Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
중증 COVID-19에서 SARS-CoV-2 감염에 대한 국소 고유 면역 손상
Article
[키워드] Abstract
Anti-viral
Anti-viral immunity
anti-viral response
anti-viral responses
antiviral response
AZGP1
Cell
Cell loss
cell tropism
cells
changes in
ciliated
ciliated cell
correlates of immunity
COVID-19
detrimental
epithelia
epithelial
epithelial cell
epithelial cells
epithelial immunity
expansion
Express
Genes
goblet
healthy
heterogenous
Human
identify
Immunity
Impaired
individual
induce
infected individuals
Infection
influence
interferon
intrinsic
KRT13
leads
Local
Mild
Moderate COVID-19
nasal
nasal mucosa
Nasopharyngeal swab
nasopharyngeal swabs
nasopharynx
observé
participant
Participants
performed
Protective
respiratory
respiratory epithelium
response
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 RNA
scRNA-seq
secretory
severe COVID-19
severe disease
susceptibility
target
target cells
underlie
upper respiratory symptoms
Viral
viral loads
viral pathology
[DOI] 10.1016/j.cell.2021.07.023 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.cell.2021.07.023 PMC 바로가기 [Article Type] Article