Endogenously Produced SARS-CoV-2 Specific IgG Antibodies May Have a Limited Impact on Clearing Nasal Shedding of Virus during Primary Infection in Humans내인적으로 생성된 SARS-CoV-2 특이적 IgG 항체는 인간의 1차 감염 동안 바이러스의 비강 배출 제거에 제한적인 영향을 미칠 수 있음Article Published on 2021-03-202022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] antibody antibody kinetics antigenic antigenic stimulation binding characterized Clearing Clinical severity ENhance Human IgG IgG and IgM IgG antibodies IgG level IgG levels IgM antibodies Immunity Impact Infection isotype Limited mathematical mathematical model Mathematical models Mitigation nasal passage nasal passages natural infection neutralization no effect occur Primary infection production rate resulting SARS-CoV-2 SARS-CoV-2 viral severe disease severity shedding Specific specific IgG antibodies specific IgG antibody specific neutralizing antibodies specific neutralizing antibody symptom onset therapeutic purposes Trigger triggers vaccination Viral viral clearance viral dynamics virus while [DOI] 10.3390/v13030516 PMC 바로가기 [Article Type] Article
Exaptation of Retroviral Syncytin for Development of Syncytialized Placenta, Its Limited Homology to the SARS-CoV-2 Spike Protein and Arguments against Disturbing Narrative in the Context of COVID-19 VaccinationReview Published on 2021-03-192022-10-28 Journal: Biology [Category] COVID-19, [키워드] Affect argument Cell cells coded Context COVID-19 COVID-19 vaccine development Env Evolution Exaptation exogenous retroviruses facilitate facilitated function fused generate glycoprotein Health host cell host cell membrane Human immune response Impact Interaction Limited mammalian mechanism mother narrative Newborn Placenta Pregnancy Protein required retroviral retrovirus S protein SARS-CoV-2 SARS-CoV-2 vaccine sequence similarity similarity simple spike Spike protein syncytin the SARS-CoV-2 unlikely uterine viral envelope virus [DOI] 10.3390/biology10030238 PMC 바로가기 [Article Type] Review
Countries with delayed COVID-19 introduction – characteristics, drivers, gaps, and opportunitiesResearch Published on 2021-03-172022-11-01 Journal: Globalization and Health [Category] COVID-19, [키워드] activity Analysis analyzed association Border control measures Characteristics collected contribute contributed country COVID-19 COVID-19 testing detect disease disease detection Drivers Factor geographic location global health identify IMPROVE Influenza information International Isolation Limited measure Measures MONITOR MOST National organization outbreak Outbreaks pandemic preparedness Prevent reported respond Result spread of COVID-19 spread to supplementary material Surveillance Temporal Travel WHO [DOI] 10.1186/s12992-021-00678-4 PMC 바로가기 [Article Type] Research
Initial Insights Into the Genetic Epidemiology of SARS-CoV-2 Isolates From Kerala Suggest Local Spread From Limited IntroductionsGenetics Published on 2021-03-172022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] A2a clade Affect affecting amplicon-based sequencing Analysis China Coronavirus disease 2019 country COVID-19 COVID-19 case COVIDSeq COVIDSeq protocol Efficacy Epidemiology FIVE functional variant Genetic Genetic epidemiology haplotype analysis India individuals insight isolate Kerala knowledge Limited Local mapped outbreak Patient primer binding site rapid increase RT-PCR S gene SARS-CoV-2 sequenced single-nucleotide Spread variant variants virus [DOI] 10.3389/fgene.2021.630542 PMC 바로가기 [Article Type] Genetics
Seroconversion stages COVID19 into distinct pathophysiological states혈청전환은 COVID19를 별개의 병태생리학적 상태로 단계화합니다.Research Article Published on 2021-03-162022-09-10 Journal: eLife [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] Activation Alpha Analysis antibodies Antibody titer Antibody titers B cell subsets Biomarker biosignature clinical trial complement Complement activation COVID19 COVID19 patient cross-sectional Cytokines D-dimer Depletion driving end-organ damage endothelial damage Hematopoiesis heterogeneous heterogenous Hospitalized Human hyperinflammation Hypoalbuminemia IFN Increases increases in interferons knowledge lack ligands Limited Lymphocytes marker molecular mechanism molecular mechanisms Neutrophils NK cells pathophysiological Patient Platelets populations SARS Seroconversion Stage T cell T cells therapeutic intervention thrombotic thrombotic microangiopathy [DOI] 10.7554/eLife.65508 PMC 바로가기 [Article Type] Research Article
Vulnerability and Burden of All-Cause Mortality Associated with Particulate Air Pollution during COVID-19 Pandemic: A Nationwide Observed Study in ItalyArticle Published on 2021-03-152022-10-28 Journal: Toxics [Category] COVID-19, [키워드] age and gender all-cause mortality association burden collected Concentration COVID-19 COVID-19 pandemic death decrease Effect Evidence fraction Health increase in increased mortality Italian Italy Limited much higher Observed pandemic pandemic of COVID-19 Particulate Particulate matter Pollution stratified vulnerability was used [DOI] 10.3390/toxics9030056 PMC 바로가기 [Article Type] Article
Evaluation of the Current Therapeutic Approaches for COVID-19: A Systematic Review and a Meta-analysisPharmacology Published on 2021-03-152022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antibiotics Antiviral Antiviral agents antivirals applied Arbidol clinical feature Clinical improvement Clinical treatment Combination Corticosteroid COVID-19 COVID-19 mortality COVID-19 patients COVID-19 severity COVID-19 therapeutics COVID-19 treatment current death Dexamethasone Disease progression effective Efficacy and safety higher risk Hospitalization Hydroxychloroquine incidence involved Limited management Meta-analysis Mortality not significant objective outcome performed prevalent raised reduce reduced reducing Remdesivir review ribavirin Safe severe adverse events significantly SMD standardized mean difference treating COVID-19 Treatment treatments of COVID-19 use of corticosteroid use of hydroxychloroquine [DOI] 10.3389/fphar.2021.607408 PMC 바로가기 [Article Type] Pharmacology
“People Associate Us with Movement so It’s an Awesome Opportunity”: Perspectives from Physiotherapists on Promoting Physical Activity, Exercise and SportArticle Published on 2021-03-142022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] activity Ageing approach Associate build children Clinical practice coded coding Community conducted connection Critical disability ENhance exercise FIVE group Health Health promotion implementation information Insufficient iterative knowledge lack Limited movement Older physical activity Physical therapy Physiotherapist physiotherapists Physiotherapy professional promote Promoting public health Research researcher returned sport Strategy Support transcript Treatment [DOI] 10.3390/ijerph18062963 PMC 바로가기 [Article Type] Article
Inactivation of Human Coronavirus by FATHHOME’s Dry Sanitizer Device: Rapid and Eco-Friendly Ozone-Based Disinfection of SARS-CoV-2Article Published on 2021-03-142022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ambient coronavirus COVID-19 death Detection limit Disinfection dose Dry effective Efficacy evaluated expected faster FATHHOME genetic model HCoV-OC43 Host human coronavirus inactivated inactivation increase in Limited morbidity and mortality pandemic Personal protective equipment porous PPE pre-existing immunity Rapid reduced reduction reported SARS-CoV-2 SARS-CoV-2 variant Spread tested Transmissibility unique virucidal virus virus decontamination Wuhan, China [DOI] 10.3390/pathogens10030339 PMC 바로가기 [Article Type] Article
Longitudinal antibody repertoire in “mild” versus “severe” COVID-19 patients reveals immune markers associated with disease severity and resolutionComparative Study Published on 2021-03-052022-10-04 Journal: Science Advances [Category] SARS, 바이오마커, 진단, [키워드] acute COVID-19 Affinity maturation antibody affinity Antibody binding antibody marker antibody repertoire antigenic clinical disease coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated disease severity effective epitope Evolution of SARS-CoV-2 faster fusion peptide IgA IgG immune marker immunodominant Immunoglobulin increase in knowledge Limited longitudinal maturation Mild Patient patients with COVID-19 prefusion RBD Receptor binding domain reveal SARS-COV-2 infection SARS-CoV-2 spike sequence severe COVID-19 [DOI] 10.1126/sciadv.abf2467 PMC 바로가기 [Article Type] Comparative Study