Use of a Humanized Anti-CD6 Monoclonal Antibody (Itolizumab) in Elderly Patients with Moderate COVID-19중등도의 COVID-19가 있는 고령 환자에서 인간화 항-CD6 단클론항체(이톨리주맙)의 사용Clinical Trial Published on 2020-01-012022-09-12 Journal: Gerontology [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome age antibody Antiviral baseline caused circulating Clinical outcome clinical trial clinically Combination Comorbidities Complication Concentration control group control subject coronavirus coronavirus disease Course COVID-19 COVID-19 disease COVID-19 patient Cuba Cytokine release syndrome discharged dose elderly first dose humanized IL-6 ill patient immunomodulatory drugs immunomodulatory therapy individual intensive care itolizumab Local Medical conditions monoclonal antibody Mortality multiple comorbidity outbreak Pathologies Patient patients with COVID-19 polymerase chain positive receive reduce reduced remained reported reverse transcription risk of death SARS-CoV-2 SARS-COV-2 infection severity susceptibility susceptible tested the disease therapeutic took place Transmission treated Treatment Villa was selected worsening [DOI] 10.1159/000512210 PMC 바로가기 [Article Type] Clinical Trial
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogasterDrosophila melanogaster의 식이 의존성 요산 병리학에서 인슐린 유사 신호 전달 경로의 보존된 역할Research Article Published on 2019-08-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affecting AKT2 arising association Author benefit candidate gene cascade changes in chronic disease Chronic diseases clinical Clinical studies component components conserved Coronary artery Coronary artery disease correlation Degradation diabetes disease disorders downstream Drosophila Drosophila melanogaster drug target Effect elevated expression Factor FOXO3 Genetic Gout Human humans Hyperuricemia hyperuricosuria insulin kidney kidney stone kidney stones knockdown mechanism metabolic syndrome metabolism modulating Multiple NADPH NADPH oxidase norm obesity Occurrence opens Pathogenesis Pathologies pathology pathway phenotype plethora potential therapeutic target potential therapeutic targets Protein purine purines raise reduced Regulatory rescued Research respond risk factor serum shown Signaling signaling pathway SNP SNPs sugar Support syndrome to define treat uric acid Urine vascular disorder yeast extract [DOI] 10.1371/journal.pgen.1008318 PMC 바로가기 [Article Type] Research Article
Dynamics of Virus-Specific Memory B Cells and Plasmablasts following Viral Infection of the Central Nervous SystemCellular Response to Infection Published on 2018-10-172022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] antibody Antigen presentation Antiviral ASC Autoimmune B cell B cell responses B cells Brain Cell Central nervous system Central nervous system infections CNS contributing to coronavirus Coronavirus infection CRE Cre recombinase Cytidine deaminase Delayed demonstrated draining lymph node draining lymph nodes Dynamics event exhibiting expressing expression Factor functional GC reaction gcs germinal centers Humoral response Infection Intervention lack Local marker memory B cell mice modulate MONITOR murine nervous Neuroimmunology neurotropic Pathologies peaked phenotypic plasmablast Prevalence prevalent priming progeny promoter proportion Reactions recruited recruitment regulate reporter robust subset Support supported sustained System Tamoxifen Treatment viral encephalomyelitis viral infections viral persistence while [DOI] 10.1128/JVI.00875-18 PMC 바로가기 [Article Type] Cellular Response to Infection
Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after InfectionArticle Published on 2017-08-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] administration alterations Altered Analysis Cardiovascular disorders clinical Clinical treatment Diseases Effect examination finding Glucose Health healthy controls High-dose indicated Infection infections information investigated Lipid lung metabolism metabolome metabolomic Methylprednisolone Pathologies Patient provided pulse questionnaire recovered recruited response SARS patient SARS patients SARS-CoV SARS-like coronavirus serum severe pneumonia significant difference suggested Survivors susceptibility systemic damage the patient treated tumors Year [DOI] 10.1038/s41598-017-09536-z PMC 바로가기 [Article Type] Article
Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous SystemResearch Article Published on 2015-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] affecting Amino acid amino acid change amino acid residue appear ATCC cDNA Central nervous system characterized cleavage cleavage site clone CNS colds contribute convertase coronavirus degenerative demonstrated dissemination Encephalitis etiologies feature functional functions furin-like cleavage site generate Genes glycoprotein HCoV-OC43 Human human respiratory tract identify Impact in viral Infection involved isolate isolates Laboratory less mechanism molecular Mutation nervous neurodegenerative Neuroinvasive neurologic neurological Neurological diseases neurotropic OC43 pathogenic Pathologies pathology Point mutation predominant proportion Proprotein Protein respiratory respiratory pathogen resulting retained S gene S glycoprotein S protein S1 and S2 sequence significantly spike System the S protein variant viral spike virulence virus virus spread while [DOI] 10.1371/journal.ppat.1005261 PMC 바로가기 [Article Type] Research Article
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections안지오텐신 전환 효소 2는 치명적인 조류 인플루엔자 A H5N1 감염으로부터 보호합니다Article Published on 2014-05-062022-09-25 Journal: Nature Communications [Category] Fulltext, 신종인플루엔자, 유전자 메커니즘, 진단, [키워드] ACE2 administration alleviate angiotensin-converting enzyme 2 cause death rates develop downregulation enzyme expression flu H5N1 highly pathogenic human ACE2 inactivation Infection Influenza influenza A Influenza virus information lung lung failure Lung injury Medical research mice Mouse models outbreak Pandemics Pathologies Patient patients Potential treatment PROTECT Respiratory tract diseases serum Serum level severe lung injury severity supplementary material virus [DOI] 10.1038/ncomms4594 PMC 바로가기 [Article Type] Article
Pathogenic Mouse Hepatitis Virus or Poly(I:C) Induce IL-33 in Hepatocytes in Murine Models of HepatitisResearch Article Published on 2013-09-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Acute liver injury addition administration alarmin association cellular controls cytokine down-regulated expressed expressing expression Hepatitis hepatocyte IL-33 in viral Infection involved led to liver Liver injury mice microenvironment Model mouse mouse hepatitis virus murine NK cell NK cells NKT NKT cells over-expressed pathogenic Pathologies Patient poly(I:C post infection pro-inflammatory cytokine receptor Regulation remained sera sinusoidal endothelial cell TLR3 treated up-regulated Vascular vascular endothelial cell Viral hepatitis [DOI] 10.1371/journal.pone.0074278 PMC 바로가기 [Article Type] Research Article