The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanDelta SARS-CoV-2 변종은 우한의 조상 균주와 비교하여 K18-hACE2 형질전환 마우스에서 호흡기 질환의 뚜렷한 병원성 패턴을 유도합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis B cells Brain caused CD45 Cell cells clinical disease concern coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Cytokines Delta delta variant dendritic cell dendritic cells disease dissemination hACE2 help Immune escape immune response Increased Infection infiltration Inflammatory inflammatory monocytes intestinal wall intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice kidney lung Lungs manifestation mice Monocytes mouse model multiple tissues no significant difference observation Pathogenesis pathogenicity pattern perivascular inflammation Proinflammatory cytokine proinflammatory cytokines provide respiratory SAME AS SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 shown significant difference significantly lower strain T cells the disease therapeutic intervention therapeutic interventions Therapies tissue damage tissue pathology Transmissibility Treatment strategies two groups variant Wuhan [DOI] 10.1128/mbio.00683-22 PMC 바로가기 [Article Type] Article
Family caregivers’ concerns about advance care planning for home-dwelling people with dementia: a cross-sectional observational study in JapanObservational Study Published on 2022-06-272022-10-05 Journal: BMC Palliative Care [Category] 임상, [키워드] Administered advance advance care planning Attitudes Care Characteristics concerning cross-sectional Dementia family Family caregiver inclusion criteria individual initiated investigated involved Japan Older palliative Palliative care participated professional psychological need Psychological well-being questionnaire reported respondent significantly higher significantly lower WHO-5 Well-being Index [DOI] 10.1186/s12904-022-01008-0 PMC 바로가기 [Article Type] Observational Study
Covid-19 pandemic impacts on follow-up of child growth and developmentCovid-19 전염병이 아동 성장 및 발달의 후속 조치에 미치는 영향Article Published on 2022-06-242022-09-12 Journal: Revista de Saúde Pública [Category] MERS, 진단, [키워드] analyzed autocorrelation Brazil Care children Clusters country difference Follow-up growth Health Impact impacted index Indicator initial median non-parametric tests pandemic ranged reducing reduction Region Registered significantly lower South the median [DOI] 10.11606/s1518-8787.2022056004279 PMC 바로가기 [Article Type] Article
Effect of Cholecalciferol Supplementation on the Clinical Features and Inflammatory Markers in Hospitalized COVID-19 Patients: A Randomized, Open-Label, Single-Center Study입원한 COVID-19 환자의 임상 특징 및 염증 표지자에 대한 콜레칼시페롤 보충제의 효과: 무작위, 공개 라벨, 단일 센터 연구Randomized Controlled Trial Published on 2022-06-232022-09-11 Journal: Nutrients [Category] 바이오마커, 임상, [키워드] 25-hydroxyvitamin D 25(OH)D Affect B cell B cell subsets bolus C-reactive protein caused CD27 CD38 cholecalciferol cholecalciferol supplementation clinical clinical benefit clinical feature Clinical features Concomitant medication Course COVID-19 COVID-19 patients decrease DN B cell DN B cells dose Effect evaluate the effect frequencies Frequency group higher risk Hospitalization Immune status increase in Inflammatory Inflammatory marker inflammatory markers lymphocyte Lymphocyte count lymphocyte counts morbidity neutrophil number of bed observé Patient patients with COVID-19 Randomized receive receiving recent SARS-CoV-2 serum significant difference significant differences significantly higher significantly lower two group two groups Vitamin D Vitamin D supplementation was determined [DOI] 10.3390/nu14132602 PMC 바로가기 [Article Type] Randomized Controlled Trial
Nationwide Effectiveness of First and Second SARS-CoV2 Booster Vaccines During the Delta and Omicron Pandemic Waves in Hungary (HUN-VE 2 Study)헝가리의 델타 및 오미크론 대유행 기간 동안 1차 및 2차 SARS-CoV2 부스터 백신의 전국적인 효과(HUN-VE 2 연구)Observational Study Published on 2022-06-232022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 4th vaccine 95% CI 95% confidence interval B.1.617.2 benefit booster booster dose booster vaccination Booster vaccine booster vaccines control group COVID-19 related mortality death Delta delta variant Delta variant (B.1.617.2) Delta wave demonstrated dose Effectiveness examined groups Hungary immunization immunized lower risk Mortality offered Older age omicron Omicron variant omicron variant (SARS-CoV-2) pandemic rate ratio risk SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV2 SARS-CoV2 infection second significantly lower study population Vaccine vaccine effectiveness variant vulnerable population Wave [DOI] 10.3389/fimmu.2022.905585 PMC 바로가기 [Article Type] Observational Study
Impact of previous cardiac function status assessed by echocardiography on the outcome of COVID-19 Research Published on 2022-06-232022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료법, [키워드] age analyzed anticoagulation association average cardiac function cardiovascular risk factor Clinical characteristics clinical factor COVID-19 Deceased demographic data diastolic died disease Echocardiogram echocardiographic echocardiographic parameter Ejection fraction Factor fatality First wave Gender identify Impact in both groups in-hospital mortality increased mortality individuals information left LVEF male occurred outcome parameter Patient performed predictor preserved prognostic receiving regression analysis ROC Curve SARS-COV-2 infection significant difference significantly significantly lower Spain therapy variable ventricular was performed [DOI] 10.1038/s41598-022-14887-3 [Article Type] Research
Associations of Clinical Factors and Blood Groups With the Severity of COVID-19 Infection in Makkah City, Saudi ArabiaObservational Study Published on 2022-06-212022-10-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] 임상, [키워드] ABO ABO blood groups association Asthma Blood Blood Group chronic kidney diseases city clinical Clinical characteristics clinical factor confirmed COVID-19 case congestive heart failure correlation cough COVID-19 COVID-19 infection COVID-19 patient cross-sectional Deceased Diabetes Mellitus diagnosed disease distress distribution expected Factor Fever Frequency group higher infectivity Hospitalized hospitalized COVID-19 patient hypertension infected patient Infection Kingdom Makkah material medical record Ministry of Health Mortality no significant difference Patient patients PCR phenotype Pneumonia positive positive PCR Prevalence Respiratory failure retrieved Rh blood groups Risk factors risk of death Saudi Arabia severity of COVID-19 significantly increased significantly lower specialist Symptom Symptoms syndrome tested Western region with COVID-19 [DOI] 10.3389/fcimb.2022.870096 PMC 바로가기 [Article Type] Observational Study
COVID-19 Vaccine Fact-Checking Posts on Facebook: Observational StudyObservational Study Published on 2022-06-212022-10-04 Journal: Journal of Medical Internet Research [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI addition alleviate changes in collected conducted COVID-19 COVID-19 vaccine ecosystem Effectiveness emotional expressed Facebook fact checking feature Health health information hospital infodemic information Intervention less media misinformation misinformation correction online information pandemic peaked positive positive attitude progressed public health public sentiment receive sentiment analysis significant increase significantly significantly lower social media statistical analysis steadily decreased the vaccine vaccination Vaccine Vaccine hesitancy [DOI] 10.2196/38423 PMC 바로가기 [Article Type] Observational Study
Impact of COVID-19 by Pandemic Wave among Patients with Gastroenterology Symptoms in the Emergency Departments at a Medical Center in TaiwanObservational Study Published on 2022-06-202022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] acute gastroenteritis affected baseline bleeding center changes in conditions conducted constipation COVID-19 COVID-19 pandemic Department diagnose Emergency emergency department gastro-intestinal bleeding. gastroenteritis Impact less pandemic recorded retrospective significantly lower Taiwan Wave [DOI] 10.3390/ijerph19127516 PMC 바로가기 [Article Type] Observational Study
Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19모유의 단백질체 분석은 COVID-19에 걸린 산모의 초유에서 영양 및 면역 이점을 나타냅니다Article Published on 2022-06-172022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] adaptive Analysis Antiviral antiviral properties antiviral property benefit Breastfeeding breastmilk casein collected colostrum control group COVID-19 COVID-19 patient COVID-19 patients debate epitope Epitopes Evidence evidence of exhibited glycosylation Health Organization healthy donors Human immune immune-related protein immune-related proteins Immunoglobulin Infant Infection lack mass spectrometry mature milk milk molecular basis mother protective effect Protein proteomics recognizing recommendation risk SARS-CoV-2 significantly higher significantly lower Structure total protein unique upregulated viral entry virus virus transmission whey protein. while with COVID-19 World Health Organization [DOI] 10.3390/nu14122513 PMC 바로가기 [Article Type] Article