Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection
무료 SARS-CoV-2 스파이크 단백질 S1 입자는 COVID-19 감염의 병인에서 역할을 할 수 있습니다
Hypothesis
[키워드] accompanied
ACE
ACE2
angiotensin
angiotensin (1-7)
Angiotensin II
Angiotensin-converting enzyme
angiotensin-converting enzyme 2
association
caused
Cell
cell surface
circulation
cleavage site
COVID-19
COVID-19 disease
COVID-19 infection
COVID-19 pathogenesis
D614G
D614G mutation
decrease
disease
downregulate
downregulated
Effect
expression
fraction
Free
furin
furin protease
higher infectivity
Hypothesis
Imbalance
in vivo
infected cell
infected cells
Infection
Inflammation
investigated
lack
lead
less
lung
Lungs
membrane-bound
murine model
mutant
natural infection
Particle
Pathogenesis
pathogenesis of COVID-19
Prevalence
Protein
pulmonary damage
receptor-binding domains
Recombinant spike protein
Renin
renin-angiotensin system
reported
role
S protein
S1 and S2
S1 subunit
S1 subunit shedding
SARS-CoV virus
SARS-CoV-2
SARS-CoV-2 S protein
SARS-CoV-2 strain
separation
severity
shown
spike
Spike protein
subunits
the cell
the receptor-binding domain
the S protein
the S1 subunit
the SARS-CoV-2
thrombosis
trimer
unlikely
Viral
Viral load
virion
virions
wild type
[DOI] 10.1134/S0006297921030032 PMC 바로가기 [Article Type] Hypothesis
[DOI] 10.1134/S0006297921030032 PMC 바로가기 [Article Type] Hypothesis