Therapeutic strategies – Page 19 – Communicable Diseases Research

Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)

Immunology

Published on 2020-10-022022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Activation acute exacerbation acute respiratory distress Analysis ARDS autoantibodies autoantibody Autoimmune Autoimmunity clinical Clinical course collagen Computed tomography connective tissue connective tissue disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detection determine died disease ENA enrolled exacerbating Exacerbation feature fibroblast FIVE heterogeneous High-resolution histopathological finding Histopathology immunoblot immunofluorescence intensive care treatment Interstitial lung disease interstitial thickening investigated Laboratory testing mechanism objective Occurrence overlapping pathophysiology Patient Pneumonia positive predict Respiratory failure Result SARS-CoV-2 SARS-COV-2 infection serological severe complication severe COVID-19 significantly similarity syndrome the disease Therapeutic strategies tissue sample understanding was performed
[DOI] 10.3389/fimmu.2020.587517 PMC 바로가기 [Article Type] Immunology

Coronavirus in human diseases: Mechanisms and advances in clinical treatment

Review

Published on 2020-10-012022-10-30
Journal: MedComm [Category] COVID-19,

Clinically practiced and commercially viable nanobio engineered analytical methods for COVID-19 diagnosis

Research article

Published on 2020-10-012022-10-05
Journal: Biosensors & bioelectronics [Category] SARS, 유전자 메커니즘, 치료기술,

The role of host defences in Covid 19 and treatments thereof

Review

Published on 2020-09-292022-10-30
Journal: Molecular Medicine [Category] COVID-19,

[키워드] age ATP boost carbon monoxide catalytic activity cause Chloroquine circulating clinical manifestation clinically co-morbidity coding COVID 19 Critical distribution Donor Efficiency endothelial damage enveloped RNA virus event explain genetic trait growth Guidance heme oxygenase 1 hemoglobin HMOX1 Host hydrogen Hydrogen sulfide include Infection Inflammatory cytokines inhibit Interaction involved leucocyte lung infiltration mechanical ventilation mechanism modulate Paracetamol pathogenic mechanism predicted promoter Protein SARS-CoV-2 Sex shown survivor susceptibility therapeutic intervention Therapeutic strategies Treatment triggered variety
[DOI] 10.1186/s10020-020-00216-9 PMC 바로가기 [Article Type] Review

Severe COVID-19: what have we learned with the immunopathogenesis?

Review

Published on 2020-09-222022-10-28
Journal: Advances in Rheumatology (London, England) [Category] COVID-19, SARS,

Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena

Pharmacology

Published on 2020-09-172022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] absence acute respiratory syndrome Anti-inflammatory antibody antimalarial antiparasitic drug Antiviral arena available data benefit candidate Candidates caused cellular therapy China chloroquine/hydroxychloroquine city claimed clinical manifestation clinical trial clinically controls convalescent plasma coronavirus Coronavirus disease 2019 COVID-19 criteria cytokine drug Drug repurposing effective Epidemics evaluated Evidence explain Favipiravir global pandemic Guidance identify Immunotherapy imperative IMPROVE in vitro activity include Inconclusive initiation of treatment interferon investigational agent Ivermectin lack MERS Middle East monoclonal Natural killer cells observational study outcome outcomes pathology pathophysiology Patient patient selection Pneumonia Population Potential Potential treatment Prevent progression receptor Remdesivir Repurposed drug responsible SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 small sample size stem cell syndrome target the disease the patient the timing Therapeutic strategies therapeutic strategy therapy Treatment treatment guidelines umifenovir understanding Understood Vaccine virus Wuhan
[DOI] 10.3389/fphar.2020.585888 PMC 바로가기 [Article Type] Pharmacology

Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization

Brief Report

Published on 2020-08-302022-10-31
Journal: Membranes [Category] COVID-19,

SARS-CoV-2 meta-interactome suggests disease-specific, autoimmune pathophysiologies and therapeutic targets

SARS-CoV-2 메타 인터랙톰은 질병 특이적 자가면역 병태생리 및 치료 표적을 제시합니다

Research Article

Published on 2020-08-172022-09-11
Journal: F1000Research [Category] MERS, SARS, 신약개발,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed association Asthma asthma) Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity characterized Comorbidities Comorbidity condition contribute Coronary artery coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 Critical diabetes disease Diseases drug expression genetic background help Host human coronavirus human coronaviruses human lung humans identify IFN-β immunological pathway immunological pathways independent inflammatory state interferon interferons Intersection lung Lungs molecular interaction multiple comorbidities multiple comorbidity other respiratory virus Other respiratory viruses pathophysiology performed protein interaction protein-protein interaction reduced Regulation Regulatory repurposing respiratory SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 significant enrichment statistically significant Therapeutic strategies therapeutic strategy therapeutic target translate Treatment type 2 diabetes type I interferons virus viruses
[DOI] 10.12688/f1000research.25593.1 PMC 바로가기 [Article Type] Research Article

Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?

Microbiology

Published on 2020-08-132022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Evaluation of the Ion AmpliSeq SARS-CoV-2 Research Panel by Massive Parallel Sequencing

Article

Published on 2020-08-122022-10-31
Journal: Genes [Category] COVID-19, MERS,