An antibody-based proximity labeling protocol to identify biotinylated interactors of SARS-CoV-2SARS-CoV-2의 비오틴화된 상호작용자를 식별하기 위한 항체 기반 근접 라벨링 프로토콜Article Published on 2022-05-022022-09-12 Journal: STAR protocols [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Analysis approach biotinylated Complete Host identify labeling mass mass spectrometry mechanism Microbiology molecular interaction Molecular/Chemical Probes non-specific peptide Protein Biochemistry Proteins proteomics protocol SARS-CoV-2 SARS-CoV-2 protein viral pathogenesis Viral proteins virus [DOI] 10.1016/j.xpro.2022.101406 PMC 바로가기 [Article Type] Article
Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and TherapeuticsResearch article Published on 2022-05-012022-10-05 Journal: JACC: Basic to Translational Science [Category] 바이오마커, 유전자 메커니즘, [키워드] ADAMTS13 cardiovascular cardiovascular complication Case-control cause Cohort COVID-19 COVID-19 patient COVID-19 patients disease severity dominant driving finding FSTL3 identify Implications Injury loss-of-function marker mechanism Microvascular thrombosis Myocardial myocardial injury pathophysiology performed phenotype plasma proteomics protease Protein proteomics senescence Signaling Stress therapeutic Therapeutics [DOI] 10.1016/j.jacbts.2022.01.013 [Article Type] Research article
Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19COVID-19 진단 및 예후를 위한 실험실 바이오마커Review Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] Admission Analysis aspartate Aspartate transaminase AST Biomarker Biomarkers BNP Brain brain natriuretic peptide cause clinical manifestations Clinical practice coronavirus disease Coronavirus disease 2019 COVID-19 creatine creatine kinase Cytokines D-dimer Diagnosis diagnostic disease severity focus Future Hospitalization ICU identify include Inflammation intensive care intensive care unit laboratory biomarker laboratory biomarkers Lactate lactate dehydrogenase LDH Lymphocytes metabolomic metabolomics Mortality multiorgan failure Myoglobin N-terminal Neuron-specific enolase neutrophil neutrophil count Neutrophils NT-proBNP outcome outcomes peptide predict Prognosis Prognostic value progression proinflammatory cytokines proteomic proteomics Research respiratory risk stratification SARS-CoV-2 Severe acute respiratory syndrome severe cases severe COVID-19 shown translated [DOI] 10.3389/fimmu.2022.857573 PMC 바로가기 [Article Type] Review
Multi-omic analysis reveals enriched pathways associated with COVID-19 and COVID-19 severity다중 오믹 분석은 COVID-19 및 COVID-19 심각성과 관련된 풍부한 경로를 보여줍니다Article Published on 2022-04-252022-09-11 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] addition analyses Analysis analyzed approach biological pathway biological pathways Cell cell cycle characterized cholesterol clinical outcomes correlation correlations COVID-19 COVID-19 severity death disease disease severity disease status enriched pathway enrichment analysis hospital identify implicated Inflammatory response metabolic processes metabolomics molecular molecules Multiple observé Pathway analysis Patient predict principal components analysis proteomics reflected regression models reveal RNA sequencing data severity stability Symptoms the disease Vitamin was done with COVID-19 [DOI] 10.1371/journal.pone.0267047 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 Proteins in Wastewater Samples by Mass Spectrometry질량 분석법에 의한 폐수 샘플의 SARS-CoV-2 단백질 검출Article Published on 2022-04-192022-09-11 Journal: Environmental science & technology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Biomarker Chain Reaction collected COVID-19 COVID-19 infection COVID-19 pandemic detection eight Epidemiology feces health system host cell Infection information liquid chromatography−mass spectrometry mass mass spectrometry mass vaccination occurred outbreak peptide peptides polymerase chain polymerase chain reaction pp1ab Protein proteomics quantification Quantitative quantitative polymerase chain reaction Sample SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 RNA SARS-CoV-2 virus Spectrometry the SARS-CoV-2 virus These data transcribed Treatment unique Urine vaccination wastewater [DOI] 10.1021/acs.est.1c04705 PMC 바로가기 [Article Type] Article
The Dysregulation of the Renin-Angiotensin System in COVID-19 Studied by Serum Proteomics: Angiotensinogen Increases with Disease Severity혈청 단백질체학으로 연구한 COVID-19에서 레닌-안지오텐신 시스템의 조절장애: 질병의 중증도에 따라 안지오텐시노겐 증가Article Published on 2022-04-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] ACE Activation AGT analyses Analysis angiotensin angiotensinogen bradykinin Cohort complement Complement activation Concentration convalescent coronavirus correlated COVID-19 COVID-19 infection CPN Critically ill critically ill patients disease severity expression expression analysis followed by group healthy probands hospitalized COVID-19 patients hospitalized patient hospitalized patients increase indicated Infection investigated Kallikrein Kallikrein-kinin system KLKB1 KNG1 mass spectrometry pathophysiological pathway patients plasminogen profile Protein protein expression proteomics RAS Renin renin-angiotensin system separated serum Serum protein significantly statistical System was performed [DOI] 10.3390/molecules27082495 PMC 바로가기 [Article Type] Article
Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue지방 조직의 크레아틴 키나아제 상향 조절과 관련된 척수 손상 환자의 욕창 수술 후 코로나바이러스 후 합병증Article Published on 2022-04-092022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] adipose Adipose tissue analyzed Associate autoantibodies autoantibody Biomarker CKM CKMT2 CKs Complication complications CORD correlation Covid patients COVID-19 COVID-19 diagnosis COVID-19 pandemic creatine Diagnosis identify Infection Inflammatory response Injury kinase mechanism MGCs Patient patients patients with SARS-CoV-2 post-translational modification post-translational modifications postoperative Postoperative Complications Predictive pressure pressure ulcer pressure ulcers progression Protein proteomic proteomics PU reconstructive surgery Registered risk SARS-CoV-2 SARS-COV-2 infection SCI serum significantly increased spinal spinal cord Spinal cord injury surgery Surgical Procedure tissue ulcer underlie upregulated [DOI] 10.3390/cells11081282 PMC 바로가기 [Article Type] Article
The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivoCOVID-19 무증상 환자의 혈청은 생체 외 순환하는 혈관 신생 세포에서 내피 기능 장애 및 바이러스 반응과 관련된 단백질을 상향 조절합니다Article Published on 2022-04-092022-09-12 Journal: Molecular Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] Activation acute respiratory syndrome applied approach Asymptomatic Asymptomatic COVID-19 asymptomatic individual Asymptomatic individuals asymptomatic patient caused Cell cellular change circulating Circulating angiogenic cells Coagulation coronavirus correlated COVID-19 COVID-19 negative critical COVID-19 patients death Donor donors endothelial Endothelial dysfunction Endothelial progenitor cells evaluated Ex vivo Factor highest ICAM-1 identify IgG immune response incubated individuals Infection infective Inflammatory Inflammatory response inhibitor initial machine learning algorithm marker pathway PCR platform positive potential long-term sequelae promote promoted Protein protein level proteomics provoke Quantitative responsible SARS-CoV-2 SARS-COV-2 infection serum significantly Stage Symptoms Thromboembolic event TLR2 transmissions treated triggered understanding up-regulate up-regulated Vascular Vascular damage viral infection virus virus entry while [DOI] 10.1186/s10020-022-00465-w PMC 바로가기 [Article Type] Article
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaquesAd26.COV2.S는 햄스터와 붉은털 원숭이에서 SARS-CoV-2 유도 염증 및 혈전증 경로의 상향 조절을 방지합니다Article Published on 2022-04-082022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Ad26 Ad26.COV2.S Adaptive immune response Adenovirus animal models B cell B.1.351 binding comparable complement COVID-19 COVID-19 pathogenesis expressing feature golden hamsters hamster hamsters human disease immune responses immunization induce Inflammation Inflammatory molecular mechanism molecular mechanisms mRNA expression profile mRNA expression profiles myeloid Neutralizing antibody response neutralizing antibody responses Pathogenesis pathway Pathways Prevent prevented Protective proteomics recent rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 WA1/2020 serotype severe COVID-19 severe disease shown Spike protein stimulate Syrian golden hamster Syrian Golden hamsters These data thrombosis transcriptional type I interferon uninfected upregulation vaccination Vaccine Vaccines weight loss with COVID-19 [DOI] 10.1371/journal.ppat.1009990 PMC 바로가기 [Article Type] Article
Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19Original Research Published on 2022-04-052023-07-02 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, [키워드] antibodies Asymptomatic COVID-19 Inflammation Innate immunity proteomics SARS-CoV-2 serum [DOI] 10.3389/fimmu.2022.821730 PMC 바로가기 [Article Type] Original Research