Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam베트남 하노이에서 SARS-CoV-2의 유전적 다양성과 COVID-19 환자의 임상, 역학적 특성Research Article Published on 2020-11-172022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] accompanied Admission analysed Asia B.1.1 lineage Characteristics China circulating Cluster country COVID-19 case COVID-19 patient Cycle threshold value D614G diarrhoea disease severity dominant dry cough epidemiological Europe European European country Fever Genetic variant genomes hospitalisation Illumina Illumina Miseq Local male median median age MOST Mutation mutations NC_045512 New Nsp12 P323L Patient positive patient Prevalence reference sequence reflected Result Russia SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RT-PCR sequence homology sequenced sore throat strain Strains Symptom transition Tropical Diseases variant viruses [DOI] 10.1371/journal.pone.0242537 PMC 바로가기 [Article Type] Research Article
Analysis of the potential impact of genomic variants in global SARS-CoV-2 genomes on molecular diagnostic assaysShort Communication Published on 2020-11-092023-06-15 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, [키워드] COVID-19 genomes Gibbs free energy reverse transcription polymerase chain reaction SARS-CoV-2 variations [DOI] 10.1016/j.ijid.2020.10.086 PMC 바로가기 [Article Type] Short Communication
Variant analysis of 1,040 SARS-CoV-2 genomes1,040 SARS-CoV-2 게놈의 변이체 분석Research Article Published on 2020-11-052022-08-13 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] Analysis bases coding sequences Comparative analysis Complete detect GenBank Genome genomes intergenic region intergenic regions isolate Mutation performed respiratory RNA virus SARS-CoV-2 SARS-CoV-2 genome sequences Sequencing Severe acute respiratory syndrome untranslated region UTR variant variants Viral viral genome whole genome Whole genome sequencing [DOI] 10.1371/journal.pone.0241535 PMC 바로가기 [Article Type] Research Article
Comprehensive evolution and molecular characteristics of a large number of SARS-CoV-2 genomes reveal its epidemic trends다수의 SARS-CoV-2 게놈의 포괄적인 진화 및 분자적 특성이 전염병 경향을 나타냅니다.Article Published on 2020-11-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis change Characteristics classification Comprehensive coronavirus correlated death rate Epidemic Epidemiology Europe Evolution Frequency Genome genomes Haplotype haplotypes indicated Ka/Ks major haplotype molecular Neutral nine Non-synonymous pathogenicity Phylogenetic Population size respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes severe acute respiratory syndrome Coronavirus subgroup synonymous Treatment whole genome [DOI] 10.1016/j.ijid.2020.08.066 PMC 바로가기 [Article Type] Article
Substitutions in Spike and Nucleocapsid proteins of SARS-CoV-2 circulating in South America남미에서 순환하는 SARS-CoV-2의 스파이크 및 뉴클레오캡시드 단백질의 치환Article Published on 2020-11-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 치료법, [키워드] ACE Algorithm Amino acid Betacoronavirus Brazil circulating collected conserved country COVID-19 diagnostic assay COVID-19 pandemic D614G diagnostic tests Ecuador Epidemic Frequency genetic variability Genome genomes genomic Genomic surveillance genus genus Betacoronavirus high affinity human population Illumina Miseq immunogenic infect information Lower respiratory tract muscle N protein Non-synonymous substitutions nucleocapsid nucleotide nucleotide sequence Oxford pandemic Protein Proteins protocol receptor replaced REPLACED BY reported respiratory responsible SARS-CoV-2 SARS-CoV-2 pandemic sequence sequences Seven South South America spike Spike protein structural protein structural proteins Substitution substitutions Surveillance synonymous substitutions the SARS-CoV-2 the spike protein Therapeutics Vaccines virus [DOI] 10.1016/j.meegid.2020.104557 PMC 바로가기 [Article Type] Article
Genome-Wide Analysis of the Malaria Parasite Plasmodium falciparum Isolates From Togo Reveals Selective Signals in Immune Selection-Related Antigen Genes토고에서의 말라리아 기생충 플라스모디움 팔시파룸 분리주의 게놈 전반 분석은 면역 선택 관련 항원 유전자에서 선택적 신호를 드러낸다Original Research Published on 2020-10-232024-08-11 Journal: Frontiers in immunology [Category] 말라리아, [키워드] balancing selection directional selection genomes Immunity Plasmodium falciparum Togo [DOI] 10.3389/fimmu.2020.552698 PMC 바로가기 [Article Type] Original Research
Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responsesArticle Published on 2020-10-202022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome Affect cell line coronavirus Cytokines cytosine downstream enzyme Enzymes Factor gene mutation genomes guanine Host IL-6 immunology Impact induce Infection Inflammatory cytokine Inflammatory response mutated Mutation mutations Pathogenesis Point Point mutation prevalent Proofreading resulting RNA RNA viruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence severe pneumonia specificity ssRNA stimulate TNF-α upstream uracil variants of SARS-CoV-2 virus worldwide pandemic Wuhan [DOI] 10.1038/s41598-020-74843-x PMC 바로가기 [Article Type] Article
Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein functionBioinformatics Published on 2020-10-162022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory disease addition Affect changed changes in Characteristics COVID-19 Critical detect effort Evolution gene encoding genes encoding Genetic genetic code Genome genomes highlight highlighting Host humans identify in viral independent indicate innate immune system molecular Mutation nonsynonymous Novel coronavirus Perspective positive Positive selection Protein Region Result RNA molecules RNA stability SARS-CoV-2 spike synonymous target Test the SARS-CoV-2 genome Transcription translation unique viral life cycle [DOI] 10.7717/peerj.10234 PMC 바로가기 [Article Type] Bioinformatics
Genomic Diversity and Hotspot Mutations in 30,983 SARS-CoV-2 Genomes: Moving Toward a Universal Vaccine for the “Confined Virus”?Article Published on 2020-10-102022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Analysis analyzed binding Characteristics circulating collected Complete country COVID-19 COVID-19 pandemic distribution Divergence Diversity effective eight ENhance Evolution exonuclease Frequency Genetic genomes genomic diversity GISAID database greater Helicase HIV hotspot hotspot mutations human ACE2 receptor Influenza virus Mutation mutation type Non-synonymous Non-synonymous mutation NSP2 Nsp3 nucleocapsid protein ORF1ab ORF3a ORF8 Perspective polyprotein Prevalence RBD RdRP recurrent mutation SARS-CoV-2 SARS-CoV-2 genome spike Spike protein Spread stability Strains the disease the receptor-binding domain the SARS-CoV-2 the spike protein transmembrane domain understanding Universal Vaccine variant virus viruses Wuhan, China [DOI] 10.3390/pathogens9100829 PMC 바로가기 [Article Type] Article
Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic풍진 바이러스의 과돌연변이된 게놈과 COVID-19 전염병 동안 축적된 SARS-CoV-2 게놈의 돌연변이 스펙트럼 간의 유사성Research Article Published on 2020-10-022022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] accumulated accumulation Analysis APOBEC cytidine deaminase change characteristic COVID-19 pandemic cytidine Cytidine deaminase dataset Each enrichment event genomes genomic RNA human population hypermutated genome hypermutated genomes hypermutation individual isolate lead motif Mutation mutation mechanism mutation mechanisms mutational spectrum new SARS-CoV-2 pathological condition positive predicted preference Propagation reported RNA secondary structure RNA virus rubella rubella vaccine rubella vaccine virus rubella virus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 viruses SARS-CoV2 secondary structure sequenced similarity single base substitution single base substitutions single subject strand genomic RNA subclass substitutions suggested the SARS-CoV-2 virus virus isolate viruses [DOI] 10.1371/journal.pone.0237689 PMC 바로가기 [Article Type] Research Article