The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for ComorbiditiesArticle Published on 2020-06-042022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] “cytokine storm” 229E acute respiratory syndrome alteration Betacoronavirus cause cell signalling pathways Comorbidities Consequences coronavirus Coronavirus-2 COVID-19 COVID-19 disease Critical database decrease effective exacerbated FIVE geographical region greater highest highlight host responses Human identify increased mortality Inflammatory response KEGG KEGG pathway KEGG pathway analysis Lung pathology mechanism MERS microRNAs (miRs 8066, 5197, 3611, 3934-3p, 1307-3p, 3691-3p, 1468-5p) miRNA Mutation number of comorbidities OC43 Pandemics pathogenicity pathway Phylogenetic relationship physiological effect prediction reduced reported response responses resulting SARS-CoV-2 SARS-CoV-2 sequence SARS–CoV-2 selected sequence sequence motif Seven Significant significant pathways similarity Symptom the SARS-CoV-2 Therapeutic approach transcriptional transcriptomic alteration viral pathogenesis viral pathogenicity virus viruses whole-genome [DOI] 10.3390/v12060614 PMC 바로가기 [Article Type] Article
Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptorsResearch Article Published on 2020-05-282022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] ACE2 airway ANPEP artificial intelligence association ciliated cell club cell coronavirus correlated COVID-19 COVID-19 pandemic DPP4 Enterocyte epithelial cells expression profiling Gut hotspot Human hypotheses knowledge machine learning maturation mechanism natural language processing olfactory Pathogenesis platform proteomics receptor reservoir RNA-Seq SARS-CoV-2 single cell RNA-seq Single-cell RNA-sequencing small intestine the SARS-CoV-2 tissue tongue transcriptional [DOI] 10.7554/eLife.58040 PMC 바로가기 [Article Type] Research Article
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients코로나19 환자에서 기관지폐포세척액과 말초혈액 단핵세포의 전사적 특성Article Published on 2020-03-312022-09-06 Journal: Emerging Microbes & Infections [Category] Communicable Disease, COVID-19, MERS, SARS, [키워드] Activation Anti-inflammatory Apoptosis association BALF Bronchoalveolar lavage fluid carried caused CCL2 CCL2/MCP-1 CCL3 CCL3/MIP-1A CCL4 CCL4/MIP1B Characteristics China country COVID-19 COVID-19 outbreak COVID-19 pathogenesis COVID-19 patient COVID-19 patients CXCL10 CXCL10/IP-10 cytokine cytokine release effort fatal disease Guidance HCoV highlight Host Host immune response host inflammatory response host response identify Infection Inflammation Inflammatory cytokine inflammatory cytokine profile IP-10 lymphocyte Lymphocytes lymphopenia medication molecular mononuclear cell mononuclear cells Mortality P53 signalling pathway Pathogenesis patients PBMC Peripheral blood Peripheral blood mononuclear cells public health RNA RNAs SARS-CoV-2 SARS-COV-2 infection Sequencing specimen therapeutic drug transcriptional Transcriptome transcriptome dataset transcriptome profiling transcriptome sequencing Treatment valuable resource [DOI] 10.1080/22221751.2020.1747363 PMC 바로가기 [Article Type] Article
Synergistic action of the transcription factors Krüppel homolog 1 and Hairy in juvenile hormone/Methoprene-tolerant-mediated gene-repression in the mosquito Aedes aegypti유년 호르몬에서 전사 인자 Krüppel homolog 1과 Hairy의 시너지 작용/모기 Aedes aegypti에서 메토프렌 내성 매개 유전자 억제Research Article Published on 2019-10-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition acting Activation addition adult females Aede assays binding binding site Blood co-regulated cohorts Complete complexity demonstrated downstream expression Factor Factors fat female function Gene Expression Genes Hairy hierarchy homolog hormone human diseases immature implicated information Insects Interaction Juvenile knockdown Krüppel luciferase maturation Methoprene Mosquito pathogen transmission pathway receptor regulate regulated Regulatory regulatory region reporter repressed repression reproduction reproductive required Research significantly stages subsequent synergistic synergistic action synergistic fashion target gene Target genes the mosquito transcription factor transcriptional transcriptional repressor transcriptomic analysis vector Zinc [DOI] 10.1371/journal.pgen.1008443 PMC 바로가기 [Article Type] Research Article
IFN-Lambda 3 Mediates Antiviral Protection Against Porcine Epidemic Diarrhea Virus by Inducing a Distinct Antiviral Transcript Profile in Porcine Intestinal EpitheliaImmunology Published on 2019-10-172022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] activate Against Analysis Antiviral antiviral activity Cell cellular processe Critical curtail differential expression elicit elicited enrichment analysis enteroids epidemic diarrhea epithelia epithelial expression gastrointestinal tract Genes IFN IFN-α IFN-λ IFN-λ1 indicated induce Inducing Infection inhibited Interferon alpha interferon-lambda 3 intestinal intestine ISG knowledge mechanism mucosal overlap PEDV previous study profile protection regulate reported responsible RNA-Seq robust RT-qPCR shown signaling pathway signaling pathways significantly transcription profile transcriptional transient expression Type type I Type I IFN unique viral infection virus virus infection [DOI] 10.3389/fimmu.2019.02394 PMC 바로가기 [Article Type] Immunology
Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice감수 분열 게이트 키퍼 STRA8은 생쥐의 정자 형성 동안 Nr1d1 발현을 억제하여자가 포식을 억제합니다Research Article Published on 2019-05-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition autophagy bind Cell cell cycles cells cellular chromosomal cohesion Critical demonstrated DNA double strand double strand break DSBs ectopic expression Effect expression Fertility function Genes Genetic genomic germ cells haploid gamete homolog hormone receptor inhibit male maturation meiosis meiotic mice mitotic molecular Nr1d1 nuclear organelle promoter Protein Recombination required retinoic acid sexual reproduction spermatogenesis STRA8 suppresse suppressor synapsis target gene Target genes Transcription transcriptional transition turn Ulk1 upregulated upregulation Vertebrate vertebrates [DOI] 10.1371/journal.pgen.1008084 PMC 바로가기 [Article Type] Research Article
The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C . elegans핵 호르몬 수용체 NHR-86은 C에서 항병원체 반응을 조절한다. 엘레강스Research Article Published on 2019-01-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation adaptive Analysis Author bacterial pathogen baseline bind biological function canonical characterized chromatin chromatin immunoprecipitation Control determine Drosophila effector elegan elegans exogenous ligands experiments family function Genetic genetic screen Genome homolog hormone receptor hormone receptors host response Human immune immune activation immunostimulatory induce Infection innate immune activation majority MAPK modulate nuclear pathogen pathway PMK-1 positioned promoter promoters Protective Protein provide Pseudomonas aeruginosa Recognition Regulation required response small molecule target Transcription transcription factor transcription factors transcriptional transcriptional regulator transcriptional response Transcriptome [DOI] 10.1371/journal.pgen.1007935 PMC 바로가기 [Article Type] Research Article
Overexpression of the nucleocapsid protein of Middle East respiratory syndrome coronavirus up-regulates CXCL10Research Articles Published on 2018-09-212022-10-28 Journal: Bioscience Reports [Category] Coronavirus, [키워드] A549 cells addition airway epithelial cell antiviral genes antiviral response cause cells cellular processe CXCL10 dendritic cells determine Factor fibroblast cells Genes high mortality rate Host Human IL6 IL8 independent infected cell Infection interactions knowledge lung MERS-CoV Middle East Middle East respiratory syndrome Coronavirus monoclonal antibody monocyte-derived macrophage motif murine N-terminal domain nucleocapsid nucleocapsid protein overexpressed overexpression Patient PCR Protein regulate regulated reported residue Respiratory disease respiratory syndrome coronavirus secretion selected Severity of disease TNF transcriptional transcriptionally transiently transfected translational up-regulate up-regulated was used [DOI] 10.1042/BSR20181059 PMC 바로가기 [Article Type] Research Articles
Complexin in ivermectin resistance in body lice몸니의 이버멕틴 저항성에 있는 콤플렉스Research Article Published on 2018-08-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis animals association cDNA changes complexin correlation differentially expressed downregulated Effect evaluated Evidence expression helminthic disease helminthic diseases Human induce insecticide Interference involved Ivermectin knocking down Laboratory loci mechanism mRNA Mutation mutations neuronal nonsense mutation other infestations pediculicide premature stop codon Protein protein level Proteins proteome proteomic Proteomic analysis qRT-PCR regulated reported searched shown significantly susceptible transcript transcriptional unique upregulated Variation [DOI] 10.1371/journal.pgen.1007569 PMC 바로가기 [Article Type] Research Article
Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network비평형 억제인자 결합 동역학은 SOS 유전자 네트워크 내에서 DNA 손상 용량을 전사 타이밍에 연결합니다Research Article Published on 2018-06-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activity bacterial DNA best binding binding interaction binding kinetics Biochemical pathways cause Cell cellular Concentration Critical defined Degradation disequilibrium DNA binding DNA damage DNA damage repair pathway DNA damaging dose drop Escherichia coli expression Gene Expression Genes kinetic leads LexA low dose mechanism modulate network operator operators pathway Physiology promoter promoters rapid equilibrium assumptions regulate regulated Regulatory respond resulting reveal separated SOS gene SOS pathway SOS response subset the cell the timing These data Transcription transcription factor transcription regulation transcriptional transcriptional repressor Trigger triggers [DOI] 10.1371/journal.pgen.1007405 PMC 바로가기 [Article Type] Research Article