The New Status of Parasitic Diseases in the COVID-19 Pandemic—Risk Factors or Protective Agents?Review Published on 2021-06-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] addition Affect affected available data coronavirus Course COVID-19 COVID-19 infection COVID-19 pandemic diagnose Diagnosis disease Diseases disorders Endemic ENhance evaluated examined Factor highlight immune system Invasion malaria New pandemic parasite parasites parasitosis PROTECT Protective Region risk risk factor SARS-CoV-2 SARS-CoV-2 virus Schistosomiasis selected Severe infection similarity status suggested Symptom with COVID-19 [DOI] 10.3390/jcm10112533 PMC 바로가기 [Article Type] Review
SARS-CoV-2-Host Chimeric RNA-Sequencing Reads Do Not Necessarily Arise From Virus Integration Into the Host DNAMicrobiology Published on 2021-06-022022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome chimeric coronavirus DNA DNA viruses Evidence examined exonic expressed Frequency Host host DNA host genes Human genome human host infected cell integration Intronic Invasion involved mitochondrial nuclear DNA observation Read retroelements reverse transcription RNA RNA virus RNA-Seq RNA-seq data RNA-seq library RNA-sequencing SARS-CoV-2 SARS-CoV-2 RNA sequence suggested transcribed Transcription transfected cell unlikely [DOI] 10.3389/fmicb.2021.676693 PMC 바로가기 [Article Type] Microbiology
Cytokine Overproduction and Immune System Dysregulation in alloHSCT and COVID-19 PatientsImmunology Published on 2021-06-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptive affected age Allogeneic alloHSCT immunology analyzed approach Cell co-morbidities collected data Comorbidities Course COVID-19 COVID-19 immunology COVID-19 patient COVID-19 patients cytokine cytokine overproduction cytokine production Cytokine release syndrome Cytopathic effect damaged DAMP Deleterious deteriorate disease event expression facilitated Factor Genes Genetic hallmark highlighting HLADR homeostasis Host immune system Immunity immunogenetic profiling Increases Inflammatory cytokines inflammatory process Interaction intracellular signaling Invasion laboratory data Malnutrition modify molecular monocyte monocytic-marrow derived suppressor cells over-production of cytokine overproduction pathogenicity pathway Patient patients pro-inflammatory cytokines receptors regimen released respond sequence severity Signal transduction similarity spreads stimulate System TCR beta repertoire tissue Transcription turn vicious cycle virus virus infection [DOI] 10.3389/fimmu.2021.658896 PMC 바로가기 [Article Type] Immunology
Spike in Rhino-Orbital-Cerebral Mucormycosis Cases Presenting to a Tertiary Care Center During the COVID-19 PandemicMedicine Published on 2021-05-282022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome analyzed Care center Characteristics Comorbidities coronavirus coronavirus disease CoV COVID-19 COVID-19 pandemic criteria detect determine Diabetes Mellitus Diagnosis eight explain First wave Hematological malignancy increase in interval Invasion Invasive fungal infection much higher Mucormycosis pandemic positive positive result Positive test preliminary report presenting radiological reported reverse transcription PCR Rhino-orbital-cerebral mucormycosis RT-PCR SARS-CoV-2 spike Tertiary was used [DOI] 10.3389/fmed.2021.645270 PMC 바로가기 [Article Type] Medicine
Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites적혈구 CD55는 말라리아 원충 플라스모디움 팔시파룸의 내부화를 매개한다.Article Published on 2021-05-242024-08-08 Journal: eLife [Category] 말라리아, [키워드] erythrocytes Invasion malaria P. falciparum [DOI] 10.7554/eLife.61516 PMC 바로가기
Investigation of the invasion mechanism mediated by the outer membrane protein PagN of Salmonella Typhimurium살모넬라 타이피무리움의 외막 단백질 PagN에 의해 매개되는 침입 메커니즘 조사Research Published on 2021-05-212024-07-29 Journal: BMC Microbiology [Category] 살모넬라증, [키워드] Actin Invasion Outer membrane protein PagN Salmonella Zipper-like entry pathway [DOI] 10.1186/s12866-021-02187-1 PMC 바로가기 [Article Type] Research
Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patientsCOVID-19 환자에서 TMPRSS2 p.Val160Met 유전자 변이에 대한 초기 연구Primary Research Published on 2021-05-172022-09-10 Journal: Human Genomics [Category] SARS, 변종, 치료기술, [키워드] Affect analysed association asymptomatic infection C allele cause Cell clinical manifestation coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-19 severity Ct value death diagnostic disease disease severity field field hospital General Hospital genetic variability Genetic variant genotyped Health health problem hospitalised Host host cell host cells Indonesia Infection Interaction Invasion investigated involved mortality rate nucleic acid nucleic acid amplification observé outcome Patient patients with COVID-19 polymorphism protease Receptor binding receptor complex Result SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2 virus Serine serine 2 severe COVID-19 severe pneumonia severity supplementary material systemic inflammatory TaqMan the disease the SARS-CoV-2 thought TMPRSS2 transmembrane transmembrane protease serine 2 Viral Viral load virus infection [DOI] 10.1186/s40246-021-00330-7 PMC 바로가기 [Article Type] Primary Research
Ultraviolet light-induced collagen degradation inhibits melanoma invasionArticle Published on 2021-05-122022-10-04 Journal: Nature Communications [Category] 변종, [키워드] arising Biomarker Cancer cancer cell Cancer microenvironment cancers Cell Col1a1 collagen contribute death Degradation degrade ECM expressing expression Extracellular matrix fibroblast Gene Expression Human IMPROVE incidence increase inhibit inhibiting Invasion invasive less Local Melanoma MMP1 modify outcome predictor Prognosis reduced reducing restored robust Single Cell survival Ultraviolet radiation [DOI] 10.1038/s41467-021-22953-z PMC 바로가기 [Article Type] Article
Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyteOriginal Investigation Published on 2021-05-072022-10-31 Journal: Cardiovascular Diabetology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression ACE2 protein ACE2 receptor affecting alterations Autopsies Autopsy binding cardiomyocyte cellular entry coronavirus disease COVID-19 COVID-19 infection Deceased diabete diabetes diagnosed domain Effect evaluate evaluate the effect evaluated expression Glucose glycosylated glycosylated forms hACE2 heart Hospitalized human ACE2 in vitro include Infection Invasion investigated Italy lysine mechanism Modification monomeric myocardial damage objective oligomerization Patient patients patients with diabete protease Protein rationale residue SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV2 Serine spike supplementary material susceptibility tissue TMPRSS2 TMPRSS2 protein Total transmembrane upregulation viral invasion was performed [DOI] 10.1186/s12933-021-01286-7 PMC 바로가기 [Article Type] Original Investigation
Phytochemical Moieties From Indian Traditional Medicine for Targeting Dual Hotspots on SARS-CoV-2 Spike Protein: An Integrative in-silico ApproachMedicine Published on 2021-05-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 binding ACE2 receptor Anti-viral antivirals bind binding affinity binding energy binding free energy complex Compound compounds COVID-19 Curcuma docking drug design Drug discovery Dynamics eight glycosylation glycosylation site Host hotspot immunomodulatory impair in silico in-silico Infection Interaction intermolecular interaction Invasion Medicine moiety molecular dynamics phytochemical plant Protein RBD respiratory disorders SARS-CoV-2 SARS-COV-2 infection screened spike Spike protein spike-ACE2 stability subsequent Syzygium targeting the binding affinity these compound Traditional Traditional medicine Treatment Virologist [DOI] 10.3389/fmed.2021.672629 PMC 바로가기 [Article Type] Medicine