High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease SeverityCOVID-19 환자에서 낮은 친화도 항체의 높은 역가는 질병 중증도와 관련이 있습니다Article Published on 2022-04-132022-09-12 Journal: Frontiers in Immunology [Category] Coronavirus, COVID19(2023년), SARS, 진단, [키워드] addition Affect affinity analyzed antibodies antibody production Antibody Response Antibody titer Antigen association binding clinical information coronavirus disease COVID COVID-19 COVID-19 patient Critically ill critically ill patients disease Disease progression disease severity domain epitope mapping humoral IgA IgA antibody IgG IgG antibody titer IgM immunoassay Infectious diseases Interaction investigated isotype material maturation pandemic Patient peptide positive Prognostic marker Protein Proteins RBD SARS-CoV2 sera severity specific antibody SPRi (surface plasmon resonance imagery) the RBD titer viral infection [DOI] 10.3389/fimmu.2022.867716 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19)AZD1222(ChAdOx1 nCoV-19) 백신을 접종한 쥐의 시험관 내 SARS-CoV-2 스파이크 단백질 발현 및 혈액학적 효과Article Published on 2022-04-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adenovirus Adenovirus-vectored vaccine AZD1222 AZD1222 (ChAdOx1 nCoV-19) blood cell cells ChAdOx1 ChAdOx1 nCoV-19 change cleavage cleaved COVID-19 COVID-19 vaccination COVID-19 vaccine detectable Disease progression Effect Evidence expected expression hematologic hematology parameter Hematology parameters host cell host cells Host immune response host immune responses immediate effect immediate effects immune responses immunization immunohistochemistry in vitro in vivo Infection innate immune response intramuscular intravenous investigated mice morbidity morbidity and mortality nCoV neutrophil occurred parameters plasma concentration Platelet platelet activation platelet and white blood cell parameters. produced promote Protein prothrombotic state Respiratory failure response risk S1 protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein sera severe COVID-19 spike spike glycoprotein Spike protein the S1 subunit undetectable vaccination vectored vaccine vehicle Viral Viral particles White blood cell [DOI] 10.3389/fimmu.2022.836492 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMINARTY vaccine (Pfizer/BioNTech)SARS-CoV-2 스파이크 잔기 616/644 및 1138/1169는 COVID-19 mRNA COMINARTY 백신에서 2개의 항체 에피토프를 나타냅니다(화이자/바이오엔텍)Article Published on 2022-04-092022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody epitope Antibody Response Antigen B-cell epitope BALB/c mice conjugate contribute coronavirus SARS-CoV-2 COVID-19 COVID-19 mRNA vaccines COVID-19 recovered patients COVID-19 vaccine COVID-19 vaccines effective Efficacy effort ELISA assay full-length identify immune immunogenic individuals linear B-cell epitope mRNA peptide peptide-based performed Pfizer-BioNTech Pfizer/BioNTech Protective question raise recipient residue responsible SARS-CoV-2 spike SARS-CoV-2 spike protein sera the SARS-CoV-2 the spike protein Vaccine worldwide pandemic [DOI] 10.1038/s41598-022-10057-7 PMC 바로가기 [Article Type] Article
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2미세유체 항체 친화성 프로파일링은 SARS-CoV-2에 대한 방어에서 기억 재활성화 및 교차 반응성의 역할을 보여줍니다Article Published on 2022-04-082022-09-12 Journal: ACS Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute SARS-CoV-2 infection ADE adverse effect affinity Against antibody antibody affinity antibody concentration antibody profiling Antibody-dependent enhancement Antigen Concentration convalescent coronavirus Course COVID-19 COVID-19 convalescent patient COVID-19 patient cross-reactive antibodies cross-reactive antibody cross-reactivity Determining detrimental effect effort ELISAs endemic human coronavirus enzyme-linked immunosorbent assay evaluate HCoV-HKU1 HCoV-NL63 humoral immune response Immunity Infection memory memory B-cell memory immunity Microfluidics new SARS-CoV-2 nine parameter Pathogens Profiling Reactivation recent role SARS-CoV-2 SARS-COV-2 infection sequence similarity sera seropositive severity Spike protein the SARS-CoV-2 [DOI] 10.1021/acsinfecdis.1c00486 PMC 바로가기 [Article Type] Article
Th2-Oriented Immune Serum After SARS-CoV-2 Vaccination Does Not Enhance Infection In VitroSARS-CoV-2 백신 접종 후 Th2 지향 면역 혈청은 시험관 내 감염을 증가시키지 않습니다Article Published on 2022-04-082022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] accompanied acute respiratory syndrome ADE Adjustment adjuvant aluminum aluminum adjuvant Antibody-dependent enhancement antibody-dependent enhancement of infection Antigen cell line coronavirus Efficacy examined expression pattern Fc receptors Human immune Immune cell immunization immunopathology in vitro inactivated Inactivated SARS-CoV-2 vaccine Infection infiltration lung MERS-CoV mice Middle East neutralizing antibody Neutralizing antibody titer preclinical study Pseudotyped virus respiratory syndrome coronavirus response risk S1 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 virus sera serum Spike protein spike protein subunit vaccine. subunit T helper tested Th2 the SARS-CoV-2 Vaccine virus [DOI] 10.3389/fimmu.2022.882856 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 antibodies in febrile patients from an endemic region of dengue and chikungunya in Peru페루의 뎅기열 및 치쿤구니야 풍토병 지역의 발열 환자에서 SARS-CoV-2 항체 검출Article Published on 2022-04-082022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody Arboviruses Chikungunya clinical suspicion Co-infection conjunctivitis cross-sectional cross-sectional study Dengue detection Diagnosis differential diagnosis disease Endemic enrolled febrile febrile illness febrile patient Febrile patients Fever followed by hands healthcare IgM antibodies IgM antibody Infection majority material Misdiagnosis molecular novel SARS-CoV-2 virus pathogen Pathogens Patient performed positive public health raised rapid expansion Region reported SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgM SARS-COV-2 infection SARS-CoV-2 virus sera serological serum study groups study period suspected diagnosis Symptom was performed [DOI] 10.1371/journal.pone.0265820 PMC 바로가기 [Article Type] Article
Host-pathogen dynamics in longitudinal clinical specimens from patients with COVID-19COVID-19 환자의 종단 임상 표본에서 숙주-병원체 역학Article Published on 2022-04-072022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Analysis average bacterial species bacterial specy ciliated ciliated epithelium co-occurrence collected consensus genome Course COVID-19 cycle threshold cytoskeletal declined deep sequencing deletion variant Differential gene expression differential gene expression analysis dissemination downregulation enrichment Frequency Genetic Genome globe highlight Hospitalized Host immune pressure in vivo increase in individuals Infection low frequencies metagenomic N-terminal domain neutralization potency nonsynonymous variant nonsynonymous variants one patient Patient patients with COVID-19 per day performed Prevalence Rapid reduced Repository SARS-CoV-2 SARS-CoV-2 consensus sequence SARS-CoV-2 consensus sequences SARS-CoV-2 sequencing sequenced Sequencing sera shown specimen spike glycoprotein state subset Surveillance variants Viral viral evolution viral genomes viral loads Washington widespread [DOI] 10.1038/s41598-022-09752-2 PMC 바로가기 [Article Type] Article
Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak일본의 대규모 COVID-19 혈청 감시: Delta에 대한 중화 항체 획득(Omicron에 대해서는 제외) 및 Omicron의 발병을 극복하기 위해 추가 백신 접종 필요Article Published on 2022-04-052022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Analysis analyzed anti-S booster vaccination Cohort collected Concordance Continuous COVID-19 COVID-19 situation Delta delta variant Diagnosis effective Endemic Health Immunity individual Japan mass vaccination much lower Neutralizing activity neutralizing antibody omicron outbreak overcome reached SARS-CoV-2 variant SARS-CoV-2 variants sera seropositive vaccination vaccination rate [DOI] 10.1371/journal.pone.0266270 PMC 바로가기 [Article Type] Article
Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern베타, 델타 및 기타 우려되는 SARS-CoV-2 변이체에 대한 BBIBP-CorV 백신 유도 혈청의 중화 활성Clinical Trial Published on 2022-04-042022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha antibody BBIBP-CorV Beta boost clinical trial Cohort coronavirus Delta Gamma global pandemic Host immune response host immune responses immune responses immunogenicity inactivated indicate Iota neutralization neutralization potency Neutralizing recipient recipients reduction in Registered respiratory SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome Coronavirus term Vaccinations Vaccine vaccine dose variant variants [DOI] 10.1038/s41467-022-29477-0 PMC 바로가기 [Article Type] Clinical Trial
Six-month humoral response to mRNA SARS-CoV-2 vaccination in patients with multiple sclerosis treated with ocrelizumab and fingolimodocrelizumab 및 fingolimod로 치료받은 다발성 경화증 환자에서 mRNA SARS-CoV-2 백신 접종에 대한 6개월 체액 반응Article Published on 2022-04-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] age analysed Analysis Antibody Units baseline BAU binding antibody unit binding antibody units BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine Clinical data collected correlation COVID-19 disease each time-point Efficacy elapsed expressed fingolimod first dose HCs healthy control humoral Humoral response IgG IgG antibodies IgG antibody immunological characteristics investigated long term Long term humoral response lymphocyte Lymphocyte count mounted mRNA mRNA vaccine Multiple multiple sclerosis NAb NAbs neutralizing antibody Ocrelizumab Patient positive positive correlation positive response preserved Quantitative receiving SARS-CoV-2 SARS-CoV-2 mRNA vaccine SARS-CoV-2 trimeric spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines sera serum sample serum samples significantly higher Spearman correlation coefficient Spike protein tested the disease the SARS-CoV-2 therapy titre treated Treatment Trimeric spike protein vaccination Vaccine weakened were assessed [DOI] 10.1016/j.msard.2022.103724 PMC 바로가기 [Article Type] Article