Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans인간 곰팡이 병원체 Cryptococcus neoformans에서 Ras1, Cdc24 및 Ptp3의 고유한 역할을 통한 저산소 반응의 분자 메커니즘Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin affected Analysis biological processe biological processes C. neoforman C. neoformans CAMP caused Cdc42 central gene chromosome Compound Concentration condition conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoskeletal Deletion downstream eight ergosterol eukaryotic cells expression of gene family function fungal genes encoding genetic analysis genotoxic growth growth defect growth retardation GTPase guanine Human human host hypoxia hypoxic hypoxic condition hypoxic conditions indicated inhibit inhibitor involved maintenance molecular mutant not affected nucleotide osmotic oxygen pathogen pathway Pathways phosphatase phosphatases Phosphorylation Protein protein translation Rac1 Rac2 regulate required rescued response Rho GTPase RNA RNA sequencing role sequence similarity single cells strain Strains suggested suppressor These cells Tolerance unique wild-type strain [DOI] 10.1371/journal.pgen.1004292 PMC 바로가기 [Article Type] Research Article
Transcriptional profiling of feline infectious peritonitis virus infection in CRFK cells and in PBMCs from FIP diagnosed catsResearch Published on 2013-11-092022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Analysis Apoptosis caused Cell cells CLC bio coronavirus CrFK determinant diagnosed differentially expressed differentially expressed gene disease down-regulated enteric expression expressions FDR Felis FIPV Fold change functions Gene Gene Expression Genes healthy homogeneous host gene expression Illumina Infected infected cell Infection infectious majority mapped MOST mutant PBMC PBMCs PD-L1 peripheral peritonitis post infection produced Rate reference genome regulated Regulation Result RNA sequencing RT-qPCR sequenced sequencing approach significantly statistical analysis Th1 cell transcriptional Transcriptome up-regulated virulence virulent virus virus infection was used [DOI] 10.1186/1743-422X-10-329 PMC 바로가기 [Article Type] Research
High-Resolution Transcriptome Maps Reveal Strain-Specific Regulatory Features of Multiple Campylobacter jejuni Isolates고해상도 전사체 지도는 여러 Campylobacter jejuni 분리주의 균주 특이적 조절 기능을 보여줍니다Research Article Published on 2013-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation addition Analysis analysis analyzed approach Author automated Bacterial bioinformatics Campylobacter Campylobacter jejuni compared consequence conservation conserved contribute CRISPR different DNA ecological niche ecological niches eukaryote eukaryotes facilitate feature functional gastroenteritis Gene Gene Expression Gene regulation Genetic Genome genome sequence Genome sequences genomic variation genomic variations genotypic genotypic variations growth Host hosts humans immune system IMPROVE include integration isolate isolates lead Map maturation modulate Multiple organism Organisms Pathogens pathway phenotypic phenotypic diversity phenotypic variation promoter promoter regions promoters provide Regulation related reveal RNA RNA sequencing RNase similarities similarity small RNA SNP sRNA strain Strains stress conditions time-consuming transcribed transcriptional Transcriptome transcriptomes TSS unique upstream Variation whole-genome [DOI] 10.1371/journal.pgen.1003495 PMC 바로가기 [Article Type] Research Article