SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon ResponseArticle Published on 2021-03-022022-10-06 Journal: Cells [Category] SARS, 진단, [키워드] acute respiratory syndrome antiviral drug antiviral immune response antiviral immunity association characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Gene Expression Host IFN IFN signaling induction Influenza virus inhibited Interaction interferon interferon regulatory factor IRF3 lack modulating molecular motif N protein nonstructural protein 1 nuclear translocation nucleocapsid protein pandemic pathogenesis of SARS-CoV-2 Protein response RIG-I RIG-I like receptors SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein suppressed target TBK1 the SARS-CoV-2 TRIM25 type I urgency Zika virus [DOI] 10.3390/cells10030530 PMC 바로가기 [Article Type] Article
A Negative Feedback Model to Explain Regulation of SARS-CoV-2 Replication and TranscriptionGenetics Published on 2021-02-262022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory syndrome caused cleavage site cleaving comprehensive analysis Control coronavirus Coronavirus disease 2019 CoV CoV replication COVID-19 CoVs derivatives drug explain expression level feedback Gene Expression genome sequence genomic RNA hosts influence knowledge mechanism Model molecular basis motif negative Nsp15 persistence proportion Protein regulate regulated Regulation regulation model Replication Result RNA SARS-CoV-2 sgRNA sgRNAs subgenomic RNA Transcription transcription regulatory sequence TRS TRSs turn uridine [DOI] 10.3389/fgene.2021.641445 PMC 바로가기 [Article Type] Genetics
CXCL17 Is a Specific Diagnostic Biomarker for Severe Pandemic Influenza A(H1N1) That Predicts Poor Clinical OutcomeImmunology Published on 2021-02-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, 신종인플루엔자, [키워드] A549 cell Admission Algorithm alveolar analyzed Anti-viral assays Autopsy Cell culture chemokine chemokines chemotactic clinical Cohort cohort of patient coronavirus disease COVID-19 COVID-19 patients CXCL17 died ELISA enrolled enzyme-linked immunosorbent evaluated exhibit expressed expression expression pattern functions Future Hospitalization humans immunohistochemistry incidence Influenza influenza A(H1N1) Ligand lung lung tissue machine-learning Mexico City monocyte-derived macrophage Mortality motif myeloid cells other respiratory infection pandemic Patient patients Peripheral blood Peripheral blood sample Poor poor prognosis post-mortem lung predict processed Prognostic value PTB pulmonary tuberculosis Regression analyses renal required respiratory pathogen respiratory tract SARS-CoV-2 Seasonal influenza serum Serum level Seven Specific specimen the disease Tuberculosis utility virus infection was tested [DOI] 10.3389/fimmu.2021.633297 PMC 바로가기 [Article Type] Immunology
Low compositions of human toll-like receptor 7/8-stimulating RNA motifs in the MERS-CoV, SARS-CoV and SARS-CoV-2 genomes imply a substantial ability to evade human innate immunityBioinformatics Published on 2021-02-242022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] bats comparison computational method coronavirus coronavirus genomes Coronaviruses Defense evade evaluate exhibited Genome genomic genomic RNA hosts Immunostimulating RNA motifs innate immune response innate immune system Innate immunity Logistic regression mammalian MERS-CoV motif pathway positive prediction receptor Result RNA RNAs SARS-CoV SARS-CoV-2 SARS-CoV-2 genome single-stranded RNA virus Single-stranded RNA viruses Surveillance the interferon TLR Toll-like receptor Toll-like receptor 7/8 trimer was used [DOI] 10.7717/peerj.11008 PMC 바로가기 [Article Type] Bioinformatics
Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 PatientsImmunology Published on 2021-02-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Accessibility accompanied Activation Analysis approaches CD4 CD69 CD8 Cell Characteristics chromatin chromatin accessibility Control coronavirus diseases COVID-19 creating Critical element enhancer Epigenetic expressed function Genes HCs healthy HLA class II HLA-DRA HLA-DRB1 HLA-DRB5 immune Immune profile infected with COVID-19 inflammatory genes inflammatory pathways inflammatory state involved key factor landscape less MAPK moderate mononuclear cell motif Necrosis NFKBIA nine Pathogenesis Patient patients with COVID-19 PBMCs performed Peripheral blood PIK3R1 profile profiles promoter proportion Protein provided regions RNA S100A9 SARS-CoV-2 scATAC-seq scRNA-seq ScRNA-seq analysis seq Sequencing signaling pathway significantly Single Cell single-cell T cell T cells T-cell TBX21 Th1 TNF transcriptome profiling transcriptomic upregulated were used [DOI] 10.3389/fimmu.2021.625881 PMC 바로가기 [Article Type] Immunology
Exploring novel and potent cell penetrating peptides in the proteome of SARS-COV-2 using bioinformatics approachesResearch Article Published on 2021-02-192022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] addition analyses approach binding bioinformatics calculated Cancer therapy Cell cell membrane cells cellular coronaviruses family CPP Efficiency evaluated Features herpes simplex highest HIV-1 homing Host HSV-1 immunodeficiency in silico Infection investigated main role mammalian cells membrane molecular weight motif NLS nuclear penetrate Penetrating penetration peptide physicochemical property predicted Probability proteome proteome of virus residue SARS-CoV-2 sequence submitted Toxicity Vaccine virus [DOI] 10.1371/journal.pone.0247396 PMC 바로가기 [Article Type] Research Article
MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2Article Published on 2021-02-182022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] affected bind binding candidate COVID-19 Diseases distribution drug effective Gene Expression H19 human miRNAs in viral Infection inflammatory complications inhibiting leader sequence lncRNA Long long non-coding RNA microRNA motif non-coding RNA Non-coding RNAs nucleotide oligosequences Potential promote promoted pulmonary arterial hypertension Respiratory system RNA SARS-CoV-2 SARS-CoV-2 genome selective sequence Specific spike target target therapy the SARS-CoV-2 genome therapy transcript Vaccine viral genome viral infections Viral RNA viral-induced [DOI] 10.3390/ncrna7010014 PMC 바로가기 [Article Type] Article
The analysis on the human protein domain targets and host-like interacting motifs for the MERS-CoV and SARS-CoV/CoV-2 infers the molecular mimicry of coronavirusResearch Article Published on 2021-02-172022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Analysis biological process biological processe carbon source coronavirus Coronavirus infection develop disease DMI domain effective enrichment expression help highly pathogenic host cells human protein humans information Interaction mapped mechanism Medicine MERS-CoV molecular MOST motif Ontology potassium channel Protein protein domain proteomes Regulation SARS-CoV SARS-CoV-2 T cell epitopes target Therapies Treatment Viral protein virus viruses was performed [DOI] 10.1371/journal.pone.0246901 PMC 바로가기 [Article Type] Research Article
Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genesResearch Paper Published on 2021-02-092022-10-04 Journal: Current Research in Microbial Sciences [Category] 바이오마커, 변종, [키워드] ACE2 amino acid sequence Analysis approach binding activity Biomarker cancer patient caused Cell co-expressed Comorbidity COVID-19 COVID-19 infection CXCL10 cytokine Cytokine storm database disease entry of SARS-CoV-2 enzyme evaluate expression fatality Frequency functional Genetic host cell hub protein immune response involved lung lung adenocarcinoma lung cancer lung cancer patient lung cancer patients lung cell motif Mutation overexpressed pandemic disease PPI network protein sequences receptor protein reported respiratory responsible SARS- CoV-2 SARS-CoV-2 susceptibility susceptible upregulated [DOI] 10.1016/j.crmicr.2021.100022 PMC 바로가기 [Article Type] Research Paper
Uncovering potential host proteins and pathways that may interact with eukaryotic short linear motifs in viral proteins of MERS, SARS and SARS2 coronaviruses that infect humansResearch Article Published on 2021-02-032022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] caused component composed coronavirus coronavirus protein dissemination effective eukaryotic Host host cell host cells host protein Human humans immune evasion Improved in viral infect infecting intracellular protein kinases linear MERS motif Novel coronavirus pandemic pathway potential mechanism potential therapeutic target Protein Proteins provide receptors RNA viruses SARS-CoV-2 SARS2 Spread target transcription factor viral infections viral pathogenesis Viral protein virus replication [DOI] 10.1371/journal.pone.0246150 PMC 바로가기 [Article Type] Research Article