Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials비타민 C와 코로나19 치료: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-11-012022-09-11 Journal: Diabetes & metabolic syndrome [Category] 임상, 치료법, [키워드] 95% CI administration Analysis Ascorbate ascorbic acid benefit carried control group coronavirus coronavirus disease COVID COVID 19 COVID penumonia COVID-19 disease dose hospital ICU Invasive mechanical ventilation l-ascorbate. Meta-analysis oral Patient Randomized controlled trial Randomized controlled trials Ratio RCT reduce mortality risk ratio route SARS-CoV-2 severity severity of illness SMD systematic review Total Treatment Viral illness viral illnesses Vitamin Vitamin C [DOI] 10.1016/j.dsx.2021.102324 PMC 바로가기 [Article Type] Meta-Analysis
Vitamin C Intervention for Critical COVID-19: A Pragmatic Review of the Current Level of EvidenceReview Published on 2021-11-012022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome adverse event antioxidant appear ARDS cause characterized clinical trial clinical trials coronavirus coronavirus disease COVID-19 COVID-19 patients current decrease dose elevated Evidence FIVE hospital IMPROVE Infection Inflammation inflammatory markers Intervention intravenous intravenous vitamin C less Level Oxygenation parameters patients with pneumonia Pneumonia randomised controlled trial Randomised controlled trials RCT RCTs reactive oxygen specy reduce reduce mortality reported respiratory infection retrospective cohort review ROS SARS-CoV-2 SARS-CoV2 Sepsis Seven severe cases severely ill patients severity survival rate syndrome the disease Trial Upcoming Vitamin Vitamin C with COVID-19 [DOI] 10.3390/life11111166 PMC 바로가기 [Article Type] Review
Tocilizumab administration for the treatment of hospitalized patients with COVID-19: A systematic review and meta-analysis코로나19 입원환자 치료를 위한 토실리주맙 투여: 체계적 고찰 및 메타분석Review Published on 2021-11-012022-09-12 Journal: Respirology (Carlton, Vic.) [Category] MERS, SARS, 진단, [키워드] 95% CI administration Admission benefit clinically composite endpoint coronavirus coronavirus disease Corticosteroids COVID-19 Cytokine storm Effectiveness Efficacy evaluate Hospitalization hospitalized COVID-19 patients hospitalized patient ICU improved mortality IMV intensive care Invasive mechanical ventilation lower mortality management Meta-analysis Mortality nine non-ICU patient non-ICU patients observational studies observational study outcome Patient patients Randomized controlled trial RCT RCTs receiving reduction reduction in risk SARS-CoV-2 searched Secondary objective subgroup systematic review systemic corticosteroids Tocilizumab Treatment was reduced [DOI] 10.1111/resp.14152 PMC 바로가기 [Article Type] Review
Underrepresentation of older adults in clinical trials on COVID-19 vaccines: A systematic reviewReview article Published on 2021-11-012022-10-05 Journal: Ageing research reviews [Category] SARS, 임상, [키워드] Abstract addressed affected age clinical trial consequence COVID-19 COVID-19 pandemic COVID-19 vaccine Efficacy evaluate fraction Inclusion Intervention less Older Older adults older subject participant Prevent randomized clinical trial RCT RCTs retrieved systematic literature search systematic review the disease the mean vaccination Vaccine was performed [DOI] 10.1016/j.arr.2021.101455 [Article Type] Review article
Hydroxychloroquine plus azithromycin early treatment of mild COVID-19 in an outpatient setting: a randomized, double-blinded, placebo-controlled clinical trial evaluating viral clearance외래 환자 환경에서 경증 COVID-19의 하이드록시클로로퀸과 아지스로마이신 조기 치료: 바이러스 제거를 평가하는 무작위, 이중 맹검, 위약 대조 임상 시험Randomized Controlled Trial Published on 2021-11-012022-09-11 Journal: International journal of antimicrobial agents [Category] 임상, 치료법, 치료제, [키워드] 95% CI adverse effects Analysis Azithromycin cardiovascular event Chest computed tomography clearance rate clinical evolution Comorbidities Computed tomography conducted Controlled clinical trial COVID-19 criteria demographic characteristics double-blinded early treatment Efficacy Endpoint enrolled enrolment evaluated Evolution group Hospitalization Hydroxychloroquine hydroxychloroquine plus azithromycin in some in viral In vitro studies inclusion criteria intention-to-treat Mild mild SARS-CoV-2 infection outcome Outpatient outpatients participant Patient per-protocol performed Placebo placebo-controlled clinical trial POCT positive PP analysis primary endpoint randomised Randomized RCT reducing SARS-CoV-2 SARS-COV-2 infection screening test secondary Secondary endpoints Secondary outcomes shown significantly statistical analyses statistically significant Support Swab Symptom Treatment trial participants viral clearance viral clearance rate viral clearance rates Viral load viral load reduction viral loads viral replication [DOI] 10.1016/j.ijantimicag.2021.106428 PMC 바로가기 [Article Type] Randomized Controlled Trial
Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTsShort Report Published on 2021-10-312022-10-30 Journal: Nutrition Journal [Category] COVID-19, MERS, SARS, [키워드] aggravate association Clinical outcome cohort study coronavirus disease COVID-19 COVID-19 infection current database death decrease deficiency Efficacy Evidence hospitalized patient ICU admission IMPROVE improve clinical outcome In-hospital death increase in increased risk Infection Meta-analysis nutrition outcome Patient patients with COVID-19 Randomized controlled trial RCT RCTs recommendation reported Result risk risk of COVID-19 significantly suggested supplementary material susceptibility Vitamin D vitamin D deficiency vitamin D level Vitamin D supplementation were assessed [DOI] 10.1186/s12937-021-00744-y PMC 바로가기 [Article Type] Short Report
Equivalency of Protection From Natural Immunity in COVID-19 Recovered Versus Fully Vaccinated Persons: A Systematic Review and Pooled AnalysisInfectious Disease Published on 2021-10-282022-10-31 Journal: Cureus [Category] COVID-19, [키워드] a systematic review added addition Analysis article benefit Case-control case-control study clinical study cohorts Complete conducted COVID COVID-19 COVID-19 vaccines effective Efficacy eligibility FDA group groups Guidance identify incidence individual individuals Infection naïve natural natural immunity nine NNT NOS observational study Patient patients performed pooling populations Prevent prospective observational cohort protection provided Randomized controlled studies ranged RCT RCTs recovered Reinfection reported representing retrospective review risk risk ratio SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 reinfection severe COVID-19 disease statistical statistically significant subject subsequent systematic review treat vaccination was performed while [DOI] 10.7759/cureus.19102 PMC 바로가기 [Article Type] Infectious Disease
Efficacy and safety of IL-6 inhibitors in patients with COVID-19 pneumonia: a systematic review and meta-analysis of multicentre, randomized trialsResearch Published on 2021-10-262022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 95% CI acute respiratory distress syndrome administration adverse event adverse events all-cause mortality characterized control group COVID-19 COVID-19 adult patient COVID-19 patients criteria Cytokine storm dysregulated immune response eligible finding Follow-up hospitalized patients hyperinflammation Hypothesis IL-6 IL-6 inhibitor immunomodulation IMPROVE incidence independent intubation intubation rate Intubation rates investigated investigator involved majority material Meta-analysis Microclots Mortality mortality rate multicentre no increase Open-label outcome patients patients with COVID-19 performed randomized trial RCT RCTs reduced reduction in Respiratory failure Result searched secondary secondary infections standard treatment supplementary material systematic review Tocilizumab Trial trials [DOI] 10.1186/s13613-021-00941-2 PMC 바로가기 [Article Type] Research
The Use of Tocilizumab in Patients with COVID-19: A Systematic Review, Meta-Analysis and Trial Sequential Analysis of Randomized Controlled StudiesReview Published on 2021-10-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval all-cause mortality approach carried Clinical practice Comparator group composed conducted Controlled coronavirus disease COVID-19 COVID-19 patient COVID-19 pneumonia database Efficacy eligible feature heterogeneity inclusion criteria information Meta-analysis moderate nine outcome Patient performed randomized clinical trial RCT RCTs receptor required review SARS-CoV-2 searched severe COVID-19 severe disease subgroup analysis survival odd systematic review TCZ the disease therapeutic therapeutic option Tocilizumab Treatment trial sequential analysis TSA type I [DOI] 10.3390/jcm10214935 PMC 바로가기 [Article Type] Review
Dissemination interventions to improve healthcare workers’ adherence with infection prevention and control guidelines: a systematic review and meta-analysisSystematic Review Published on 2021-10-242022-10-29 Journal: Implementation Science : IS [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval activities Acute respiratory tract infections adherence approach Care certainty Clinical practice guideline Cluster Combined Compliance conducted COVID-19 COVID-19 pandemic dissemination Effect Evidence Guideline adherence had no Health Health personnel health system healthcare healthcare worker high risk hygiene Implementation outcomes Implementation strategies IMPROVE Infection prevention Infection prevention and control Infectious disease Influenza Intervention knowledge Local Meta-analysis pandemic Prevent random-effects model Randomized controlled trial RCT RCTs respiratory infectious disease Result risk searched systematic review vaccination [DOI] 10.1186/s13012-021-01164-6 PMC 바로가기 [Article Type] Systematic Review