Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence AttenuationCryptococcus neoformans var.의 게놈 및 전사체 분석 grubii, 복잡한 RNA 발현 및 독성 약화로 이어지는 소진화를 밝혀냄Research Article Published on 2014-04-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major addition alternative polyadenylation Analysis analyzed annotation attenuation automated C. neoforman CDS chromosomal coding coding DNA sequence coding DNA sequences Comparative analysis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans death Efficiency examination expressed gene expressed genes feature fungi Gene Expression Genes Genetic genetics Genome genome sequence genomic studies genomic study human pathogen identify Immunocompromised Immunocompromised patients in vitro culturing indicate intron introns involved isolate isolates Laboratory leading manual curation meningoencephalitis microevolution microevolutionary miscRNA miscRNAs molecular motif Mutation Non-coding RNAs occur opportunistic pathogen pathogen pathogenic performed phenotypic phenotypic and genome re-sequencing analysis polyadenylation site polyadenylation sites provide Region Regulation Replication representing responses responsible resulting RNA RNA-Seq-based analysis sequence sequenced sequences Sequencing serotype Spectrum strain Stress stress responses Transcription Transcriptome untranslated regions UTRs VAR variant variety virulence yeast [DOI] 10.1371/journal.pgen.1004261 PMC 바로가기 [Article Type] Research Article
Phenotype Ontologies and Cross-Species Analysis for Translational Research번역 연구를 위한 표현형 온톨로지 및 교차 종 분석Review Published on 2014-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aetiology approach approaches comparable computational approach consequence disorders DNA sequence equivalence example Genetic variation hereditary traits human genetic variation identify involved mouse Neuropsychiatric ontologies organism orthologue orthologues phenotype phenotypic resulting significantly statistical traits zebrafish [DOI] 10.1371/journal.pgen.1004268 PMC 바로가기 [Article Type] Review
Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen정량적 유전 발자국과 특성 강화 분석을 결합하여 세균성 병원체의 적합성 결정 요인 식별Research Article Published on 2013-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major abundance Affect Algorithm Antibiotic resistance approach approaches array assortment Author Bacterial bacterial gene bacterial genes benefit bioinformatics candidate gene changes in Combination conjunction conserved dataset deep sequencing deleted determinant determinants Determining diagnostic dissect Diversity DNA binding E. coli effective effort enrichment Escherichia Escherichia coli Factor fitness Follow-up analysis Footprinting found Gene Genes Genetic Genome genomes highest highlight homologue homologues Host hypothetical identify increasingly independent Infection infections insertion investigator investigators isolates Meningitis molecular mouse model Mutagenesis mutant novel observation observations pathogen Pathogenesis pathogenic pathogenic strain pathogenic strains Pathogens phenotypic phenotypic variation phylogenetic distribution promote Quantitative reported required Research resource saturated Sepsis Sequencing shown strain Strains suggested therapeutic therapeutic targets Therapies Tn-seq to define trait transcriptional repressor transposon urinary tract infections variant Variation virulence virulence gene widespread zebrafish [DOI] 10.1371/journal.pgen.1003716 PMC 바로가기 [Article Type] Research Article
Chromosomal Copy Number Variation, Selection and Uneven Rates of Recombination Reveal Cryptic Genome Diversity Linked to Pathogenicity염색체 복사 수 변이, 선택 및 재조합의 불균등한 비율은 병원성과 관련된 비밀 게놈 다양성을 나타냅니다Research Article Published on 2013-08-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive addition Analysis asexual association Author Batrachochytrium dendrobatidis change changes in characterized chromosomal chromosome contribute contributed copy copy number Culture de novo directional Diversity ecological niche ecological niches effort Evidence evidence of Evolution explain Factors feature fungal fungi Gene Genetic Genome genomes growth Host hot spots in vitro infect isolate knowledge Lineage lineages majority manifested mechanism microbial number occur organism pathogen pathogenicity Pathogens phenotypic ploidy Rate Recombination Region replicate reported reproduction response Secretome Selection sequenced target Transmission Variability Variation virulence virulence factors widespread [DOI] 10.1371/journal.pgen.1003703 PMC 바로가기 [Article Type] Research Article
Genetic Mapping of Specific Interactions between Aedes aegypti Mosquitoes and Dengue Viruses이집트숲모기(Aedes aegypti Mosquitoes)와 뎅기열 바이러스(Dengue Viruses) 간의 특정 상호작용의 유전적 매핑Research Article Published on 2013-08-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Aede assigned Author contribute correlation Critical Defense defense mechanisms Dengue dengue virus dengue viruses detected determine discriminatory power explained Factor Factors G×G interaction G×G interactions Genetic genetic architecture genetic factors genetic loci genetic mapping Genome Genotype Health Host host-pathogen interaction immune responses Interaction interactions invertebrate invertebrates isolate loci mapped mapping marker mechanism mechanisms molecular mechanism molecular mechanisms Mosquito mosquito-virus natural population outcome pathogen pathogen genotype pathogen genotypes Pathogens Patient patients phenotype phenotypic phenotypic variation physical Region remained serotype significantly Specific specificity the mosquito Variation vector virus virus isolate viruses [DOI] 10.1371/journal.pgen.1003621 PMC 바로가기 [Article Type] Research Article
High-Resolution Transcriptome Maps Reveal Strain-Specific Regulatory Features of Multiple Campylobacter jejuni Isolates고해상도 전사체 지도는 여러 Campylobacter jejuni 분리주의 균주 특이적 조절 기능을 보여줍니다Research Article Published on 2013-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation addition Analysis analyzed approach Author automated Bacterial bioinformatics Campylobacter Campylobacter jejuni compared consequence conservation conserved contribute CRISPR different DNA ecological niche ecological niches eukaryote eukaryotes facilitate feature functional gastroenteritis Gene Gene Expression Gene regulation Genetic Genome genome sequence Genome sequences genomic variation genomic variations genotypic genotypic variations growth Host hosts humans immune system IMPROVE include integration isolate isolates lead Map maturation modulate Multiple organism Organisms Pathogens pathway phenotypic phenotypic diversity phenotypic variation promoter promoter regions promoters provide Regulation related reveal RNA RNA sequencing RNase similarities similarity small RNA SNP sRNA strain Strains stress conditions time-consuming transcribed transcriptional Transcriptome transcriptomes TSS unique upstream Variation whole-genome [DOI] 10.1371/journal.pgen.1003495 PMC 바로가기 [Article Type] Research Article
MTL –Independent Phenotypic Switching in Candida tropicalis and a Dual Role for Wor1 in Regulating Switching and FilamentationMTL – Candida tropicalis의 독립적인 표현형 전환과 전환 및 필라멘트 조절에서 Wor1의 이중 역할Research Article Published on 2013-03-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition ascomycete Author C. albican C. albicans Candida albican Candida albicans Candida tropicalis Cell cell type cell types cells characterized colonization conserved Deletion dependent on different Efficiency Epigenetic expression filament fungal fungi Gene growth heterozygous homozygous Host in addition to independent independent of induce Infection Interaction locus mammalian master regulator overexpression overlap pathogen pathogenic phenotypic Program promote regulate regulated Regulating Regulation related retained reveal role sexual reproduction switching these cell These cells transcription factor transcription factors transcriptional regulator transition undergo white cell white cells Wor1 yeast form [DOI] 10.1371/journal.pgen.1003369 PMC 바로가기 [Article Type] Research Article
Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies서아프리카 피그미족의 조상 패턴, 자연 선택의 서명 및 키와의 유전적 연관성Research Article Published on 2012-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive African Anatomy ancestry approach association Author average candidate gene chromosome chromosome 3 CISH Cluster cytokine cytokine signaling demography DOCK3 enrichment European Europeans Evolution extreme found Gene Genetic genetic association genetic diversity Genome genomic region globe group growth growth factor growth hormone Height highest Human human population human populations identify Illumina Immunity include indicate inhibit insulin insulin-like growth factor involved Local location loci metabolism natural natural selection neuroendocrine Pathway analysis Pathways pattern phenotypic phenotypic diversity phenotypic variation Physiology Population Positive selection Region regulate reproduction Selection short stature Signaling signaling pathways signature SNP stature target targets the strongest thought tropical unique variant variants Variation [DOI] 10.1371/journal.pgen.1002641 PMC 바로가기 [Article Type] Research Article
Comparative and Functional Genomics of Rhodococcus opacus PD630 for Biofuels Development바이오연료 개발을 위한 Rhodococcus opacus PD630의 비교 및 기능 유전체학Research Article Published on 2011-09-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accurate Actinomycetale Analysis approach assigned Author Bacteria bacterium Biofuel carbon catabolic cellular Comparative Comparative analysis Complete compounds conserved development dry weight Engineering Enzymes eukaryotic Fatty acid fatty acids Gene gene family Genetic Genome genome sequence Genomics growth homologous homologous genes identify implicated included information led to lipid metabolism metabolic product metabolism multidisciplinary approach Pathways performed phenotypic phenotypic information Phylogenetic analysis predicted gene provide provided reaction related Research screened sequenced substrate substrates Support target gene Target genes triacylglycerol working model [DOI] 10.1371/journal.pgen.1002219 PMC 바로가기 [Article Type] Research Article
A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood MalariaA −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West [DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article