Case Report: Co-occurrence of Myocarditis and Thrombotic Microangiopathy Limited to the Heart in a COVID-19 PatientCardiovascular Medicine Published on 2021-07-292022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Analysis anticoagulation Capillaries Combination COVID-19 death described died Diffuse alveolar damage disease etiology feature female healthy heart inflammatory reaction initial Limited Lungs microangiopathy Microthrombosis myocarditis myocarditis acute and fulminant other organs Patient positive prevalent Prophylactic required risk stratification SARS-CoV-2 Symptoms the patient Thromboinflammation Thromboprophylaxis thrombotic Thrombus [DOI] 10.3389/fcvm.2021.695010 PMC 바로가기 [Article Type] Cardiovascular Medicine
Kinetic Multi-omic Analysis of Responses to SARS-CoV-2 Infection in a Model of Severe COVID-19중증 COVID-19 모델에서 SARS-CoV-2 감염에 대한 반응의 동역학적 다중 오믹 분석Pathogenesis and Immunity Published on 2021-07-282022-09-10 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] absence active viral infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar animal model animal models approach caused changes in chemokines coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 develop disease effort evaluated Extrapulmonary gene transcription hamster heart host response host responses human disease human isolates of SARS-CoV-2 immune in vivo increase in Infection innate immune response interferon interferon-stimulated gene isolate kidney kidneys kinetic kinetic analysis lack Model Monocytes Multiorgan neutrophil pandemic Pathogenesis pathology peaked phosphoproteome Phosphoproteomics Pneumonia protein expression proteome proteomics pulmonary disease respiratory response RNA-Seq SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 severe SARS severe SARS-CoV-2 These data to define Transcription Transcriptome transcriptome changes type I Viral viral infection [DOI] 10.1128/JVI.01010-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 PatientsCOVID-19 환자의 부검에서 SARS-CoV-2의 다중 전신 세포 친화성Article Published on 2021-07-272022-09-11 Journal: Cells [Category] SARS, 치료기술, [키워드] ACE2 adrenal gland alteration analyzed assigned Autopsies Autopsy bowel Cell Chain Reaction correlation COVID-19 COVID-19 autopsy sample electron microscopy endothelial cells epithelial epithelial cell epithelial cells expressing fatal COVID-19 FFPE formalin formalin-fixed paraffin-embedded formalin-fixed paraffin-embedded (FFPE) tissue heart histology histopathological immunohistochemistry In situ hybridization Infection kidney liver lung lymph nodes major organs Microscopy organ systems organs oropharynx paraffin polymerase chain polymerase chain reaction Post-mortem Prostate Replication respiratory respiratory tract RNA salivary glands SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 RNA shown Skeletal muscle skin the SARS-CoV-2 Thyroid TMPRSS2 tonsils Trachea transmission electron microscopy tropism tropism of SARS-CoV-2 Viral Viral detection Viral protein Viral RNA virus particle virus particles [DOI] 10.3390/cells10081900 PMC 바로가기 [Article Type] Article
Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: A cohort study in UK Biobank더 짧은 백혈구 텔로미어 길이는 부정적인 COVID-19 결과와 관련이 있습니다: UK Biobank의 코호트 연구Research Paper Published on 2021-07-232022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 95% CI adjusted age Analysis association Biological Biotechnology Causality cohort study collider bias Community Composite conducted coronavirus coronavirus disease Coronavirus disease-19 Council COVID-19 Critical care defined determine Ethnicity evaluate exploratory finding foundation funding genetic variants heart higher risk Hospital admission independent independent of infection with SARS-CoV-2 information leucocyte leukocyte marker Medical Research Council Mortality MR analyses Odds ratio outcome outcomes participant positive randomisation recorded recruited reduced reflect respiratory Respiratory Support risk risk factor Science Sex tested UK biobank UKB with COVID-19 [DOI] 10.1016/j.ebiom.2021.103485 PMC 바로가기 [Article Type] Research Paper
Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infectionSARS-CoV-2 감염의 급성 후유증에서 폐 기능 장애의 면역 섬유증 드라이버Clinical Medicine Published on 2021-07-222022-09-12 Journal: JCI Insight [Category] SARS, 진단, [키워드] acute COVID-19 acute COVID-19 illness affected alveolar American Heart Association Analysis Award Benign carbon monoxide Clinical data correlated cough COVID-19 COVID-19 illness COVID-19 severity declined diffusing diffusing capacity discriminant analysis donation driver Duke Dyspnea element enrolled expiratory Factor Factors fibrosis forced expiratory volume forced vital capacity foundation funding FVC Growth factors heart hematology HGF Hospitalized ICU impaired lung function impairment individual Inflammatory intensive care intensive care unit interquartile range Lcn2 lipocalin-2 lung median Mild multiplex neutrophil neutrophil activation Neutrophils Partial participant PASC performed plasma biomarker plasma sample plasma samples profile prognostic Program prospective cohort study Pulmonary function Pulmonary function tests Pulmonology recovering from COVID-19 respiratory symptom respiratory symptoms SARS-COV-2 infection severity Signaling significantly higher Subjective Symptom Symptoms targets therapeutic university validation cohort vital capacity Volume with COVID-19 Yale University [DOI] 10.1172/jci.insight.148476 PMC 바로가기 [Article Type] Clinical Medicine
SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney시리아 햄스터 모델의 SARS-COV-2 감염은 심장과 신장을 포함한 호흡기 및 비-자극 조직 모두에서 I 형 INTERFERON DYSREGUM뿐만 아니라 염증을 유발합니다.Research Article Published on 2021-07-152022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, SARS, [키워드] (coronavirus disease 2019 acute respiratory syndrome Affect affecting antiviral cytokine antiviral cytokines antiviral response captures cardiovascular system cause caused clinical symptom coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines damage disease dysregulation evaluate Evidence evidence of examination extrapulmonary tissue hamsters heart host response host responses IL-1beta IL-6 immune host response immune responses indicated Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibited interferon interferons investigated kidney kidneys liver microthrombi multiorgan disease myocarditis neurological system non-respiratory tissue occur organ system organ systems PASC people with COVID-19 prolonged disease regulated required respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity significant increases in Symptom Therapeutics TNF tubular inflammation type I interferon type I interferons type II interferon type II interferons upregulation Urinary tract Viral viral infection with infection [DOI] 10.1371/journal.ppat.1009705 PMC 바로가기 [Article Type] Research Article
Relation of prior statin and anti-hypertensive use to severity of disease among patients hospitalized with COVID-19: Findings from the American Heart Association’s COVID-19 Cardiovascular Disease RegistryResearch Article Published on 2021-07-152022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] 95% CI adjusted odds ratio Admission analyses Anti-inflammatory association cardiovascular coronavirus disease COVID-19 CVD death demographic characteristics discharge enrolled evaluate finding heart hospital Hospitalization hypertension immunomodulatory effect indicated individual Logistic regression Medical conditions medication observation occurred organ dysfunction outcome outcomes Outpatient Patient patients hospitalized Population reduce reduced risk reduction in registry relation risk severe inflammation severity Severity of disease statin statistically significant subject Support therapy Treatment used data with COVID-19 [DOI] 10.1371/journal.pone.0254635 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Infection and Emery-Dreifuss Syndrome in a Young Patient with a Family History of Dilated Cardiomyopathy확장성 심근병증의 가족력이 있는 젊은 환자의 SARS-CoV-2 감염 및 Emery-Dreifuss 증후군Case Reports Published on 2021-07-142022-09-10 Journal: Genes [Category] SARS, 변종, 치료기술, [키워드] Affect anamnesis antihypertensive medication Arm ARMS Arterial hypertension Cardiac pathology cardiac troponin Cardiac troponin I cardiological Cardiology Cardiology Department Cardiomyopathy clinical manifestations creatine creatine kinase Department described diagnosed Diagnosis dilated cardiomyopathy discharge disorder dynamic ECGs electrocardiogram Electrocardiograms electrocardiographic Emery–Dreifuss syndrome extension family genetic disease genetic tests heart Heart transplantation heel strike heterozygous high-sensitive cardiac troponin I history Hospitalization Hospitalized hypertension ICD Implantable cardioverter-defibrillator Infectious disease initiated limitation LMNA medical history Mild MRI muscular muscular dystrophy Musculoskeletal musculoskeletal system Mutation myocarditis N-terminal NEUROLOGY NT-proBNP Numerous obesity past Patient peptide performed placement SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection stage 2 suspicion Tachycardia the patient transferred Treatment troponin I variant ventricular ventricular extrasystoles ventricular tachycardia Viral viral myocarditis virus infection walking was performed [DOI] 10.3390/genes12071070 PMC 바로가기 [Article Type] Case Reports
Vital Signs During the COVID-19 Outbreak: A Retrospective Analysis of 19,960 Participants in Wuhan and Four Nearby Capital Cities in ChinaCOVID-19 발병 중 활력 징후: 중국 우한 및 인근 4개 수도에서 19,960명의 참가자에 대한 회고 분석Original Research Published on 2021-07-132022-09-12 Journal: Global Heart [Category] SARS, 진단, [키워드] 95% confidence interval age Anxiety association bpm Capital China Chinese Chongqing city clinical collected Combination COVID-19 COVID-19 outbreak Daily defined Depression dropped Guangzhou heart implication lockdown men mental health MONITOR Nearby oxygen saturation participant Participants physical physical activity reduced Registered registry regression analysis scale selected SIGN Sleep sleep quality Trial Vital vital sign website Wuhan [DOI] 10.5334/gh.913 PMC 바로가기 [Article Type] Original Research
The SARS-CoV-2/Receptor Axis in Heart and Blood Vessels: A Crisp Update on COVID-19 Disease with Cardiovascular Complications심장 및 혈관의 SARS-COV-2/수용체 축 : 심혈관 합병증을 가진 COVID-19 질병에 대한 선명한 업데이트Review Published on 2021-07-122022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 receptor ACE2 receptors Activation association attribute attributes axis binding Blood blood vessel blood vessels bradykinin cardiovascular cardiovascular complication cardiovascular complications cardiovascular disease chronic condition chronic conditions complement Complication components COVID-19 COVID-19 disease Defense described detrimental disease dysfunction Effect Effects endothelial Endothelial dysfunction expression pattern function glycocalyx Health Organization heart Host host defense immune cell response immune cell responses mechanism organ pandemic Patient patient with COVID-19 Platelets potential molecular provide receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus the patient thrombosis vascular leakage vessel vessels WHO World Health Organization [DOI] 10.3390/v13071346 PMC 바로가기 [Article Type] Review