A review of COVID-19 biomarkers and drug targets: resources and toolsCOVID-19 바이오마커 및 약물 표적에 대한 검토: 리소스 및 도구Review Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 바이오마커, 신약개발, 치료제, [키워드] Analysis artificial intelligence bioinformatics Biomarker Biomarkers Community computational method Computational methods corpus COVID-19 disease Drug repurposing drug target example extreme identify knowledge machine learning molecular outbreak pandemic Patient progression resource risk selected starting Stratification therapeutic options therapeutic target Treatment Vaccine development [DOI] 10.1093/bib/bbaa328 PMC 바로가기 [Article Type] Review
Effect of COVID-19 lockdown on hospital admissions and mortality in rural KwaZulu-Natal, South Africa: interrupted time series analysisObservational Study Published on 2021-03-182022-10-04 Journal: BMJ Open [Category] 임상, [키워드] 2020 COVID-19 pandemic 95% CI adjusted Admission Admissions age all-cause mortality Analysis Care change children clinics Cohort collected contributed COVID-19 Daily death diagnose Diagnosis District Effect Epidemiology exposure hospital Hospital admission in-hospital mortality incidence rate increases in Infant Level lockdown Logistic measure men Mortality National objective paediatrics participant Patient Poisson prevented primary care public health Referral reflected Result risk setting Sex South South Africa stages Stratification subgroups [DOI] 10.1136/bmjopen-2020-047961 PMC 바로가기 [Article Type] Observational Study
Seven decades towards malaria elimination in Yunnan, China중국 윈난에서 말라리아 퇴치를 위한 70년Review Published on 2021-03-122024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] Border malaria Malaria elimination Mass drug administration Stratification [DOI] 10.1186/s12936-021-03672-8 PMC 바로가기 [Article Type] Review
Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for Up to 10 Months after InfectionCommunication Published on 2021-03-082022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] anti-SARS-CoV-2 antibody antibody antibody assay assays change clinically COVID-19 described detect disease severity follow-up study highest Hospitalized IgG immune response inter-individual kinetic Kinetics long-term Long-term follow-up Month Patient presenting reached report reported SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection Serological assay serological response significant difference Stratification symptomatic patient total antibody Variability waning effect were used [DOI] 10.3390/microorganisms9030556 PMC 바로가기 [Article Type] Communication
Trends of COVID-19 Admissions in an Italian Hub during the Pandemic Peak: Large Retrospective Study Focused on Older SubjectsArticle Published on 2021-03-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval Admission age analyzed association chronic disease Chronic diseases clinical feature Comorbidity Coronavirus disease-19 COVID-19 COVID-19 phenotype Disabled exhibited Factor female gender frailty functional hospital Hospitalized involved IQR Italian laboratory data Logistic regression lower mortality Mortality Multimorbidity Odds ratio Older outbreak outcome outcomes pandemic PaO Patient Pneumonia positive RT-PCR Prognosis Prognostic factors radiological feature respiratory impairment Retrospective study rising RT-PCR SARS-CoV-2 Stratification subject Temporal trends trend variable with COVID-19 [DOI] 10.3390/jcm10051115 PMC 바로가기 [Article Type] Article
Improving the Understanding of the Immunopathogenesis of Lymphopenia as a Correlate of SARS-CoV-2 Infection Risk and Disease Progression in African Patients: Protocol for a Cross-sectional StudyProtocol Published on 2021-03-042022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] “COVID-19 African alleles amplification analyses Analysis Apoptosis apoptotic pathways association Bax BCL-2 BCL2L12 Biomarker carried caspase 3 categories caused CD4 collected Comorbidity complete blood count Concentration country COVID-19 COVID-19 complication COVID-19 pandemic cross-sectional Cytokine storm determinant determine Disease progression distribution DNA EDTA ELISA enrolled enzyme-linked immunosorbent expected expression expression level flow cytometry Frequency genetic determinants Genomic DNA genotyped genotypes genotypic genotyping Haplotype Hardy-Weinberg equilibrium Health health system help Hospitalized hospitalized patient Hypovitaminosis D Identifier Immunopathogenesis IMPROVE Improving include individual infected patients infected with SARS-CoV-2 information Lagos Linkage disequilibrium Lymphocyte count lymphopenia MONITOR Nigeria objective Other outcome participant Participants Patient PCR performed phenotypic polymerase chain polymorphism Prevalence Prognosis questionnaire R statistical software report Repurposed drug Result reverse transcribed reverse transcription PCR risk stratification RNA RNA sample RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–positive Sequencing serum sample serum vitamin D severe infections soluble Fas ligand Stratification study outcome T cell assay T lymphocyte Total Travel Treatment treatment regimen understanding vascular cell adhesion VDR venous blood Vitamin D receptor Vitamin D status with COVID-19 [DOI] 10.2196/21242 PMC 바로가기 [Article Type] Protocol
Effect of dexamethasone in patients with ARDS and COVID-19 – prospective, multi-centre, open-label, parallel-group, randomised controlled trial (REMED trial): A structured summary of a study protocol for a randomised controlled trialARDS 및 COVID-19 환자에서 덱사메타손의 효과 – 전향적, 다기관, 공개 라벨, 병렬 그룹, 무작위 대조 시험(REMED 시험): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-03-012022-09-10 Journal: Trials [Category] SARS, 임상, 치료기술, [키워드] (C-reactive protein 24 hour 24 hours administration adrenal gland Adult patients Adverse adverse events age alcohol allergy allocation Antigen ARDS ARDS patients ARMS assumed Barthel Index benzyl alcohol Berlin Berlin criteria Blinding Block randomisation Brazil Breastfeeding C-reactive protein calculated can be used Cardiac arrest Care carried case report form CCI Charlson Comorbidity Index Chemotherapy clinical Comorbidity comparator completion condition conducted consequence Contraception control group Corticosteroid Corticosteroids COVID-19 COVID-19 ARDS patient criteria CRP current Czech Republic Day decision defined detect Dexamethasone dexamethasone 6 mg diagnosed dissemination dose doses Dynamics eCRF Effect Effectiveness Efficacy and safety electronic case report form element eligible Endpoint enrolled enrolment EudraCT evaluate event expected exploratory Factor followed by French gastrointestinal bleeding HFNC hospital hospital discharge Hospital stay hypersensitivity Hypothesis ICU ICU admission ICUs Identifier Immunosuppression immunosuppressive drug immunosuppressive drugs Independence independent independent of Infection infections Inflammatory infusion intensive care unit intensive care units Intervention intervention group intractable intravenously intubate intubation investigational medicinal product investigator investigators Laboratory life malignancy marker mechanical ventilation medical history moderate moderate to severe Mortality nasal nasal cannula number objective observational study once daily Open-label open-label trial outcome oxygen Oxygen therapy PaO parallel-group participant Participation Patient patients with ARDS patients with moderate performed power power of 80% Pragmatic Pregnancy present primary efficacy endpoint primary endpoint protocol Quality of life randomisation randomised randomised controlled trial receive recruitment Registered routine clinical practice RT-PCR Sample size scale secondary Secondary endpoints Septic shock sequence severe ARDS sexual abstinence solution Standard deviation statistical analysis statistician status Stratification stratified Study protocol superinfection supplementary material systemic systemic corticosteroids thrombotic Thrombotic complications title Treatment treatment arm Trial Trial registration two-sided type I type I error university hospital Ventilation ventilator-free day Ventilator-free days Version VFD website WHO [DOI] 10.1186/s13063-021-05116-9 PMC 바로가기 [Article Type] Letter
Six artificial intelligence paradigms for tissue characterisation and classification of non-COVID-19 pneumonia against COVID-19 pneumonia in computed tomography lungs컴퓨터 단층 촬영 폐에서 COVID-19 폐렴에 대한 비COVID-19 폐렴의 조직 특성화 및 분류를 위한 6가지 인공 지능 패러다임Article Published on 2021-03-012022-09-11 Journal: International Journal of Computer Assisted Radiolo [Category] SARS, 치료기술, [키워드] Accuracy Analysis artificial intelligence AUC automatically Bispectrum characterisation classification CNN Cohort Computed tomography computer computer tomography consolidations COVID COVID pneumonia COVID-19 COVID-19 pandemic deep deep learning feasible feature GGO Ground-glass opacities ground-glass opacity high correlation Hypothesis hypothesise Inference Italian lung machine machine learning mechanism Non-COVID-19 offer p-values pandemic Patient patients performance pleural effusion Pneumonia protocol radiological risk separated severity Stratification suggested the disease tissue transfer transfer learning Vaccines validation was used [DOI] 10.1007/s11548-021-02317-0 PMC 바로가기 [Article Type] Article
Characterization of NT-proBNP in a large cohort of COVID-19 patientsCOVID-19 환자의 대규모 코호트에서 NT-proBNP의 특성화Article Published on 2021-03-012022-09-11 Journal: European journal of heart failure [Category] MERS, SARS, 바이오마커, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age arrhythmia Arrhythmias association bleeding characterization clinical criteria Concentration condition confounder confounders consecutive patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Cox model criteria cut-off Diagnosis died during admission elevated Extensive Follow-up hazard ratio heart heart failure IMPROVE Infection large cohort male median Mortality multivariable N-terminal Natriuretic Natriuretic peptides NT-proBNP other conditions Patient patients patients with COVID-19 peptide peptides performed Pneumonia Prognosis prognostic Pulmonary embolism reflect Research respiratory risk stratification SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Stratification Stress study population troponin [DOI] 10.1002/ejhf.2095 PMC 바로가기 [Article Type] Article
Prediction of COVID-19 severity using laboratory findings on admission: informative values, thresholds, ML model performance입원 시 실험실 결과를 사용한 COVID-19 심각도 예측: 유익한 값, 임계값, ML 모델 성능Article Published on 2021-02-262022-08-31 Journal: BMJ Open [Category] MERS, 바이오마커, [키워드] 95% CI activated activated partial thromboplastin time admitted to ICU Alanine alanine aminotransferase Algorithm aPTT aspartate Aspartate aminotransferase AUC Bilirubin Biochemistry bioinformatics Biomarker Biotechnology biotechnology & C reactive protein Clinical use comparable consecutive patient COVID-19 COVID-19 severity creatine creatine kinase CRP cut-off cut-off threshold D-dimer dataset Deterioration disease severity disproportion Dubai Features ferritin fibrinogen Free ICU identify Infectious diseases information information technology intensive care intensive care unit Laboratory Laboratory test Laboratory tests Lactate lactate dehydrogenase lymphocyte Lymphocyte count ML model non-severe cases online tool partial thromboplastin time Patient PCR predict prediction Predictive Prognosis prognosis of patient respiratory respiratory infections returned risk Stratification study cohort subjects threshold threshold value thresholds THROMBOPLASTIN total bilirubin troponin with COVID-19 worsening [DOI] 10.1136/bmjopen-2020-044500 PMC 바로가기 [Article Type] Article