A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate BindingSARS-CoV-2의 스파이크 수용체 결합 도메인과 친밀한 결합의 구조적 기초를 표적으로 하는 강력한 중화 나노바디Article Published on 2022-05-182022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Basis binding binding affinity binding site biochemical analyses characterization competing complex coronavirus delta variant Diseases domain drug candidates engage epitope In-vitro increase nanobodies nanobody neutralization neutralization activity Neutralizing overlapping potent Potential treatment raised receptor related diseases respiratory reveal S-RBD SARS-CoV-2 SARS-CoV-2 S severe acute respiratory syndrome Coronavirus spike receptor-binding domain Spread structural basis target targeting the Spike These data Viral viral spike virus [DOI] 10.3389/fimmu.2022.820336 PMC 바로가기 [Article Type] Article
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functionsmRNA-1273 및 BNT162b2 COVID-19 백신은 Fc 매개 효과기 기능에 차이가 있는 항체를 유도합니다Article Published on 2022-05-182022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody approved binding BNT162b2 cell activation Cohort Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Efficacy elicit epitope evade Fc-mediated effector function function functional functional capacity Hospital staff humoral immune response humoral immune responses IgA immune response immune responses Killer cell morbidity morbidity and mortality mRNA mRNA vaccines mRNA-1273 mRNA-1273 vaccine mRNA-1273 vaccines N-terminal N-terminal domain natural killer natural killer cell neutralization Neutralizing antibodies neutrophil phagocytosis potential differences protective immunity RBD Receptor binding domain recipient recipients reduced Region respiratory responses robust SARS-CoV-2 the vaccine the vaccines These data Vaccine Vaccines variants variants of concern Variation Viral viral variant Viral variants wake wild-type [DOI] 10.1126/scitranslmed.abm2311 PMC 바로가기 [Article Type] Article
Vaccine-induced systemic and mucosal T cell immunity to SARS-CoV-2 viral variantsSARS-CoV-2 바이러스 변이체에 대한 백신 유도 전신 및 점막 T 세포 면역Article Published on 2022-05-172022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] absence antibodies B1.351 CD4 CD4 T cell CD4 T cells CD8 T cell CD8 T cells CLARITY conserved COVID-19 vaccine Critical detectable effective Effectiveness elicit epitope Epitopes evade homologous Hospitalization Immunity immunization implication Infection knowledge lack lung immunopathology Lung pathology memory memory T cell memory T cells mucosal neutralized Neutralizing antibodies presence of antibody presence or absence PROTECT Protective protective vaccines provided SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral T cell T cell responses T cells Vaccine variant Viral viral control virus virus-neutralizing antibodies [DOI] 10.1073/pnas.2118312119 PMC 바로가기 [Article Type] Article
Molecular Analysis of SARS-CoV-2 Lineages in Armenia아르메니아에서 SARS-CoV-2 계통의 분자 분석Article Published on 2022-05-172022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Alpha) affected Alpha Analysis Armenia caused circulation clade coronavirus COVID-19 Delta Epidemiology epitope Epitopes functional Genome genomic HLA Illumina Illumina sequencing information Lineage loci molecular Molecular epidemiology Mutation N gene N genes Nanopore nanopore sequencing omicron ORF1 ORF1ab PCR test PCR tests performed positive Protective provide Research RT-PCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sequences Sequencing short-read sequencing signal specific clade specific clades Surveillance Transmission utility variants Viral viral evolution virus whole-genome sequencing [DOI] 10.3390/v14051074 PMC 바로가기 [Article Type] Article
A Novel Human Neutralizing mAb Recognizes Delta, Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab새로운 인간 중화 mAb는 SARS-CoV-2의 델타, 감마 및 오미크론 변이체를 인식하고 소트로비맙과 함께 사용할 수 있습니다Article Published on 2022-05-162022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin angiotensin converting enzyme anti-spike MAbs antibody Can Casirivimab caused Cell culture cell cultures cell entry Clinical use combinatorial treatment combinatorial treatments coronavirus Delta diagnostic drug ENhance epidemics/pandemics epitope Epitopes Gamma glycoprotein Human Imdevimab immune system Infection inhibitory effect Interaction interfere investigated mAb mAbs monoclonal monoclonal antibodies Neutralizing Neutralizing activity neutralizing mAbs. novel omicron Omicron variant pandemic Pandemics Patient RBD Receptor binding domain recognize recognizing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus Scientific community Sotrovimab spike spike glycoprotein Spike-RBD/ACE-2 subsequent the antibody the Spike therapeutic therapy variants virus virus infection [DOI] 10.3390/ijms23105556 PMC 바로가기 [Article Type] Article
A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants멀티토프 SARS-CoV-2 백신은 Delta 및 Omicron 변이체에 대해 오래 지속되는 B 세포 및 T 세포 면역을 제공합니다Clinical Trial Published on 2022-05-162022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] adverse event Antibody titers Asia B cell booster Breakthrough infection breakthrough infections center conducted conserved Control COVID-19 cross-reactive cytotoxic T lymphocyte Delta disease control dose elicited epitope Epitopes evaluated fatigue healthy helper T cell Heterologous human convalescent sera Immunity immunization immunogenicity Inc. injection site pain long-lasting lymphocyte membrane memory immunity Mild Ministry of Health Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer nucleocapsid omicron Omicron variants peptide peptides Phase I placebo-controlled Protein provide Randomized representing responsible safety profile sarbecovirus SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second dose Serious Adverse Event Serious Adverse Events subunit Subunit vaccine T cell Taiwan Trial trials Vaccine variant variants of SARS-CoV-2 virus-neutralizing antibody VOCs waning immunity Welfare were recorded [DOI] 10.1172/JCI157707 PMC 바로가기 [Article Type] Clinical Trial
Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigensCD8+ T 세포 병원성 에피토프 및 암 신생항원 예측에서 기존 컴퓨터 모델의 성능 평가Article Published on 2022-05-132022-09-12 Journal: Briefings in Bioinformatics [Category] MERS, 진단, [키워드] acute respiratory syndrome binding affinity Cancer cancer neoantigen cancers CD8 T-cell CD8 T-cell target CD8+ T cell coronavirus disease distribution epitope evaluated Evaluating Evidence facilitate Factor feature highlight histocompatibility complex HLA ligand immunogenic immunogenic peptide immunotherapies Immunotherapy Intensive long-term immune responses malignant cell modulate offer parameter pathogen pathogenic pathology peptide peptide immunogenicity peptide presentation peptides predictors question random Research robust stability suggested T cell T cell receptor T-cell T-cell Response target threshold training data Vaccine Variation virus [DOI] 10.1093/bib/bbac141 PMC 바로가기 [Article Type] Article
Humoral Immune Response Diversity to Different COVID-19 Vaccines: Implications for the “Green Pass” Policy다양한 COVID-19 백신에 대한 체액 면역 반응 다양성: "그린 패스" 정책에 대한 시사점Article Published on 2022-05-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACE2 binding activities Ad26 Ad26.COV2.S age Analysis anti-RBD anti-RBD antibody titer antibody Antibody Response Antibody titer appear assumption average binding BNT162b2 booster vaccination ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine ChAdOx1 nCoV-19 vaccines concentrations country COV2.S COVID-19 COVID-19 infection COVID-19 pandemic detect Diversity elicit elicited eligibility epitope evaluated Features green Green Pass Policy heterogeneous humoral humoral immune response immune Immunity implication individual maintain mRNA mRNA-1273 Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody observé Pass peptides Policy Protein Randomly Rapid test rationale RBD RBD-ACE2 reactivity reactogenicity Receptor-binding domain reduce reopening response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike selected sera serum serum sample significantly spike Spike protein synthetic peptide the receptor-binding domain titer vaccinated individual vaccination Vaccine virus spread [DOI] 10.3389/fimmu.2022.833085 PMC 바로가기 [Article Type] Article
Profiling of hMPV F-specific antibodies isolated from human memory B cells Research Published on 2022-05-102022-10-05 Journal: Nature Communications [Category] 변종, [키워드] antibody Antibody Response Antigen antigenic site binding binding mode defined dominant epitope Epitopes glycoprotein human donors human metapneumovirus immune Infection less mAb mAbs majority memory B cell monoclonal antibody neutralization neutralization potency Neutralizing neutralizing antibody neutralizing epitope prefusion Profiling recognize respiratory syncytial virus RSV Specificities Vaccine development [DOI] 10.1038/s41467-022-30205-x [Article Type] Research
Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2SARS-CoV-2에 대한 비교차 반응성 T 세포 반응의 정확한 검출을 위한 면역원성 에피토프 패널Article Published on 2022-05-092022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence Accuracy Antigen antigens association Asymptomatic clinical clinical trial clinical trials Cohort collected Combination Complete contributing to convalescent COVID-19 COVID-19 pandemic cross-reactive described diagnostic Diagnostic accuracy diagnostic specificity donors effective epitope Epitopes exclusion full-length healthy HLA HLA allele Immune cell immune cells immunodominant immunogenic immunogenicity in vitro independent individual individuals offered peptides PROTECT reactivity robust SARS-CoV-2 SARS-CoV-2 immunity sensitivity seronegative specificity T cell T cell response T cells [DOI] 10.1172/jci.insight.157699 PMC 바로가기 [Article Type] Article