A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic CoronavirusesAntiviral Agents Published on 2021-11-222022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] active against activity acute respiratory syndrome Antiviral antiviral activity Antiviral agents broad-spectrum antiviral bronchial epithelial cells coronavirus CoV-229E COVID-19 CoVs demonstrated described highly active Including inhibit inhibitor mechanism of action MERS-CoV Microscopy Middle East natural natural antiviral natural product outbreak product reduced Replication respiratory syndrome coronavirus SARS-CoV-2 shown therapy viral membrane viral particle virucidal virus virus entry [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic CoronavirusesAntiviral Agents Published on 2021-11-222022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] active against activity acute respiratory syndrome Antiviral antiviral activity Antiviral agents broad-spectrum antiviral bronchial epithelial cells coronavirus CoV-229E COVID-19 CoVs demonstrated described highly active Including inhibit inhibitor mechanism of action MERS-CoV Microscopy Middle East natural natural antiviral natural product outbreak product reduced Replication respiratory syndrome coronavirus SARS-CoV-2 shown therapy viral membrane viral particle virucidal virus virus entry [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses고도로 병원성 코로나 바이러스를 포함하여 포집 바이러스에 대한 광범위한 항 바이러스 활성을 갖는 광 활성화 가능한 천연 제품Antiviral Agents Published on 2021-11-222022-09-10 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] active against activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity Antiviral agents broad-spectrum antiviral broad-spectrum antivirals bronchial epithelial cells Cell fusion coronavirus CoV replication CoV-229E COVID-19 COVID-19 therapy CoVs Cryoelectron microscopy demonstrated described Disinfection epithelial cells highly active human CoV Including inhibit inhibitor mechanism of action MERS MERS-CoV Microscopy Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus natural natural antiviral natural product outbreak primary human bronchial epithelial cells product reduced Replication respiratory respiratory syndrome coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown therapy Viral viral membrane viral particle virucidal virus virus entry viruses [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra LeoneansSierra Leoneans의 Covid-199 혈액 샘플에서 SARS-COV-2 및 MERS-COV에 대한 교차 반응성 항체Article Published on 2021-11-212022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age American Americans antibodies binding antibody binding Blood donors blood sample Blood samples collected Contact contribute coronavirus Coronavirus-2 country COVID-19 COVID-19 case COVID-19 caseloads and deaths cross-protective immunity cross-react death Ebola enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes had more healthy blood donor healthy blood donors humans induce infect Lassa fever MERS-CoV MERS-CoV pseudovirus middle Middle Eastern respiratory syndrome coronavirus neutralized Neutralizing antibodies neutralizing antibody not differ pandemic pre-existing immunity pre-existing immunity to coronaviruses presence of antibody Protein pseudovirus neutralizing antibodies recombinant antigens reduced Region reported Reporting respiratory respiratory syndrome coronavirus response Result Sample SARS-CoV SARS-CoV-2 SARS-CoV-2 pseudovirus seasonal coronavirus seasonal coronaviruses Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Sex sub-Saharan Africa subject survivor The United States United States were assessed [DOI] 10.3390/v13112325 PMC 바로가기 [Article Type] Article
Waning antibodies from inactivated SARS-CoV-2 vaccination offer protection against infection without antibody-enhanced immunopathology in rhesus macaque pneumonia models비활성화된 SARS-CoV-2 백신 접종으로 인한 항체 약화는 붉은털 원숭이 폐렴 모델에서 항체 강화 면역병리학 없이 감염에 대한 보호를 제공합니다Letter Published on 2021-11-212022-09-10 Journal: Emerging Microbes & Infections [Category] Coronavirus, SARS, 진단, 치료기술, [키워드] absence acute phase acute respiratory syndrome acute respiratory syndrome coronavirus ADE alveolar anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody Antibody Response Antibody-dependent enhancement bronchioles Bronchoalveolar lavage Bronchoalveolar lavage fluid Cell cellular immunity clinical trial control group coronavirus Coronaviruses elevated epithelial Evidence evidence of humans IL-33 IL-8 immunology immunopathology inactivated Inactivated Vaccines Infection initial MCP-1 MERS-CoV Middle East Middle East respiratory syndrome Coronavirus Mild mild to moderate moderate Mucus murine neutralizing antibody NHP no evidence of observation offer passive transfer Pneumonia polyclonal antibodies polyclonal antibody postvaccination preclinical studies preclinical study pulmonary immunopathology reported respiratory Respiratory disease respiratory diseases respiratory syndrome coronavirus rhesus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus subneutralizing antibodies supported transfer Typical vaccination Vaccine virus virus infection [DOI] 10.1080/22221751.2021.2002670 PMC 바로가기 [Article Type] Letter
Kinetics of antibody response in critically ill patients with Middle East respiratory syndrome and association with mortality and viral clearanceArticle Published on 2021-11-192022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] 95% CI Admission admitted to ICU antibody Antibody Response Antigen assessment association blood sample clearance coated with collected Corticosteroids Critically ill Critically ill patient Diseases ELISA enzyme-linked immunosorbent failure faster ICU IgG antibody immunology Immunotherapy implication invasive ventilation Kinetics lower mortality median MERS MERS patient MERS-CoV MERS-CoV RNA MERS-CoV S1 Middle East Mortality onset of symptom optical Pathogenesis Patient renal replacement therapy rRT-PCR significantly increased Signs and symptoms SOFA study cohort syndrome vasopressors viral clearance [DOI] 10.1038/s41598-021-01083-y PMC 바로가기 [Article Type] Article
Jumper enables discontinuous transcript assembly in coronaviruses점퍼는 코로나바이러스에서 불연속 전사 조립을 가능하게 합니다.Article Published on 2021-11-182022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] alignment analyses Analysis assembly canonical classical conditions coronavirus develop discontinuous transcription drug response eukaryote eukaryotes expressed expression Gene Expression Genome informatics identify JUMPER likelihood MERS-CoV Nidovirale Nidovirales outperform predict produced reveal RNA polymerase RNA splicing RNA-dependent RNA polymerase SARS-CoV-1 SARS-CoV-2 Software subsequent supported transcript transcriptional change Transcriptional changes Transcriptome transcriptomes transcripts Treatment Viral Viral RNA viral RNA-dependent RNA polymerase virus viruses [DOI] 10.1038/s41467-021-26944-y PMC 바로가기 [Article Type] Article
Bibliometric Analysis and Systematic Review of Global Coronavirus Research Trends Before COVID-19: Prospects and Implications for COVID-19 ResearchMedicine Published on 2021-11-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Analysis ANOVA articles bibliometric analysis Clinical diagnosis Cluster Collection conducted contributed contribution coronavirus Coronaviruses CoV COVID-19 database Diagnosis Epidemiology Hong Kong infections intestinal journal mechanism MERS-CoV OVID pathology Research Research topics review searched systematic review trajectory Treatment trend university USA Virology Visualization Web of Science were used [DOI] 10.3389/fmed.2021.729138 PMC 바로가기 [Article Type] Medicine
Drug repurposing against SARS-CoV-1, SARS-CoV-2 and MERS-CoVSARS-CoV-1, SARS-CoV-2 및 MERS-CoV에 대한 약물 용도 변경Review Published on 2021-11-102022-09-10 Journal: Future Microbiology [Category] MERS, SARS, 신약개발, 치료제, [키워드] administration amodiaquine Antiviral antiviral activity approval Azithromycin Chloroquine Clinical studies Clofazimine Clofoctol coronavirus COVID-19 COVID-19 pandemic COVID-19 treatment drug drug candidate Drug repurposing drugs Favipiravir health emergency heparin Hydroxychloroquine in silico in vitro in vitro study in vitro testing International Ivermectin Medicine MERS-CoV molecular docking nelfinavir nitazoxanide oral administration reduced SARS-CoV-1 SARS-CoV-2 Toxicity Treatment [DOI] 10.2217/fmb-2021-0019 PMC 바로가기 [Article Type] Review
False-positive HIV in a patient with SARS-CoV-2 infection; a case reportCase Report Published on 2021-11-062022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] antibody antibody cross-reactivity Case report Corona coronavirus COVID-19 COVID-19 patient COVID-19 vaccination cross-reactivity Diagnosis Epstein Barr virus False positive False-positive false-positive result female HIV Human immunodeficiency virus immunoassay Infection influenza vaccination interfere Laboratory MERS-CoV Mild symptom Patient patient with SARS-CoV-2 PCR PCR testing positive problem Protein reported required RNA SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein screening test screening tests Sensitivity and specificity similarity Spike protein Supportive treatment the immunoassay the spike protein Thyroid thyroidectomy turn virus viruses was performed yielding Zika [DOI] 10.1016/j.amsu.2021.103027 PMC 바로가기 [Article Type] Case Report