Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer PatientsArticle Published on 2021-02-082023-06-20 Journal: Cancer cell [Category] Fulltext, MERS, [키워드] Cancer cerebrospinal fluid COVID-19 Encephalopathy Neuroinflammation SARS-CoV-2 [DOI] 10.1016/j.ccell.2021.01.007 PMC 바로가기
Neurological and mental health consequences of COVID-19: potential implications for well-being and labour forceReview Article Published on 2021-02-042022-10-27 Journal: Brain Communications [Category] COVID-19, [키워드] accelerated affecting Alzheimer’s disease Alzheimer’s disease assumption bidirectional Central nervous system characterized cognitive Cognitive decline Cognitive impairment consequence COVID-19 COVID-19 patient delirium dysfunction Factor higher risk Hypothesis illnesses Immune cell implication individuals Infectious disease mental health Neuroinflammation neurological Neurological symptom Neuropsychiatric observation overlap pathophysiological post-operative cognitive dysfunction production loss Psychiatric recent resulting Risk factors similarity the patient the SARS-CoV-2 Treatment variety virus [DOI] 10.1093/braincomms/fcab012 PMC 바로가기 [Article Type] Review Article
Repurposing of Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations: A Valid Option to Control SARS-CoV-2-Associated Neuroinflammation?Letter to the Editor Published on 2021-02-032023-06-16 Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, [키워드] COVID-19 doxycycline Drug repurposing Minocycline Neuroinflammation SARS-COV-2 infection [DOI] 10.1007/s11481-021-09986-3 PMC 바로가기 [Article Type] Letter to the Editor
COVID-19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseasesCOVID-19와 후각 기능 장애: 신경 퇴행성 질환에 대한 가능한 연관 접근법Review Published on 2021-02-012022-09-11 Journal: Journal of cellular physiology [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect agent Anosmia approach associative Brain cellular Central nervous system chronic infection CNS conditions coronavirus COVID-19 disease dysfunction Fever globe Health care health care workers Host Hypogeusia Hyposmia inactive infect lead life-threatening mechanism microglia nasal epithelium neurodegenerative neurodegenerative disorders Neuroinflammation Neuron Novel coronavirus olfactory olfactory bulb olfactory bulb dysfunction. phenotype respiratory SARS-CoV-2 SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus Shortness of breath sore throat suggested symptoms of COVID-19 the SARS-CoV-2 tissue tissues virus [DOI] 10.1002/jcp.29937 PMC 바로가기 [Article Type] Review
Targeting Neurological Manifestations of Coronaviruses by Candidate Phytochemicals: A Mechanistic ApproachPharmacology Published on 2021-01-202022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome angiotensin-converting enzyme 2 candidate caused Central nervous system combating complex complications complications of COVID-19 conducted coronavirus Coronaviruses COVID-19 delirium dysregulated Efficacy Evidence homology introduced lack manifestation Manifestations mechanisms Middle East nervous system Neuroinflammation neurological neurological manifestations neurological sign NEUROLOGY neuronal neuronal mechanisms Novel coronavirus Pain pathophysiological mechanism pharmacological Pharmacology phytochemicals protease Proteins provided respiratory RNA-dependent RNA polymerase SARS-CoV SARS-CoV-2 Secondary Metabolite signaling pathways stroke targeting therapeutic agent therapeutic target Treatment Web of Science [DOI] 10.3389/fphar.2020.621099 PMC 바로가기 [Article Type] Pharmacology
Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 MiceK18-hACE2 마우스에서 SARS-CoV-2의 비강내 접종 후 신경 침범 및 뇌염Article Published on 2021-01-192022-09-10 Journal: Viruses [Category] 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Brain brains Cell cell death Central nervous system characterized chemokines CNS Coronavirus-2 correlated COVID-19 cytokine Cytokines declined direct infection Encephalitis exhibited hACE2 hallmark hemorrhage highest humans infect cell Infection Infectious virus Inflammatory response inoculation intranasal K18-hACE2 K18-hACE2 mice leukocyte leukocyte infiltration lung Lungs mice Mortality nasal nasal turbinate Neuroinflammation neuroinvasion Neurological disease neuronal olfactory olfactory bulb Onset Pathogenesis pathogenesis of SARS-CoV-2 plaque-forming unit plaque-forming units respiratory SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe disease Viral virus titer virus titers [DOI] 10.3390/v13010132 PMC 바로가기 [Article Type] Article
Molecular Mechanisms of Proteins — Targets for SARS-CoV-2 (Review)단백질의 분자 메커니즘 — SARS-CoV-2의 표적(검토)Review Published on 2020-12-282022-09-10 Journal: Modern Technologies in Medicine [Category] MERS, SARS, 치료기술, 치료제, [키워드] accumulating ACE2 Activation Affect affected angiotensin Angiotensin 1-7 Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 astrogliosis basal ganglia blood-brain barrier Brain brain damage brain damage in COVID-19 brain tissue breakdown caused CD147 Central nervous system Cerebellum change CNS coronavirus Coronavirus infection COVID-19 Cytokines damage death develop disease Diseases driven by Endothelial cell endothelial cells enzyme Evidence exposure to expressed Extracellular matrix functional ganglia help hypothalamus inducer Infection information interactions leads leukocyte leukocytes Local massive matrix metalloproteinases mechanisms membrane permeability metabolism microglia midbrain molecular mechanism molecular mechanisms moment nasal epithelium Neuroinflammation neurons Neurovascular New coronavirus new coronavirus SARS-CoV-2 pathogen Pathogenesis pathogenesis of COVID-19 Piriform cortex Proinflammatory cytokine proinflammatory cytokines pulmonary symptoms Research review SARS-CoV-2 Serine serine protease serine protease TMPRSS2 substantia substantia nigra target target proteins the disease TMPRSS2 Treatment Vascular Via virus virus spread [DOI] 10.17691/stm2020.12.6.11 PMC 바로가기 [Article Type] Review
Case Report: Famotidine for Neuropsychiatric Symptoms in COVID-19Medicine Published on 2020-12-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute COVID-19 acute illness Administered Anxiety baseline binding cognitive Controlled COVID-19 COVID-19 pandemic Depression Diagnostic Criteria Effect Famotidine famotidine (FAM) feature Follow-up had no impairment improvement in silico include initial medications Neuroinflammation Neuropsychiatric Patient progression Psychiatric psychiatric history psychiatry reported Research retrospective SARS-CoV-2 SARS-CoV-2 drug Side effects survival sustained Symptom symptomatic Symptoms targets the patient to define Treatment treatment for COVID-19 with COVID-19 [DOI] 10.3389/fmed.2020.614393 PMC 바로가기 [Article Type] Medicine
Does COVID‐19 contribute to development of neurological disease?Review Published on 2020-12-172022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor activated acute respiratory syndrome Brain Central nervous system clinical manifestation CNS consequence Consequences contribute coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 database Depression disease Effect enzyme Evidence expected Express glial cell glial cells Healthcare provider immune mediated demyelination infect Infection information kidneys literature review Lungs memory impairment neurodegeneration Neuroinflammation neurological neurological circuits Neurological complication NEUROLOGY Neuron Olfactory epithelium organ Patient Pneumonia recent receptor Region Research Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Standard Transmission virus [DOI] 10.1002/iid3.387 PMC 바로가기 [Article Type] Review
Investigation of Genetic Variations of IL6 and IL6R as Potential Prognostic and Pharmacogenetics Biomarkers: Implications for COVID-19 and Neuroinflammatory DisordersCommunication Published on 2020-12-162022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Affect binding ability Biomarker Biomarkers Complication COVID-19 disease Diseases disorder distribution expression FIVE General population Genes genetic variants Genetic variation IL6 IL6R implicated IMPROVE Ingenuity Pathway Analysis investigated investigation IPA Italian mechanism Mortality multiorgan failure neurodegenerative neurodegenerative disorders Neuroinflammation Personalized medicine pharmacogenetic pharmacogenetics pleiotropic Potential predicted Prevent Prognosis prognostic progression protocol public health Quality of life rs2228145 SARS-CoV-2 Seven severity susceptibility treatment strategy variant was performed with COVID-19 [DOI] 10.3390/life10120351 PMC 바로가기 [Article Type] Communication