Genomic population structure associated with repeated escape of Salmonella enterica ATCC14028s from the laboratory into nature실험실에서 자연으로의 살모넬라 enterica atcc14028의 반복 탈출과 관련된 게놈 집단 구조Research Article Published on 2021-09-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Americas Analysis ancestor Bacteria bacteriophage bacteriophages bioterrorism British Isle British Isles caused clade Cluster Clustering Contamination core gene core genome cross-contamination Culture database Divergence element escaped event Evolution experiment fitness followed by gene transfer Genetic genetic diversity genomic genomic sequence genomic sequencing greater growth media HGT Hierarchical hierarchical clustering horizontal gene Horizontal gene transfer Human humans implicated individual Infection infections Ireland isolate Isolation Laboratory lack less life lineages multiple laboratories multiple laboratory National natural selection Neutral physically Plasmid plasmids Quality control repeated Salmonella sequence SNP storage storage condition storage conditions strain Strains Taiwan transfer Type culture [DOI] 10.1371/journal.pgen.1009820 PMC 바로가기 [Article Type] Research Article
The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular PerspectivePhysiology Published on 2021-09-272022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] 2019-nCoV/SARS-CoV-2 acute respiratory distress ARDS Blood cause COVID-19 COVID-19 infection COVID-19 patient disrupt element experiment hemoglobin homeostasis homeostatic Hypoxemia hypoxia hypoxia inducible factor Impact mechanism mechanisms membrane mitochondrial Mitochondrial function Novel coronavirus oxygen oxygen homeostasis oxygen transport Oxygenation parameters pathway Protein Proteins pulmonary dysfunction RBC RBCs red blood cell reported respiratory symptom syndrome therapeutic interventions understanding viral infection worsening [DOI] 10.3389/fphys.2021.711976 PMC 바로가기 [Article Type] Physiology
Patient Nutrition and Probiotic Therapy in COVID-19: What Do We Know in 2021?Review Published on 2021-09-262022-10-30 Journal: Nutrients [Category] COVID-19, SARS, [키워드] ACE2 receptor B12 cascade caused Cell consequence COVID-19 COVID-19 infection COVID-19 patient effective element Fatty acid fiber Gut immune response include individual Infection information inhibiting Malnutrition microbiota micronutrients nutrition nutritional status omega-3 outcome Patient patients hospitalized patients with SARS-CoV-2 Probiotic Probiotics Proinflammatory cytokine prophylactically Protein rapid muscle reduced SARS-CoV-2 Support the SARS-CoV-2 virus therapy Treatment turn virus Vitamin [DOI] 10.3390/nu13103385 PMC 바로가기 [Article Type] Review
Content and Communication of Inpatient Family Visitation Policies During the COVID-19 Pandemic: Sequential Mixed Methods StudyOriginal Paper Published on 2021-09-242022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS, [키워드] 5-point Likert scale 95% CI addressed Analysis analyzed Care communication Community conducted content COVID-19 COVID-19 pandemic element Ethics Evidence experiment exploratory expressed facility family family-centered care GRADE Guidance Health health communication health systems hospital policy hypothetical identify impair IMPROVE Inclusion initial Inpatient Level MOST objective pandemic participant Policy positive Primary outcome public health public perceptions Regulation Research Result significantly Support the United State The United States unique [DOI] 10.2196/28897 PMC 바로가기 [Article Type] Original Paper
Course and Survival of COVID-19 Patients with Comorbidities in Relation to the Trace Element Status at Hospital Admission입원 시 미량 원소 상태와 관련된 동반 질환이 있는 COVID-19 환자의 경과 및 생존Observational Study Published on 2021-09-222022-09-10 Journal: Nutrients [Category] SARS, 바이오마커, 임상, [키워드] Adults Anti-viral association Belgium Biomarker Cancer cardiac disease Cell chronic cardiac disease clinical care co-morbidities Comorbidities Concentration conducted contribute Course COVID-19 COVID-19 patient cross-sectional death deficiency diabete diabetes disease course disease severity Diseases element European Ghent healthy hospital Hospital admission immune system Infectious diseases Micronutrient Mild morbidities mortality rate mortality risk nutrition obese obese patient obese patients observational study outcome Patient patients with COVID-19 plasma predict relation responses risk Selenium SELENOP serum severe COVID-19 severe disease course status Stratification study group Support the patient therapeutic intervention therapeutic interventions trace Trace element trace elements Zinc [DOI] 10.3390/nu13103304 PMC 바로가기 [Article Type] Observational Study
Patients’ Habits and the Role of Pharmacists and Telemedicine as Elements of a Modern Health Care System during the COVID-19 PandemicArticle Published on 2021-09-172022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] absence addition Care clinics conducted Contact COVID-19 COVID-19 pandemic COVID-19 vaccination disease E-health electronic medical record element face-to-face contact Government growth habit Health health information healthcare Healthcare system help hospital implementation increase in integration Internet introduced investigated limitations material medication Modification MOST New coronavirus outbreak Patient Patient care Patient satisfaction Pharmaceutical care Pharmacist Pharmacy Poland provided public health questionnaire role System Telemedicine the epidemic the patient vaccinated against COVID-19 vaccination WHO World Health Organization [DOI] 10.3390/jcm10184211 PMC 바로가기 [Article Type] Article
Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients중환자 COVID-19 환자의 치명적인 결과의 면역 상관 관계 식별Research Article Published on 2021-09-162022-09-10 Journal: PLoS Pathogens [Category] 바이오마커, 진단, [키워드] 95% CI abnormality Activation CCL2 CD8 cell activation cells chemokines controls correlated COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Critical Critical illness Critically ill Critically ill patient critically ill patients CXCL10 cytokine Cytokines death death in COVID-19 demonstrated disease severity driven by driver dysfunction ECMO element elements elevated examined fatal COVID-19 GM-CSF Health care health care workers healthy hierarchy ICU ICU patient ICU Patients identification identify IFNα IL-6 immune immune correlate Immunophenotyping in-depth analysis independent Infection Inflammatory response Influenza influenza infection Intervention measure Neutralizing antibodies outcome pathway Patient performed Potential biomarker pro-inflammatory response prognostic indicator Proteins reveal RNA-sequencing SARS-COV-2 infection serum Serum protein serum proteins shift Single-cell RNA-sequencing T cell T cell activation T cell responses T cells target unique Viral Viral antigen [DOI] 10.1371/journal.ppat.1009804 PMC 바로가기 [Article Type] Research Article
Epidural morphine in COVID ARDS patients with high respiratory drive: a structured summary of a study protocol for a randomised controlled trial높은 호흡 드라이브가 있는 COVID ARDS 환자의 경막외 모르핀: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-09-162022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 28-day mortality Abnormalities acceptance administer Administered Admission Adult patient Adult patients allocation ARDS patient aseptic technique assistant average blind Blinding both group both groups catheterization Coagulation comparator Patients control group COVID COVID 19 patient COVID 19 patients COVID-19 criteria CTRI death discharge dissemination dose doses double blind Dyspnoea element Endotracheal intubation Epidural epidural catheter Epidural morphine epidural space Escalation exclusion criteria fixed fraction greater Group allocation HCO hypoventilation Hypoxemia ICU ICU patient inclusion criteria India injection Intervention intervention group intubation involved list Local maximum mechanical ventilation Medical Science Medical Sciences Metabolic acidosis minimum morphine morphine sulphate Mortality NIV non-invasive ventilation number Nurse objective outcome Pain parameters participant Patient Patient self-induced lung injury patients with COVID19 physician Placebo protocol random randomisation randomised randomised controlled trial recruited reduce Registered registry Research respiratory respiratory acidosis Respiratory drive respiratory parameters resulting Sample size sealed second dose secondary Secondary outcomes Sedation Sepsis severe hypoxemia sitting position skin Source Study protocol sulphate supplementary material team the patient Trial ventilator parameters website with COVID-19 [DOI] 10.1186/s13063-021-05570-5 PMC 바로가기 [Article Type] Letter
Prophylactic potential of honey and Nigella sativa L. against hospital and community-based SARS-CoV-2 spread: a structured summary of a study protocol for a randomised controlled trial병원 및 지역사회 기반 SARS-CoV-2 확산에 대한 꿀과 Nigella sativa L.의 예방 가능성: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-09-152022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 adaptive allergy analyst approved asymptomatic patient blinded Blinding body weight Botany Care care providers chronic infection clinic clinical Clinical management clinical study clinical trial college Community conflict conflict of interest control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19-related symptom COVID-19-related symptoms death defined dextrose dissemination doctor Efficacy element Endpoint enrolled evaluate excluded exposure to Final futility high risk Honey hospital hospitalizations incidence include institutional review board Intention interim analysis investigator management guidelines masking moderate National Health Service Nigella Nigella Sativa number objective outcome Pakistan parallel group participant Participants Patient patients per day Placebo placebo group placebo-controlled Primary outcome principal investigator Prophetic Medicine Prophylactic protocol randomisation randomised randomised controlled trial randomization Randomized receive recruited recruitment Registered reported responsible risk Sample size SARS-CoV-2 screened secondary Secondary endpoints severity Site Standard standard care Standardization status Stratification Study protocol supplementary material the patient therapeutic potential therapy Trial university Version water website [DOI] 10.1186/s13063-021-05510-3 PMC 바로가기 [Article Type] Letter
Risk factors for invasive aspergillosis in ICU patients with COVID-19: current insights and new key elementsReview Published on 2021-09-152022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress syndrome Admission Antibiotics article association CAPA Characteristics chronic condition Chronic kidney disease Comorbidities concerning conditions Corticosteroid Corticosteroids Course COVID COVID-19 COVID-19-associated pulmonary aspergillosis Critically ill patient diabetes Diagnosis diagnostic disease element environmental factors epidemiological evaluate Factor Factors feature hospital Host ICU ICU patient Immunomodulatory agents influenza infection intensive care intensive care unit invasive Invasive pulmonary aspergillosis IPA Isolation Liver cirrhosis management mechanical ventilation Non-invasive respiratory support Obstructive pandemic potential risk Prolonged Prospective Study pulmonary disease reported respiratory diseases Reviewing risk factor Risk factors SARS-CoV-2 SARS-CoV2 infection severe immunosuppression shifting Spread Surveillance Therapeutic approach Therapies therapy treat Treatment Ventilation [DOI] 10.1186/s13613-021-00923-4 PMC 바로가기 [Article Type] Review