Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage
COVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.
Article
[키워드] accounted
Analysis
analyzed
cardiac hypertrophy
correlated
COVID-19
COVID-19 infection
COVID-19 organ damage
COVID-19 patients gene expression
Critical
Cytokines
damage
deleterious effect
determine
downregulated
downstream
Effect
effective
Effectiveness
eIF2
eukaryotic
eukaryotic initiation factor 2
fibrosis
Host
host protein
host proteins
hypercytokinemia
hypertrophy
IL-17A
IL-2
IL-6
IL-8
immune and inflammatory mechanisms of COVID-19
imperative
induce
Inflammation
Inflammatory
inflammatory genes
inhibitors
inhibitory
initiation factor
innate immune response
Interaction
interleukin
investigation
lead
lung
Lungs
mechanism
Mild
moderate
multiple organ failure
NF-κB
organ
Organ failure
organ injury
organs
overactive
pathway
Pathways
patients
peptide
peptides
potential therapeutic target
potential therapeutic targets
pro-inflammatory cytokine
pro-inflammatory cytokines
Profiling
reduced
RNAseq
SARS-CoV-2
SARS-CoV-2 virus
severe and critical patients
severely infected patients
Severity of infection
single and bulk RNASeq cell profiling and analysis
single-cell
Stimulation
suppress
suppression
therapeutic targets
tissues
translation
Treatment
upregulation
Viral
viral infection
Viral protein
Viral proteins
viral-host protein
was increased
[DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article