Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon responseSARS-CoV-2의 게놈 모니터링은 I형 인터페론 반응을 조절하는 Nsp1 결실 변이체를 밝혀냅니다Article Published on 2021-03-102022-09-11 Journal: Cell Host & Microbe [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 진단, [키워드] approach association calu-3 cells causative agent clinical phenotype clinical phenotypes clinical sample clinical samples country COVID-19 cycle threshold Deletion deletion variant Deletion variants diagnostics drug design Epidemiology experimental validation Genetic genetic diversity genetic variants genetics genomic Genomic epidemiology IFN-β induce infected patients interferon locus modulate molecular molecular diagnostics Mutation nsp1 response reverse genetics RT-PCR SARS-CoV-2 SARS-CoV-2 virus sequenced sample Sequencing serum severity Surveillance type I interferon variant variants virus virus genome viruses [DOI] 10.1016/j.chom.2021.01.015 PMC 바로가기 [Article Type] Article
Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis비오코 섬, 적도 기니의 말라리아 원충(Plasmodium falciparum)에서 트롬보스폰딘 관련 접착 단백질(TRAP) 유전자의 유전적 다양성과 자연 선택 및 글로벌 비교 분석Research Published on 2021-03-022024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] Bioko Island genetic diversity malaria natural selection Plasmodium falciparum thrombospondin-related adhesive protein (PfTRAP) vaccine candidate [DOI] 10.1186/s12936-021-03664-8 PMC 바로가기 [Article Type] Research
Animal Coronaviruses Induced ApoptosisReview Published on 2021-02-262022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Adaptive immune response Alter animal animal coronavirus Animal coronaviruses antiviral target Apoptosis apoptotic pathway apoptotic pathways apoptotic signaling Cell cell death cell type cellular homeostasis cellular response clade coronavirus Coronavirus infection Critical death Evidence expected Future genetic diversity help host cell hosts identify induced Infection innate immune Interaction knowledge limit mechanism modulation molecular molecular mechanism pathogen Pathways proliferation promote recent Regulation Research SARS-CoV SARS-COV-2 infection Viral protein viral replication viruses [DOI] 10.3390/life11030185 PMC 바로가기 [Article Type] Review
Genetic characterization of Plasmodium vivax isolates from Pakistan using circumsporozoite protein ( pvcsp) and merozoite surface protein-1 ( pvmsp-1 ) genes as genetic markers파키스탄에서의 Plasmodium vivax 분리체의 유전적 특성 분석: 유전적 마커로서의 circumsporozoite 단백질 (pvcsp) 및 merozoite 표면 단백질-1 (pvmsp-1) 유전자 사용Research Published on 2021-02-252024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] CSP genetic diversity malaria Msp-1 Plasmodium vivax [DOI] 10.1186/s12936-021-03654-w PMC 바로가기 [Article Type] Research
Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity우간다 인구에서 역사적으로 다양한 말라리아 전파 강도에 따른 KIR 유전자와 HLA-C 리간드의 다양성Research Published on 2021-02-252024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] genetic diversity human leukocyte antigen killer-cell immunoglobulin-like receptor malaria Uganda [DOI] 10.1186/s12936-021-03652-y PMC 바로가기 [Article Type] Research
Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patientsCOVID-19 환자에서 SARS-CoV-2 집단의 숙주 내 변이 및 진화 역학Research Published on 2021-02-222022-08-13 Journal: Genome Medicine [Category] MERS, 변종, 유전자 메커니즘, [키워드] allele frequency analyzed anatomic site bottleneck bottleneck events bottlenecks causative agent characterized collected Consensus consensus genome coronavirus COVID-19 COVID-19 patient death distribution driven by Dynamics eight event Evolution evolutionary dynamics gastrointestinal tract Genetic genetic diversity Genotype High-throughput sequencing Intra-host Intra-host variant iSNV iSNVs knowledge metatranscriptomic MOST Mutation nucleotide Patient patients with COVID-19 polymorphic site Population populations respiratory respiratory tract Result RNA viruses SARS-CoV-2 SARS-CoV-2 genome Sequencing Single nucleotide variant single nucleotide variation supplementary material the SARS-CoV-2 genome variants Variation Viral virus Virus-host interaction Virus-host interactions [DOI] 10.1186/s13073-021-00847-5 PMC 바로가기 [Article Type] Research
SARS-CoV-2 genetic diversity in Venezuela: Predominance of D614G variants and analysis of one outbreak베네수엘라의 SARS-CoV-2 유전적 다양성: D614G 변이의 우세 및 한 발병 분석Research Article Published on 2021-02-192022-09-10 Journal: PLoS ONE [Category] MERS, 변종, 치료기술, [키워드] Amino acid amino acids Analysis circulating Complete coronavirus COVID-19 COVID-19 disease D614G mutation D614G variant Deletion deletions Frame Frequency Genetic genetic diversity Genome genomic highest in-frame deletion island isolate isolates Lineage Margarita N-terminal domain New coronavirus nsp1 occurred ORF1 outbreak Patient Protein Region regions responsible Sanger sequencing SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolate SARS-CoV-2 isolates sequence Spike protein strain Structural analysis the epidemic the Spike Venezuela whole genome [DOI] 10.1371/journal.pone.0247196 PMC 바로가기 [Article Type] Research Article
Parasite genetic diversity reflects continued residual malaria transmission in Vhembe District, a hotspot in the Limpopo Province of South Africa기생충 유전적 다양성은 남아프리카 림포포 주의 핫스팟인 베헴베 지구에서 지속적인 잔여 말라리아 전파를 반영합니다.Research Published on 2021-02-162024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] genetic diversity Limpopo Microsatellites multiplicity of infection Plasmodium falciparum Residual transmission South Africa Vhembe District [DOI] 10.1186/s12936-021-03635-z PMC 바로가기 [Article Type] Research
Early Diffusion of SARS-CoV-2 Infection in the Inner Area of the Italian Sardinia IslandMicrobiology Published on 2021-02-122022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome addition affected amino acid substitution amino acid substitutions Analysis Area clinical sample Cluster Complete coronavirus coronavirus disease COVID-19 death early phase eight epidemiological Epidemiology European country genetic diversity Genome sequencing genomes genomic geographical distribution homogeneous hospital incidence Infection information initial Inner island Italian Italian patient Italy Local lowest molecular characterization outbreak pandemic Phylogenetic Phylogeny Prevalence provide Region reported responsible Result Sardinia Sardinia Island SARS-CoV-2 SARS-CoV-2 viral sequence Sequencing severe pneumonia the SARS-CoV-2 viral genome was performed Wuhan, China [DOI] 10.3389/fmicb.2020.628194 PMC 바로가기 [Article Type] Microbiology
Molecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E Genogroup홍콩에서 인간 코로나바이러스 229E의 분자 진화와 새로운 인간 코로나바이러스 229E 유전자 그룹과의 동시 감염을 포함하는 치명적인 COVID-19 사례Case Reports Published on 2021-02-102022-09-10 Journal: mSphere [Category] MERS, 진단, 치료기술, [키워드] 229E addition airway Analysis camelid circulating CLOCK Clustering Coinfection COVID-19 COVID-19 pneumonia described diagnose disease domain Evolution Genetic genetic diversity genetic drift Genome sequencing Genotype HCoV HCoV-229 HCoV-229E Hong Kong human coronavirus human coronavirus 229E human coronaviruses identity infected patients Involving N gene nasopharyngeal sample novel nucleotide path patients Pneumonia positive Positive selection RdRP Receptor-binding domain related viruses required respiratory respiratory sample retrieved SARS-CoV-2 SARS-CoV-2 strain Sequence analysis Sequencing Spike protein strain Strains tested the patient the SARS-CoV-2 the spike protein the United State The United States Transmission Travel type strain United States Viral viral evolution virus viruses Wuhan Wuhan-Hu-1 [DOI] 10.1128/mSphere.00819-20 PMC 바로가기 [Article Type] Case Reports