVID-19 OutbreakPublic Health Published on 2020-10-222022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] can be used Care clinician clinics cognitive conducted COVID-19 COVID-19 epidemic COVID-19 outbreak cross-sectional develop domain domains emotional evaluate Evidence Factor Factors Fever Health Health related quality of life IMPROVE Intervention intervention measures life male measure medical staff mental health multivariable logistic regression Nurse observation Pandemics participant pediatric pediatrics medical staff physical professional Quality Quality of life recruited respondent scored treated patient were used with COVID-19 [DOI] 10.3389/fpubh.2020.565849 PMC 바로가기 [Article Type] Public Health
Framework for a Community Health Observing System for the Gulf of Mexico Region: Preparing for Future DisastersPublic Health Published on 2020-10-152022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] acquisition Allostatic load assessments baseline Biomarker Cohort Cohort studies collected Community consequence COVID-19 COVID-19 pandemic cumulative data management develop Developing disaster Disasters domains Effect effective Electronic health records environmental exposure facilitate FIVE framework Future groups Gulf of Mexico Health health information health monitoring health observation health observing system Health surveillance identify include Inclusion Infectious disease information knowledge lack measure media Mental mitigate National Observing Pandemics participant physical Population Preparing Questionnaires recruitment Region secondary Significant specimen specimens statistically stratified Stress Surveillance sustained System unique [DOI] 10.3389/fpubh.2020.578463 PMC 바로가기 [Article Type] Public Health
Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 InfectionPharmacology Published on 2020-10-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activated antiviral activity arginine residue arginine residues bioinformatics caused cellular Concentration conserved coronavirus COVID-19 COVID-19 disease cysteine residue domain domains Doxorubicin drug effective vaccine Efficacy Evidence examined expected functional global pandemic glyoxalase inactivation Infection interactions MERS metabolite methylglyoxal Modification oxidative paclitaxel physiological system predicted produced producing proteome proteomics Quantitative reactive reactive oxygen specy residue ROS SARS-CoV SARS-CoV-2 selective susceptible targets the SARS-CoV-2 the spike protein therapeutic therapy Toxicity Treatment virucidal vulnerability [DOI] 10.3389/fphar.2020.585408 PMC 바로가기 [Article Type] Pharmacology