Three waves changes, new variant strains, and vaccination effect against COVID-19 pandemicCOVID-19 대유행에 대한 3가지 물결 변화, 새로운 변종 균주 및 백신 접종 효과Review Published on 2022-04-152022-09-11 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] appearance approved asked B.1.1.529 B.1.617.2 changes Characteristics China Corona virus coronavirus COVID-19 COVID-19 pandemic decrease delta variant dose Effect eight expected extreme Factors feature India information introduced market mortality rates mutant Mutation New New variant strain omicron producing question Reinfection reported SARS-CoV-2 sense severity Side effect Side effects South Africa Spread strain Strains Symptoms the disease the epidemic Transmissibility vaccination Vaccine Vaccines variant variants viral fitness virus virus replication [DOI] 10.1016/j.ijbiomac.2022.01.118 PMC 바로가기 [Article Type] Review
Interaction Analysis of the Spike Protein of Delta and Omicron Variants of SARS-CoV-2 with hACE2 and Eight Monoclonal Antibodies Using the Fragment Molecular Orbital Method단편 분자 궤도 방법을 사용한 hACE2 및 8개의 단일클론 항체와 SARS-CoV-2의 델타 및 오미크론 변이체의 스파이크 단백질 상호작용 분석Article Published on 2022-04-112022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin binding binding affinities binding affinity changed changes in coronavirus crystal structure Delta eight enzyme fragment hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Interaction molecular monoclonal antibodies monoclonal antibody mutated Mutation omicron Omicron variant performed predict predicted Protein Quantum mechanics required residue respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein statistical analysis the binding affinity the Spike the spike protein variant variant of SARS-CoV-2 Viral viral surface [DOI] 10.1021/acs.jcim.2c00100 PMC 바로가기 [Article Type] Article
Lessons Learned From Implementing Digital Health Tools to Address COVID-19 in LMICsLMIC에서 COVID-19를 해결하기 위한 디지털 건강 도구 구현에서 배운 교훈Article Published on 2022-04-082022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] address assessment Care content country COVID-19 COVID-19 pandemic detect Digital Digital health effort eight Factor Future Health Health care health system health systems health worker implementation Implementing IMPROVE information lesson LMICs mHealth Novel coronavirus Planning populations Primary Health Care public health Research respond robust scale SDGs solution strained Support Sustainable Development Goals user-centered design widespread [DOI] 10.3389/fpubh.2022.859941 PMC 바로가기 [Article Type] Article
Study protocol for a modified antenatal care program for pregnant women with a low risk for adverse outcomes-a stepped wedge cluster non-inferiority randomized trial부작용 위험이 낮은 임산부를 위한 수정된 산전 관리 프로그램에 대한 연구 프로토콜-단계적 쐐기형 클러스터 비열등성 무작위 시험Article Published on 2022-04-082022-09-11 Journal: BMC Pregnancy and Childbirth [Category] 임상, [키워드] adverse events adverse outcome adverse outcomes Antenatal antenatal care Care Caregiver Caregiver satisfaction caused changed Cluster condition Course Data collection E-health eight expected Health Health care Health care system health economics healthy implementation in-person visit include ISRCTN ISRCTN registry knowledge Low risk pregnancy majority Maternal Maternal outcomes midwife Neonatal Neonatal outcomes non-inferiority non-inferiority trial Obstetric outcomes pandemic Patient Patient satisfaction performed pregnant women protocol questionnaire Questionnaires Randomized randomized trial receive reduced Registered replaced REPLACED BY Research risk Risk assessment shift Study protocol Swedish Trial Virtual care women [DOI] 10.1186/s12884-022-04406-7 PMC 바로가기 [Article Type] Article
Seropositivity of Anti-SARS CoV2 IgG antibodies in health care workers of an Indian tertiary care hospital during COVID-19COVID-19 기간 동안 인도 3차 의료 병원의 의료 종사자에서 Anti-SARS CoV2 IgG 항체의 혈청 양성Article Published on 2022-04-012022-09-11 Journal: Indian journal of medical microbiology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Anti-COVID IgG antibodies antibody association Asymptomatic Asymptomatic case Asymptomatic cases Care Clinical data close contact COVID-19 Ct value Demographic and clinical data eight enrolled General population HCW HCWs Health care Health care worker health care workers higher risk hospital IgG antibody Infection patients with COVID-19 positive questionnaire rate of seroconversion respiratory respiratory sample RT- PCR RT-PCR SARS CoV2 SARS-CoV-2 IgG Sero-surveillance. Seroconversion Seropositivity serum sample serum samples statistically significant tested Viral was used [DOI] 10.1016/j.ijmmb.2022.02.004 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised, phase 1 trial합성 다항원 변형 백시니아 바이러스 앙카라 기반 COVID-19 백신(COH04S1)의 안전성 및 면역원성: 공개 및 무작위 배정, 1상 시험Clinical Trial Published on 2022-04-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] 95% CI Administered Adults Analysis Anxiety assigned baseline body-mass body-mass index boost Cellular responses center city Cohort Comprehensive Concentration COVID-19 vaccine development dose drug eight fatigue female Fever Fisher Fisher's exact test FIVE followed by foundation Future GRADE grade 3 Haematology healthy High dose High-dose Hope IgG immunogenicity immunological increase in initiated injection interferon interferon-γ Intramuscular injection less limit low dose low-dose medium dose modified vaccinia virus modified vaccinia virus Ankara Moss negative pregnancy test nine nucleocapsid nucleocapsid antigens nucleocapsid protein nucleocapsid-specific antibody Open-label outcome participant PCR test Phase 1 phase 1 trial Placebo placebo group plaque-forming unit plaque-forming units poxvirus pregnancy test Primary outcome provided randomised Randomly receive Registered reported risk Safety SARS-CoV-2 antibody SARS-CoV-2 neutralising antibodies SARS-CoV-2 neutralising antibody SARS-CoV-2 spike Secondary objectives secondary outcome secreting Seroconversion seroconversion rate seroconversion rates Seven severe adverse event severe adverse events Spike protein statistical T cell T cells T-cell responses titre Tolerability Trial troponin USA vaccination Vaccine Viral viral neutralisation was done was measured was tested [DOI] 10.1016/S2666-5247(22)00027-1 PMC 바로가기 [Article Type] Clinical Trial
Emerging of composition variations of SARS-CoV-2 spike protein and human ACE2 contribute to the level of infection: in silico approachesSARS-CoV-2 스파이크 단백질과 인간 ACE2의 조성 변화가 감염 수준에 기여함: in silico 접근법Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 angiotensin bind binding affinity binds bioinformatics calculated Combination contribute COVID-19 detect determine docking domain eight FIVE Genetic variant global energy hACE2 human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in silico in silico Approach in silico software Interaction investigated Laboratory moderate NCBI nsSNPs pandemic pathogenic PPI processed Protein Protein docking protein-protein interaction RBD RBD variant RBD variants Receptor-binding domain retrieved risk of infection SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein sequence similarity significantly SNP SNPs Support the binding affinity V367F V483A variant variants Variation zone [DOI] 10.1080/07391102.2020.1841032 PMC 바로가기 [Article Type] Article
Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects Research Published on 2022-04-012022-10-05 Journal: Nature Genetics [Category] 유전자 메커니즘, 진단, [키워드] aggregate Analysis association clinical manifestation collected complement coronavirus disease COVID-19 COVID-19 phenotype defined eight Genetic genetic association genetic component Genome-wide association study genome-wide significant GWASs loci Meta-analysis Mild Multiple outcome Participants performed phenotype Phenotypes Protective protective effect replication analysis reported Research risk severity susceptibility symptom severity therapeutic target These data [DOI] 10.1038/s41588-022-01042-x [Article Type] Research
Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progressionResearch article Published on 2022-04-012022-10-05 Journal: Heliyon [Category] 바이오마커, 진단, [키워드] Analysis average Biomarkers carried cause CD10 COVID-19 CRP demonstrated diagnostic Disease progression disease severity eight elevated expression feature hospital identify identifying IL-6 immature Immune phenotype immunological immunological characteristics Inflammation Laboratory lymphoid machine learning management marker monocyte myeloid cell Neutrophil maturity Neutrophils Patient positive SARS-CoV-2 PCR pro-inflammatory cytokine progression recruited risk factor routine SARS-COV-2 infection severe COVID-19 severe disease soluble CD25 were measured [DOI] 10.1016/j.heliyon.2022.e09230 [Article Type] Research article
Effect of SARs-CoV-2 pandemic on infection prevention behaviors and bacterial burden of high touch surfaces in a medical/surgical settingSARs-CoV-2 대유행이 의료/외과 환경에서 높은 접촉 표면의 감염 예방 행동 및 박테리아 부담에 미치는 영향Article Published on 2022-04-012022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] automated Bacterial carried Contamination correlated COVID-19 pandemic decrease detectable determine Effect Efficacy eight ENhance equipment estimates evaluated event Factor Final Frequency healthcare worker Healthcare workers hospital hygiene Infection Infection prevention Intervention lack Mild minimum offer pandemic participant pathogenic Patient Perception performed preference Prevention and control recruited reduction reported SARS-CoV-2 SARS-CoV-2 pandemic Stethoscope survey sustained the SARS-CoV-2 The United States Transmission ultraviolet United States while [DOI] 10.1038/s41598-022-09548-4 PMC 바로가기 [Article Type] Article