Exposures and suspected intoxications during SARS-CoV-2 pandemic: preliminary results from an Italian poison control centreEM - Original Published on 2021-06-062022-10-30 Journal: Internal and Emergency Medicine [Category] COVID-19, MERS, SARS, [키워드] all age groups Analysis calculate Clinical toxicology concerning Effect event exposure Florence General population Health Home isolation individual Intoxication Italian Italy majority mental health occurred pandemic patients performed Poison Poison control centre poisoning Regional reported SARS-CoV-2 SARS-CoV-2 pandemic score structures suggested the SARS-CoV-2 took place toxicology unit university [DOI] 10.1007/s11739-021-02774-0 PMC 바로가기 [Article Type] EM - Original
Novel and flexible ultrasound simulation with smartphones and tablets in fetal echocardiographyMaternal-Fetal Medicine Published on 2021-06-042022-10-27 Journal: Archives of gynecology and obstetrics [Category] Coronavirus, MERS, SARS, [키워드] addition age COVID-19 pandemic examined fetal fetal echocardiography flexible Gender identify increasingly knowledge less median medical education no significant difference novel patients performed physiological Portable ultrasound simulation proportion Prospective Result significantly significantly higher Structure structures Tablet two group Two-arm Ultrasound education Ultrasound simulator were given [DOI] 10.1007/s00404-021-06102-x PMC 바로가기 [Article Type] Maternal-Fetal Medicine
Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findingsResearch Article Published on 2021-06-022022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, [키워드] Affect Analysis articles Brain Central and peripheral nervous system cerebrospinal fluid Cerebrospinal fluid findings Characteristics clinical manifestations Collaborative effort condition conducted COVID-19 described Electrophysiology ENhance Evidence excluded feature Frequency generate knowledge measure Measures mechanism mortality rate nervous system Neuroimaging neurological neurological impairment Neurological involvement neurological manifestation Neuropathology pathophysiologic pathophysiological mechanism pathophysiology Patient patients patients with COVID-19 Prevalence provided Registered Registration reported Result SARS-CoV-2 SARS-COV-2 infection structures subjects systematic review therapeutic translational [DOI] 10.1186/s12879-021-06185-6 PMC 바로가기 [Article Type] Research Article
Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientistsResearch article Published on 2021-06-012022-10-05 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, [키워드] AutoDock AutoDock vina coronavirus COVID-19 disseminate drug drug candidate drug design experimental validation help homologous information inhibitor Interaction Main protease (Mpro) inhibitor modify molecular docking Molecular modeling tutorial MPro pandemic Pandemics peptide Peptide inhibitor protease protocol provide SARS Coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 Mpro structure-based design Structure-based drug design (SBDD) structures the SARS-CoV-2 UCSF Chimera X-ray X-ray crystallographic structure [DOI] 10.1016/j.ejmech.2021.113390 [Article Type] Research article
Genome-wide analysis of 10664 SARS-CoV-2 genomes to identify virus strains in 73 countries based on single nucleotide polymorphism단일 염기 다형성을 기반으로 73개국의 바이러스 균주를 식별하기 위한 10664 SARS-CoV-2 게놈의 게놈 전체 분석Article Published on 2021-06-012022-09-11 Journal: Virus research [Category] SARS, 변종, 치료법, [키워드] absence addition Analysis applied assessment Care Characteristics Cluster Clustering Clusters code Community Consensus country COVID-19 dataset determine environmental condition Evolution ExoN FIVE function genome-wide analysis Hamming distance Hierarchical hierarchical clustering identify linkage Measures Multiple Multiple sequence alignment mutated Non-synonymous Non-synonymous SNP NSP2 nucleocapsid nucleotide ORF3a performed polymorphism Protein provided Q57H Quantitative reported Research responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain SARS-CoV-2 strains sequence Sequence alignment shown Silhouette single nucleotide Single nucleotide polymorphism SNP SNPs stability structures synonymous SNP T85I tendency Vaccine Vaccine design Validity virus virus strain virus strains Visual website [DOI] 10.1016/j.virusres.2021.198401 PMC 바로가기 [Article Type] Article
What must be done to tackle vaccine hesitancy and barriers to COVID-19 vaccination in migrants?Perspective Published on 2021-05-262022-10-31 Journal: Journal of Travel Medicine [Category] COVID-19, Fulltext, MERS, [키워드] approach COVID-19 COVID-19 vaccination Evidence impacted mechanism migrants structures vaccination Vaccine Vaccine hesitancy [DOI] 10.1093/jtm/taab048 PMC 바로가기 [Article Type] Perspective
COVID-19 and future pandemics: a global systems approach and relevance to SDGsDebate Published on 2021-05-212022-11-01 Journal: Globalization and Health [Category] COVID-19, [키워드] added addressed anthropogenic approach Community COVID-19 COVID-19 pandemic Culture determinant ecological ecosystem equity Factors FIVE global governance Goal growth Health Human identify Interaction mechanism Modification origin pandemic Pandemics physical political economy Prevent recognize RNA virus SDGs social environment Spread structures systems Transmission vaccination [DOI] 10.1186/s12992-021-00711-6 PMC 바로가기 [Article Type] Debate
Exploration of the impact of the COVID-19 pandemic on people with dementia and carers from black and minority ethnic groupsPublic Health Published on 2021-05-182022-10-28 Journal: BMJ Open [Category] COVID-19, Fulltext, SARS, [키워드] adjust adult palliative care affected Anxiety Asian Bame Care caused Community community effort Consequences COVID-19 COVID-19 pandemic daily living death Dementia Effect eight ethnic group exploration fear group identity Impact impacted interactions Isolation objective Older Palliative care pandemic participant Perspective Population recruited respondent Result social isolation South Asian structures Support thematic analysis unique [DOI] 10.1136/bmjopen-2021-050066 PMC 바로가기 [Article Type] Public Health
An Integrated Computational and Experimental Approach to Identifying Inhibitors for SARS-CoV-2 3CL ProteaseMolecular Biosciences Published on 2021-05-172022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] 3CL 3CL protease inhibitors 3CLpro accelerate approach candidate caused Compound computational approach coronavirus COVID-19 pandemic docking docking results enzyme activity estimate evaluate evaluated IC50 identify identifying inhibited inhibitor inhibitory effect physicochemical property protease protein-ligand protocol QSAR Quantitative Replication SARS-CoV-2 selected small molecule inhibitor Structure structures the SARS-CoV-2 therapeutic intervention virus [DOI] 10.3389/fmolb.2021.661424 PMC 바로가기 [Article Type] Molecular Biosciences
Repurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicaseArticle Published on 2021-05-132022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Amino acid amino acids analyses Analysis analyzed approach approaches binding energy binding site conserved develop domains drug Drug discovery Drug screening drugs exhibiting Helicase human coronaviruses in silico approaches inhibitors of SARS-CoV-2 Interaction Medicinal chemistry molecular molecular docking Mutation Nucleic-acid therapeutics pandemic PDB performed Protein repurposing residue respiratory RMSD SARS-CoV-2 strong interaction structures suppress Target identification Target validation therapy unlikely Vaccine viral replication virus [DOI] 10.1038/s41598-021-89724-0 PMC 바로가기 [Article Type] Article