A genetic variant in IL-6 lowering its expression is protective for critical patients with COVID-19발현을 낮추는 IL-6의 유전적 변이는 COVID-19에 걸린 중요한 환자를 보호합니다Article Published on 2022-04-022022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] Analysis association Asymptomatic COVID-19 changes in Chinese Cohort Control coronavirus disease Coronavirus disease 2019 COVID-19 Critical critical condition expression Factor Formal G allele Genetic genetic factors Genetic variant Genome-wide association study genome-wide significance genome-wide significant Genotype healthy control healthy controls high mortality identify IL-6 IL-6 expression in vitro involved luciferase luciferase expression male Patient patients with asymptomatic patients with COVID-19 performed PROTECT Protective recruited replicated reported responsible serum significantly surpassed threshold variant Variation with COVID-19 [DOI] 10.1038/s41392-022-00923-1 PMC 바로가기 [Article Type] Article
Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study영국에서 SARS-CoV-2 오미크론(B.1.1.529) 및 델타(B.1.617.2) 변이와 관련된 입원 및 사망 위험 비교 분석: 코호트 연구Article Published on 2022-04-022022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI adjusted adjusted hazard ratio Admission affected age Analysis B.1.1.529 B.1.617.2 booster booster vaccination Cohort cohort study Comparative analysis Council COVID-19 case dataset death decile delta variant demonstrated Department Deprivation dose doses Effectiveness Endpoint Engineering England estimate Ethnicity Evidence evidence of examined hazard hospital Hospital admission hospitalisation index individuals Infection infections Innovation intrinsic laboratory-confirmed maintain Medical Research Council moderate Mortality mRNA vaccine mRNA vaccines National offered omicron Omicron variant outcome primary analysis Protective provided reduction reduction in Relative risk resulting risk SARS-CoV-2 SARS-COV-2 infection Science severity Severity of infection Sex stratified the vaccine Transmissibility vaccinated individual vaccinated individuals vaccination Vaccination Status Vaccine variant variants Variation [DOI] 10.1016/S0140-6736(22)00462-7 PMC 바로가기 [Article Type] Article
Observational study on chest pain during the Covid-19 pandemic: changes and characteristics of visits to a Norwegian emergency department during the lockdownObservational Study Published on 2022-04-022022-10-04 Journal: BMC Emergency Medicine [Category] 임상, [키워드] Acute coronary syndrome age average change Characteristics chest pain collected COVID-19 Emergency emergency services Fewer patient Gender hospital impacted increase in initial IQR less lockdown moderate Myocardial infarction National normalized Norway Norway. observational study outbreak pandemic Patient patients presenting proportion remained severity Spread study period subsequent the median the patient Variation [DOI] 10.1186/s12873-022-00612-w PMC 바로가기 [Article Type] Observational Study
Rapid and sensitive detection of SARS-CoV-2 variants in nasopharyngeal swabs and wastewaters비인두 면봉 및 폐수에서 SARS-CoV-2 변이체의 신속하고 민감한 검출Article Published on 2022-04-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Affect allelic appearance carried characterized clade clades containment strategies detect diffusion disease severity Effectiveness Evolution functional genomic genotypes Genotyping assay help host immunity house Interaction limit mutations Nasopharyngeal swab nasopharyngeal swabs new SARS-CoV-2 NGS poor quality Rapid SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Spread tested urgency variant Variation variations viral genome virus Virus evolution VOCs wastewater whole-genome sequencing [DOI] 10.1016/j.diagmicrobio.2021.115632 PMC 바로가기 [Article Type] Article
Integrated autolysis, DNA hydrolysis and precipitation enables an improved bioprocess for Q-Griffithsin, a broad-spectrum antiviral and clinical-stage anti-COVID-19 candidateResearch article Published on 2022-04-012022-10-05 Journal: Biochemical Engineering Journal [Category] 임상, 치료제, [키워드] anticipated Antiviral autolysis Biologics manufacturing Broad spectrum antiviral cellular clinical trial Complete contaminant COVID-19 COVID-19 pandemic DNA downstream Downstream recovery E. coli Efficiency endotoxin equipment feature fixed flexible griffithsin host cell hydrolysis IMPROVE membrane Modification nucleic acids pandemic performed produced Protein purified reducing Variation vessel [DOI] 10.1016/j.bej.2022.108403 [Article Type] Research article
Emerging of composition variations of SARS-CoV-2 spike protein and human ACE2 contribute to the level of infection: in silico approachesSARS-CoV-2 스파이크 단백질과 인간 ACE2의 조성 변화가 감염 수준에 기여함: in silico 접근법Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 angiotensin bind binding affinity binds bioinformatics calculated Combination contribute COVID-19 detect determine docking domain eight FIVE Genetic variant global energy hACE2 human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in silico in silico Approach in silico software Interaction investigated Laboratory moderate NCBI nsSNPs pandemic pathogenic PPI processed Protein Protein docking protein-protein interaction RBD RBD variant RBD variants Receptor-binding domain retrieved risk of infection SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein sequence similarity significantly SNP SNPs Support the binding affinity V367F V483A variant variants Variation zone [DOI] 10.1080/07391102.2020.1841032 PMC 바로가기 [Article Type] Article
Establishing reference sequences for each clade of SARS-CoV-2 to provide a basis for virus variation and function research바이러스 변이 및 기능 연구의 기반을 제공하기 위해 SARS-CoV-2의 각 clade에 대한 참조 염기서열 설정Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accumulate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition analyses Analysis Antiviral strategies antiviral strategy caused Characteristics characterizing mutation clade clades coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic defined distribution effective Establishing facilitate faster Genome Genotype Geographic distribution GISAID greater high-frequency mutation homology homology analysis less lowest molecular Mutation mutation rate reference sequence Research respiratory Respiratory disease SARS-CoV-2 severe respiratory disease USA Vaccine Variation variation analyses. virus virus spread [DOI] 10.1002/jmv.27476 PMC 바로가기 [Article Type] Article
Trends In Outpatient Mental Health Services Use Before And During The COVID-19 PandemicObservational Study Published on 2022-04-012022-10-04 Journal: Health affairs (Project Hope) [Category] 임상, [키워드] accounted age Analysis Anxiety average Care COVID-19 COVID-19 pandemic current Diagnosis disorder groups highlight implication in-person visit mental health mental health condition mental health service office Older Outpatient pandemic proportion reduced retrospective Schizophrenia service trend Variation [DOI] 10.1377/hlthaff.2021.01297 PMC 바로가기 [Article Type] Observational Study
Differences and Similarities Among COVID-19 Patients Treated in Seven ICUs in Three Countries Within One Region: An Observational Cohort StudyObservational Study Published on 2022-04-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] Admission admitted to ICU age Analysis applied approval assessment Belgium Characteristics chronic Clinical characteristics Comorbidities complications coronavirus disease COVID-19 COVID-19 patient criteria Descriptive statistics Diagnosis difference disease severity driver European failure female Frequency Genetic Germany healthcare Healthcare system ICU independent interfere International Laboratory Logistic regression measurement Mortality mortality rate Netherlands Observational cohort study organ support outcome pandemic Patient patient group performed Physiology retrieved Sex significantly Support supported Therapies therapy variance Variation [DOI] 10.1097/CCM.0000000000005314 PMC 바로가기 [Article Type] Observational Study
An in-depth statistical analysis of the COVID-19 pandemic’s initial spread in the WHO African regionWHO 아프리카 지역에서 COVID-19 전염병의 초기 확산에 대한 심층 통계 분석Article Published on 2022-04-012022-09-11 Journal: BMJ Global Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] African attack rate attack rates case fatality ratio CFR Containment measure country COVID-19 COVID-19 pandemic cross-sectional cross-sectional study cross-sectional survey cumulative death described driver effective Epidemic Epidemiology First wave FIVE Government greater growth Growth period Health implementation initial mathematical Mathematical modelling member Older pandemic populations predictor variable public health reduction regression analysis Resilience SARS-COV-2 infection SARS-CoV-2 infections severity Spread stability state statistical analysis Surveillance tested the WHO threat Variation virus WHO [DOI] 10.1136/bmjgh-2021-007295 PMC 바로가기 [Article Type] Article