lung damage – Page 19 – Communicable Diseases Research

Can Stem Cells Beat COVID-19: Advancing Stem Cells and Extracellular Vesicles Toward Mainstream Medicine for Lung Injuries Associated With SARS-CoV-2 Infections

Bioengineering and Biotechnology

Published on 2020-05-262022-10-31
Journal: Frontiers in Bioengineering and Biotechnology
[Category] COVID-19,

Anticipating the impact of the COVID-19 pandemic on TB patients and TB control programmes

Review

Published on 2020-05-232022-10-28
Journal: Annals of Clinical Microbiology and Antimicrobials
[Category] COVID-19, MERS, SARS,

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

코로나19 환자를 위한 지방유래 중간엽줄기세포의 임상적 사용 근거

Review

Published on 2020-05-182022-09-10
Journal: Journal of Translational Medicine
[Category] MERS, SARS, 비임상,

[키워드] acute respiratory distress acute respiratory distress syndrome administration alveolar fluid clearance animal model animal models antimicrobial ARDS ASC benefit breath capital city Cell China Clinical studies clinical study Clinical use Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 outbreak COVID-19 patient Critical demonstrated distress edema effective Ex vivo Fever global pandemic globe greater Health Organization healthcare high mortality rate hospital resources human clinical trials human lung hypoxia illness immune response immune responses immunomodulatory activities in some in vivo Inflammation inhibit intravenous Intravenous administration intravenous route lead Local lung lung damage Lungs majority Mesenchymal stem cells molecules morbidity morbidity and mortality MSC MSCs multi-organ failure Multiple Novel coronavirus older patients Pain Patient patient mortality per day Pneumonia pulmonary disease Pulmonary edema Pulmonary function rationale reduce reduced respiratory respiratory distress respiratory symptoms risk Safe SARS-CoV-2 SARS-COV-2 infection severe disease Severe respiratory distress stem cell stem cells syndrome therapeutic option therapy Travel Treatment treatment of COVID-19 Viral viral outbreak viral respiratory with COVID-19 World Health Organization Wuhan
[DOI] 10.1186/s12967-020-02380-2 PMC 바로가기 [Article Type] Review

Cytokine storm intervention in the early stages of COVID-19 pneumonia

Article

Published on 2020-04-252023-07-01
Journal: Cytokine & growth factor reviews
[Category] SARS,

[키워드] COVID-19 Cytokine storm Inflammation lung damage SARS-CoV2
[DOI] 10.1016/j.cytogfr.2020.04.002 PMC 바로가기 [Article Type] Article

A potential protective role of losartan against coronavirus-induced lung damage

Letter to the Editor

Published on 2020-03-172022-10-30
Journal: Infection Control and Hospital Epidemiology
[Category] COVID-19, SARS,

[키워드] losartan lung damage protective role
[DOI] 10.1017/ice.2020.80 PMC 바로가기 [Article Type] Letter to the Editor

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4 -transgenic mice infected with MERS-CoV

Article

Published on 2018-04-242022-10-31
Journal: Emerging Microbes & Infections
[Category] Coronavirus,

[키워드] accompanied activated Activation acute lung injury alleviate antibody treatment Apoptosis blockade C5a cause Cell cells chemokines complement Concentration contribute cytokine dysregulated elevated greater hDPP4 high mortality highly pathogenic Host immune response Inflammatory responses Intervention investigated less lung lung damage lung tissues manifested MERS-CoV MERS-CoV infection mice Middle East observation outcome Pathogenesis promote receptor reduced Respiratory failure respiratory syndrome coronavirus secretion sera spleen spleen tissue T cell tissue damage treated Treatment triggered viral infection viral replication
[DOI] 10.1038/s41426-018-0063-8 PMC 바로가기 [Article Type] Article

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

Research Article

Published on 2014-08-142022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] activate activating Activation acute respiratory syndrome addition administration analyses assays caused Cell cellular complementary confocal microscopy coronavirus cytoplasm decrease decreased expression Deleterious demonstrated determinant domain E protein Elimination envelope Epidemic exacerbated functional genetics highlight immune response immunopathology in vivo increase in induce infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibitor interact Interaction interactions involved lung lung damage MAPK mice modulating Mortality motif nucleus overexpression parental pathway potential therapeutic target Protein Proteins proteomic recombinant reduce reduction in respiratory SARS-CoV SARS-CoV E SARS-CoV infected cells SARS-CoV infection siRNA survival triggered triggering virulence virus virus virus attenuation was reduced yeast
[DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

Research Article

Published on 2014-05-012022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] absence accompanied Activation activity acute respiratory distress Affect airway Amino acid ARDS assays ATPase attenuate Cell channel compensatory mutation complexes Concentration correlated Critical cytokine cytosolic death Deletion demonstrated died disease Diseases displaying E gene E protein edema ENCODE envelope eventually death experiment fitness highly pathogenic IL-1β IL-6 in viral induce inducer Infection infections Inflammasome inflammasome activation Inflammatory cytokine Inflammatory response innate immune system Interaction involved Ion ion homeostasis less Level lost weight lung lung damage lung epithelia macromolecular maturation mechanism mice multifunctional protein mutant mutant viruses Mutation outcome Pathogenesis pathology produced progression promote Protein pulmonary damage reduced reducing required respiratory restored SARS-CoV SARS-CoV E SARS-CoV infection sequence severe hypoxemia significantly suppressed survived syndrome therapy this system TNF translated transmembrane protein Transport viral infection virulence virus virus virus growth virus pathogenesis virus production wild-type
[DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article

Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses

Research Article

Published on 2009-09-232022-10-28
Journal: PLoS ONE
[Category] Coronavirus,

[키워드] accelerate accelerated antibody production Antigen appear Asymptomatic B cell CAGE cause CD4+ T cell clearance described destruction develop different disparate dose ENhance finding functional Host immune response immune response immune responses Immune-mediated Immunity independent Infection Inflammation influenza viruses inherent less limit lung lung damage Lymphoid tissue mechanisms morbidity nanoparticle novel virus pathogen Primary infection primary viral infection protection protective immune response Protein pulmonary viral recruitment Replication respiratory respiratory virus Safe SARS-coronavirus significant decrease significantly significantly increased specificity survival Treatment Vaccination strategies viral antigens viral clearance virus
[DOI] 10.1371/journal.pone.0007142 PMC 바로가기 [Article Type] Research Article

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

Research Article

Published on 2006-07-042022-10-29
Journal: PLoS Medicine
[Category] Coronavirus,

[키워드] 2003 acute respiratory syndrome Administered affected against SARS-CoV Alter Amino acid anti-SARS-CoV antibody antibody antibody concentration Antigen antigens approach arising Bacteria binding blocked Blood breadth carried caused center China close contact close person-to-person contact Combination complementary Concentration Control convalescent SARS patient coronavirus Coverage CR3014 CR3022 died different disease disease severity dose Effect effective Epidemic Epidemics epitope escape experiment feasible ferret ferrets finding generate glycoprotein Guangdong Health healthy Hong Kong Human human cell human cells human macrophage Human monoclonal antibody humans immune Immune escape immunization immunize in vitro individual effects Infected infecting Infection infectious Infectious disease information interact Interaction International killing Laboratory less limit lung damage Lung pathology mAb mAbs measure monoclonal monoclonal antibody Mutation neutralization neutralized NO organism Patient pharyngeal Prevent prevented prevention producing Prophylaxis provided quarantine recognize recognizing reduce reduction repeated replicated required Research researcher residue responsible SARS epidemic SARS-CoV SARS-CoV infection screened shown sick Spread strain suppress synergistic synergistic fashion synergy tested the disease the receptor-binding domain Travel treat variant variants viral escape viral spread virus virus Virus neutralization virus strain virus-neutralizing viruses website Wikipedia World Health Organization
[DOI] 10.1371/journal.pmed.0030237 PMC 바로가기 [Article Type] Research Article