Impact of the First Phase of the COVID-19 Pandemic on the Acquisition of Goods and Services in the Italian Health SystemArticle Published on 2022-02-112022-10-30 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] Analysis Brescia carried caused COVID cases COVID-19 COVID-19 pandemic crisis deviate effective Emergency management equipment Escalation event Good hospital Impact intensive care unit Italian management pandemic phase PPE procedure Purchasing respond service subsequent supply chain management System Variation widespread [DOI] 10.3390/ijerph19042000 PMC 바로가기 [Article Type] Article
Lipid Nanoparticle Delivery Systems to Enable mRNA-Based TherapeuticsReview Published on 2022-02-112022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] approval approved candidate clinically COVID-19 delivery develop disease Efficacy Emergency use evaluated gene editing genetic disease Genetic diseases global pandemic issue lesson Lipid Lipid nanoparticles LNP mRNA mRNA platform mRNA-based mRNA-based therapeutics mRNA-based vaccine mRNA-LNP nanoparticle Onpattro Pharmaceutics platform prophylactic vaccines PROTECT SARS-COV-2 infection siRNA-LNP Spread System therapeutic Therapeutics translation treat Treatment University of Pennsylvania utility Vaccine [DOI] 10.3390/pharmaceutics14020398 PMC 바로가기 [Article Type] Review
SARS‐CoV‐2 Omicron variant: A next phase of the COVID‐19 pandemic and a call to arms for system sciences and precision medicinePerspective Published on 2022-02-112022-10-30 Journal: MedComm [Category] COVID-19, [키워드] 3D models Arm artificial B.1.1.529 continuous variation coronavirus disease correlated COVID‐19 COVID‐19 infection Defense delta variant diagnose diagnostics Efficiency exhibited Health health systems high mortality Hospitalization in vitro Infection intelligence introduced mechanism mutated Mutation mutations nanomedicine natural immunity omicron pandemic Pathogenesis Perspective Precision precision medicine provided receptor‐binding domain recommendation reservoirs Respiratory Coronavirus SARS‐CoV‐2 SARS‐CoV‐2 mutations severity Spread Structure subtype System the spike protein Vaccines variant variants viral infection virus VOCs World Health Organization [DOI] 10.1002/mco2.119 PMC 바로가기 [Article Type] Perspective
Activation of Immune System May Cause Pathophysiological Changes in the Myocardium of SARS-CoV-2 Infected Monkey Model면역 체계의 활성화는 SARS-CoV-2에 감염된 원숭이 모델의 심근에 병태생리학적 변화를 일으킬 수 있음Article Published on 2022-02-102022-09-11 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] ACE2 receptor acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus analyzed cardiovascular cause change characterized collagen collected contagious contagious disease contribute coronavirus COVID-19 COVID-19 patients damages disease disorder eosin fibrosis foci heart heart failure heart tissue hearts hematoxylin Hematoxylin and eosin hypertrophy immunohistochemical staining induce Infection inflammatory cell inflammatory cells inflammatory immune response interstitial lead Lymphocytes Macrophage macrophages majority Model Monkey Myocardial myocarditis Myocardium pathological change pathological changes perivascular positive progression Region respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe complications staining subsequent System T lymphocyte T lymphocytes the disease tissue tissue sample ventricular virus virus particle virus particles [DOI] 10.3390/cells11040611 PMC 바로가기 [Article Type] Article
Evaluation of Betacoronavirus OC43 and SARS-CoV-2 Elimination by Zefero Air Sanitizer Device in a Novel Laboratory Recirculation SystemArticle Published on 2022-02-082022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome aerosol air sanitization airborne disease viruses both viruses collected Concentration coronavirus COVID-19 Device disease effective Efficacy eliminated eliminating Elimination evaluated experimental system indicated Italy Laboratory novel OC43 plexiglass qRT-PCR Recirculation returned SARS-CoV-2 System treated Treatment Viral RNA virucidal virus virus decontamination Volume was determined [DOI] 10.3390/pathogens11020221 PMC 바로가기 [Article Type] Article
Prognostic accuracy of triage tools for adults with suspected COVID-19 in a prehospital setting: an observational cohort studyObservational Study Published on 2022-02-082022-10-04 Journal: Emergency medicine journal : EMJ [Category] MERS, 임상, [키워드] 95% CI Accuracy adverse outcome Algorithm ambulance service clinical decision Cohort conducted COVID-19 COVID-19 infection death Emergency emergency ambulance systems emergency care systems England FIVE hospital Humber IMPROVE NEWS2 Observational cohort study organ support Patient populations predict Primary outcome respiratory Result risk Risk management score sensitivity service specificity System threshold transfer transported Triage WHO [DOI] 10.1136/emermed-2021-211934 PMC 바로가기 [Article Type] Observational Study
Hospital factor and prognosis of COVID-19 in New York City, the United States of America: insights from a retrospective cohort studyResearch Published on 2022-02-082022-10-28 Journal: BMC health services research [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] 95% confidence interval adjust Analysis baseline characteristics Brooklyn cohort study Community community hospital Coronavirus disease 2019 COVID-19 death rate Factor hazard ratio hospital Hospital factor hospitalized patient hospitals Laboratory Manhattan medical record Mortality Mount Sinai New York City pandemic Patient patients presenting Probability Prognosis Propensity score Result retrospective cohort study supplementary material System Teaching hospital the United State transfer transferred Treatment was performed Weighting [DOI] 10.1186/s12913-022-07570-w PMC 바로가기 [Article Type] Research
Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patientsObservational Study Published on 2022-02-072022-10-04 Journal: World journal of gastroenterology [Category] 임상, [키워드] abnormality acute respiratory syndrome adjusted Admission alanine aminotransferase albumin level alkaline phosphatase ALP ALT Asian Aspartate aminotransferase association AST Baltimore Bilirubin bilirubin. can be used Clinical characteristics Clinical outcome collected coronavirus COVID-19 COVID-19 patient COVID-19 severity Cox regression Cox regression analysis demographic disease severity drugs elevated Factor highest Hospital admission Hospitalization Hospitalized hospitalized patient in-hospital mortality Johns Hopkin Laboratory liver Liver injury Liver tests Measures mechanical ventilation mortality risk obesity Older age Other outcome Patient patients patients with COVID-19 predict Prevalence prevalent Prognosis retrospective risk serum severe acute respiratory syndrome coronavirus 2 severity severity and prognosis severity of COVID-19 System the patient therapy total bilirubin Treatment United States variable was used with COVID-19 [DOI] 10.3748/wjg.v28.i5.570 PMC 바로가기 [Article Type] Observational Study
COVID-19 hot-spot strategy: a special innovation in pandemic response, Oyo State NigeriaCovid-19 Hot-Spot 전략 : 유행성 반응의 특별 혁신, Oyo State NigeriaResearch Published on 2022-02-042022-09-10 Journal: BMC Public Health [Category] COVID19(2023년), Fulltext, MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Area average caused change Community confirmed cases Contact contributed coronavirus COVID-19 cross-sectional survey Data collection death Descriptive statistics facilitate focus Follow-up force help highest hotspot Hotspot strategy initiative implementation IMPROVE increase in index case information Intervention investigated Isolation local government management Measures mobile phones Nigeria North number of sample number of samples pandemic platform public health quarantine recorded respiratory response Result SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus shown state Surveillance System Task Force tested the disease Transmission Treatment turn was selected were recorded [DOI] 10.1186/s12889-022-12675-2 PMC 바로가기 [Article Type] Research
Comprehensive Analysis of the ILCs and Unconventional T Cells in Virus Infection: Profiling and Dynamics Associated with COVID-19 Disease for a Future Monitoring System and Therapeutic OpportunitiesReview Published on 2022-02-042022-10-31 Journal: Cells [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Activation adaptive Analysis Cell changes in clinical trials advanced therapies Cluster cohorts of patient Comprehensive comprehensive analysis COVID-19 COVID-19 affected patient Critical determine diagnostic Dynamics dysregulation Effect Express Factor Frequency function Future gamma-delta T cells highlight homeostasis Hospitalization ILC ILCs Immune status immune systems Infection innate lymphoid cell longitudinal study MAIT marker MONITOR monitoring NKT opportunity pathogenesis of COVID-19 profile Profiling prognostic biomarker question recovered patients SARS-COV-2 infection subjects Symptom System T cell Therapies therapy tissue Unconventional T cells viral respiratory pandemic with COVID-19 [DOI] 10.3390/cells11030542 PMC 바로가기 [Article Type] Review