Skewed Cytokine Responses Rather Than the Magnitude of the Cytokine Storm May Drive Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children사이토카인 폭풍의 크기보다는 편향된 사이토카인 반응이 어린이의 다기관 염증 증후군에서 심장 기능 장애를 유발할 수 있음Article Published on 2021-08-172022-09-11 Journal: Journal of the American Heart Association [Category] 바이오마커, [키워드] absolute levels Acute stress analyzed association cardiac Cardiomyopathy children controls correlated COVID‐19 cytokine Cytokine storm Cytokines deformation diastolic drive driven by dysfunction echocardiographic parameter echocardiographic parameters echocardiography Elevation elevations etiology evaluated explained expression feature hypercytokinemia hyperinflammation immune response impairment Inflammatory interleukin interleukin-6 interleukin-8 involved microangiopathy MIS-C multisystem inflammatory syndrome in children Myocardial myocardial deformation. Myocardial function myocardial involvement outcome parameter Pathways Primary outcomes profile profiles proinflammatory cytokines response Result severity Shock storm strain syndrome systolic ventricular [DOI] 10.1161/JAHA.121.021428 PMC 바로가기 [Article Type] Article
SELP Asp603Asn and severe thrombosis in COVID-19 malesSELP Asp603Asn 및 COVID-19 남성의 심각한 혈전증Letter to the Editor Published on 2021-08-162022-09-10 Journal: Journal of Hematology & Oncology [Category] MERS, SARS, 변종, [키워드] 95% CI Adhesion Molecule adjusted adjuvant therapy age androgen Androgen receptor Anti-selectin P monoclonal antibodies antibody Cell cell adhesion molecule coding variant Cohort confidence confidence interval COVID-19 D-dimer downregulated etiology Exome GEN-COVID homozygosity homozygote interval Logistic regression male Mortality Odds ratio Older P-selectin rationale receptor repurposing SARS-CoV-2 SELP Sequencing severity stratified by sex subject subjects supplementary material Testosterone the cell therapy Thromboembolism thrombosis thrombotic thrombotic risk Thrombus Venous Thromboembolism [DOI] 10.1186/s13045-021-01136-9 PMC 바로가기 [Article Type] Letter to the Editor
Miller-Fisher Syndrome Presenting as Facial Diplegia With COVID-19 Co-InfectionEmergency Medicine Published on 2021-08-102022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Ataxia Brain cerebrospinal fluid Computed tomography Coronavirus disease 2019 Course COVID-19 COVID-19 infection demonstrated Diagnosis diplegia etiology facial facial diplegia facial palsy Guillain-Barré syndrome Intravenous immunoglobulin miller-fisher syndrome neurological manifestations Patient physical SARS-COV-2 infection serology test Support supported therapy unique variant [DOI] 10.7759/cureus.17060 PMC 바로가기 [Article Type] Emergency Medicine
Update Advances on C-Reactive Protein in COVID-19 and Other Viral InfectionsImmunology Published on 2021-08-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, 신종인플루엔자, [키워드] adaptive advance Antibiotic therapy appear Bacterial sepsis C-reactive protein C-reactive protein (CRP cause clearance Clinical diagnosis Complication contribute coronavirus disease COVID-19 COVID-19 virus Critical CRP disease Disease progression Diseases elevated Escalation etiology explain highlight Host host innate immunity hyperinflammation illnesses Immunity in viral infections Inflammation inflammatory mediator inflammatory status information macrophage activation syndrome marker measure mechanical ventilation Mild mitigate Multiorgan dysfunction non-infectious Other outcome Pathogenesis Pathologies Predictive Prevent procalcitonin progression Protein Proteins responses serum CRP severe COVID-19 the disease translated Treatment viral infection viral infections viral-induced [DOI] 10.3389/fimmu.2021.720363 PMC 바로가기 [Article Type] Immunology
Neuroimmunology and Novel Methods of Treatment for Acute Transverse MyelitisNeurology Published on 2021-08-092022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute transverse myelitis addition age ATM Biomarker blocker Cell clinical trial defined described Diagnostic Criteria etiology fampridine highlight immunomodulatory therapy immunopathology Immunosuppressive agents Inflammatory response Injury Myelitis Neuroimmunology neurologic novel outcome pathophysiology plasma exchange therapy Potassium Potential treatment Radiographic Research restricted progenitor cells therapeutic Transverse Treatment [DOI] 10.7759/cureus.17043 PMC 바로가기 [Article Type] Neurology
Duration of post–COVID-19 symptoms is associated with sustained SARS-CoV-2–specific immune responses코로나19 이후 증상의 지속 기간은 지속적인 SARS-CoV-2 특정 면역 반응과 관련이 있습니다.Research Article Published on 2021-08-092022-09-12 Journal: JCI Insight [Category] MERS, SARS, 진단, [키워드] Adaptive immunity antibody Antigen CD4 cell population circulating correlation COVID-19 COVID-19 patient COVID-19 symptom COVID-19 symptoms demonstrated Duration etiology evaluated expected follicular groups helper cell IgG immune cell types immune response immune responses immune signature immunology individual investigated magnitude marker median PASC Patient Peripheral blood persistence phenotypic resolved SARS-COV-2 infection SARS-CoV-2 spike protein Significant Spike protein subset sustained Symptom symptom duration symptom resolution systemic inflammation T cell T cell response T cells Viral antigen viral antigens [DOI] 10.1172/jci.insight.151544 PMC 바로가기 [Article Type] Research Article
Disappearance of Seasonal Respiratory Viruses in Children Under Two Years Old During COVID-19 Pandemic: A Monocentric Retrospective Study in Milan, ItalyPediatrics Published on 2021-08-052022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] adopted affected age analyzed average Care center children Containment measure COVID-19 COVID-19 pandemic cytomegalovirus diagnosed disappearance enrolled enterovirus Epidemiology etiology female Hospitalization Hospitalized incidence Infection IQR Italy Lower respiratory tract male median Modification nasopharyngeal Patient Poisson distribution public health reduction reduction in respiratory respiratory viruses seasonal significant difference Viral detection virus Year [DOI] 10.3389/fped.2021.721005 PMC 바로가기 [Article Type] Pediatrics
Acute pancreatitis as an atypical manifestation of COVID-19: A report of 2 casesCase Report Published on 2021-08-052022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] ACE-2 acute pancreatitis acute respiratory distress association Atypical complications Conservative management COVID COVID-19 COVID-19 infection CT findings Cytokine storm death digestive ECMO etiology Evolution exhibited expression full recovery highlight Laboratory manifestation Manifestations mechanical ventilation occur outcome pancrea pancreatic Pancreatitis Patient physiopathological mechanism reported respiratory respiratory manifestation respiratory symptom severe complications suffered suggested Symptom the patient virus worsening [DOI] 10.1016/j.amsu.2021.102693 PMC 바로가기 [Article Type] Case Report
Chest CT texture-based radiomics analysis in differentiating COVID-19 from other interstitial pneumonia흉부 CT 텍스처 기반 방사선 분석은 COVID-19를 다른 간질 성 폐렴과 차별화합니다.Chest Radiology Published on 2021-08-042022-09-01 Journal: La Radiologia Medica [Category] MERS, 진단, [키워드] Analysis analyzed Chain Reaction characteristic Chest CT Combination Computed tomography consecutive patient Consensus coronavirus coronavirus disease COVID-19 COVID-19 negative COVID-19 patients COVID-19 pneumonia COVID-19 positive patient COVID-19 positive patients criteria CT finding CT findings Department Diagnostic Criteria Diagnostic tool Emergency emergency department enrolled Entropy etiology evaluate feature filtered identify intensity interstitial pneumonia Mann–Whitney test material medium negative patients Patient patients performed Pneumonia polymerase chain polymerase chain reaction positive positive COVID-19 positive patients radiologist receiver operating characteristic Result reverse transcription reverse transcription polymerase chain reaction ROC RT-PCR sensitivity specificity Standard deviation Texture analysis the patient [DOI] 10.1007/s11547-021-01402-3 PMC 바로가기 [Article Type] Chest Radiology
Clinical Characteristics and Outcome of Patients with Suspected COVID-19 in Emergency Department (RESILIENCY Study II)Article Published on 2021-07-292022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] 30-Day mortality 30-day mortality rate Acute heart failure Acute respiratory failure Bacterial cause causes Characteristics clinical COVID-19 COVID-19 group COVID-19 patient Decision tree Department detect Diagnosis diagnosis of COVID-19 dry cough Dyspnea Emergency etiologies etiology evaluated ferritin Fever First wave help Hospitalization Hospitalized hospitalized COVID-19 patient IMPROVE infective Kaplan–Meier Laboratory lymphocyte management Mortality Multivariate analysis non-COVID-19 group non-COVID-19 patient outcome pandemic Patient patients patients hospitalized performed physician Pneumonia primary endpoint Prospective Study protocol radiological recruited SARS-CoV-2 SARS-COV-2 infection second wave study period survival Suspected Symptom variable with COVID-19 [DOI] 10.3390/diagnostics11081368 PMC 바로가기 [Article Type] Article