Impact of COVID-19 on women and children and the need for a gendered approach in vaccine developmentCOVID-19가 여성과 어린이에 미치는 영향과 백신 개발에서 성별 접근의 필요성Review Published on 2020-12-012022-08-31 Journal: Human vaccines & immunotherapeutics [Category] MERS, 신약개발, [키워드] approach child health child health services children clinical trial clinical trials COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines disrupting Emergency gendered approach Health Health services Impact implementation Inclusion lactating morbidity Mortality mother Newborn pandemic pregnant pregnant women public health reproductive Taking the times Vaccine Vaccine development women women and child health. [DOI] 10.1080/21645515.2020.1826249 PMC 바로가기 [Article Type] Review
Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID)Clinical Trial Published on 2020-12-012022-10-05 Journal: Thrombosis research [Category] 임상, [키워드] activated partial thromboplastin time acute respiratory distress syndrome Anticoagulant Anticoagulant treatment anticoagulation aPTTactivated partial thromboplastin time ARDSacute respiratory distress syndrome assigned autopsy study baseline BMIbody mass index body mass index cause Chronic Kidney Disease Epidemiology Collaboration CIconfidence interval circulation CKD-EPIChronic Kidney Disease Epidemiology Collaboration clinical trial Coagulopathy confidence interval Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19coronavirus disease 2019 CrClcreatinine clearance creatinine clearance D-dimer decrease DICdisseminated intravascular coagulation Disseminated intravascular coagulation evaluated FiO2 FiO2fraction of inspired oxygen fraction fraction of inspired oxygen Gas exchange hypercoagulable ICUIntensive Care Unit IMPROVE increase in intensive care unit interquartile range IQR IQRinterquartile range LMWHlow molecular weight heparin low molecular weight heparin Mechanical mechanical ventilation microthrombi observé Open-label oxygen PaO2 PaO2/FiO2 ratio PaO2partial pressure of arterial oxygen partial pressure of arterial oxygen Patient PEEPpositive end-expiratory pressure Positive end-expiratory pressure Prophylactic randomization Randomized receive reverse transcriptase-polymerase chain reaction RT-PCRreverse transcriptase-polymerase chain reaction SAPS3simplified acute physiology score 3 sepsis-induced coagulopathy score sequential organ failure assessment score severe COVID-19 SICsepsis-induced coagulopathy score simplified acute physiology score 3 SOFAsequential organ failure assessment score statistically significant therapeutic Thromboprophylaxis UFHunfractionated heparin ULNupper limit of normal unfractionated heparin upper limit of normal Ventilation ventilator-free day Ventilator-free days [DOI] 10.1016/j.thromres.2020.09.026 PMC 바로가기 [Article Type] Clinical Trial
Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium유럽의 소아 초기 암 임상 시험에서 COVID-19의 영향: 암이 있는 어린이를 위한 혁신적 치료(ITCC) 컨소시엄의 보고서Article Published on 2020-12-012022-08-31 Journal: European journal of cancer (Oxford, England : 1990 [Category] MERS, SARS, 신약개발, 임상, [키워드] activities addition affected analysed assessment Cancer challenge changes clinical Clinical research clinical trial clinical trials country COVID-19 COVID-19 pandemic drug Drug development Europe Haematology Healthcare policy hospital Identified Impact legal aspects Local molecular MOST oncology Paediatric haematology and oncology. participated Patient Patient care patient recruitment Phase I platform question recruitment reduction in reported Research resource reveal site initiation suffered supply Trial [DOI] 10.1016/j.ejca.2020.09.024 PMC 바로가기 [Article Type] Article
Favipiravir-induced fever in coronavirus disease 2019: A report of two cases코로나바이러스 질환 2019에서 파비피라비르 유발 발열: 2건의 보고Case Reports Published on 2020-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료제, [키워드] administration Antiviral antiviral agent best clinical trial clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients drug drug fever Favipiravir Fever improvement Improvements knowledge laboratory investigation Novel coronavirus novel coronavirus disease Patient Physical examination Pyrexia symptoms of COVID-19 [DOI] 10.1016/j.ijid.2020.09.1450 PMC 바로가기 [Article Type] Case Reports
Can BCG be useful to mitigate the COVID-19 pandemic? A Canadian perspectiveBCG가 COVID-19 전염병을 완화하는 데 유용할 수 있습니까? 캐나다인의 관점Article Published on 2020-12-012022-09-11 Journal: Canadian Journal of Public Health = Revue Canadien [Category] 비임상, 임상, [키워드] association Bacillus Calmette-Guérin BCG BCG vaccination Bladder cancer breath Can Canada Cancer case-control study clinical trial Community coronavirus COVID-19 ecological Ecological studies Efficacy English Evidence expected French Frequency health authorities Hypothesis Immunity immunization in vitro indication individual Infection initiated Innate Innate immunity Interpretation mitigate mycobacteria outbreak past pathogen Pathogens Perspective phase Population processus public health authorities Research SARS-CoV-2 SARS-COV-2 infection Scientific community severity of COVID-19 SRAS-CoV-2 subject suggested trained immunity Treatment vaccination Vaccine vulnerable population widespread [DOI] 10.17269/s41997-020-00439-7 PMC 바로가기 [Article Type] Article
Neutralizing antibodies for the treatment of COVID-19COVID-19 치료를 위한 중화 항체Article Published on 2020-12-012022-09-12 Journal: Nature biomedical engineering [Category] MERS, SARS, 신약개발, 임상, 진단, 치료법, [키워드] antibody clinical trial COVID-19 determine neutralizing monoclonal antibody Patient populations Prevent reduce SARS-CoV-2 antigen sera severity the disease Treatment [DOI] 10.1038/s41551-020-00660-2 PMC 바로가기 [Article Type] Article
Causal inference methods for small non-randomized studies: Methods and an application in COVID-19소규모 비무작위 연구를 위한 인과 추론 방법: COVID-19의 방법 및 적용Article Published on 2020-12-012022-09-11 Journal: Contemporary clinical trials [Category] SARS, 임상, 치료제, [키워드] Analysis applied approach Causal Causal inference Clinical studies clinical trial Conditioning covariates COVID-19 diagnostics Efficacy Hydroxychloroquine include less limitation non-randomized non-randomized studies Open-label Pandemics patients with COVID-19 pressure Propensity score provided R code Randomized controlled trial reduce replicate risk robust SARS-CoV-2 pandemic Small samples. Treatment trials Vaccines Variation [DOI] 10.1016/j.cct.2020.106213 PMC 바로가기 [Article Type] Article
Anticoagulation in COVID-19: Effect of Enoxaparin, Heparin, and Apixaban on MortalityCOVID-19의 항응고: Enoxaparin, Heparin 및 Apixaban이 사망률에 미치는 영향Article Published on 2020-12-012022-09-11 Journal: Thrombosis and haemostasis [Category] SARS, 바이오마커, [키워드] 2019 48 hour 48 hours adjusted Admission age Analysis analyzed Anticoagulant Anticoagulants anticoagulation anticoagulation therapy apixaban benefit categories clinical trial cohort study Comorbidity coronavirus coronavirus disease COVID-19 D-dimer D-dimer level D-dimer levels decrease decreased mortality demonstrated disease disease severity Effect Efficacy enoxaparin entire cohort filtration rate Gender glomerular filtration rate heparin Hospitalization Illness severity IMPROVE increased mortality Increases increases in Inpatients intensive care intensive care unit admission intention-to-treat Logistic regression Logistic regression analyses Mortality no increase Odds ratio oxygen oxygen saturation parameters Patient patients with moderate Prophylactic prothrombotic significant decrease stratified survival therapy Ventilation [DOI] 10.1055/s-0040-1720978 PMC 바로가기 [Article Type] Article
IDentif . AI : Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐Cov‐2) with digital drug developmentResearch Report Published on 2020-12-012022-10-27 Journal: Bioengineering & Translational Medicine [Category] COVID-19, [키워드] acute respiratory syndrome approach artificial intelligence clinical trial clinically collected Combination combination therapy combinatory treatment coronavirus coronavirus 2 COVID‐19 Digital medicine dosages drug combination Drug development drug interaction Drug interactions Efficacy experimental validation Hydroxychloroquine in vitro Infectious disease Live virus magnitude Outbreaks outcome outcomes overcome Patient platform reduction in Remdesivir representing respiratory Ritonavir SARS‐CoV‐2 SARS‐CoV‐2 therapy trials [DOI] 10.1002/btm2.10196 PMC 바로가기 [Article Type] Research Report
Is Machine Learning a Better Way to Identify COVID-19 Patients Who Might Benefit from Hydroxychloroquine Treatment?—The IDENTIFY TrialArticle Published on 2020-11-262022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval adjusted hazard ratio Algorithm approach association benefit Better clinical trial competing conducted COVID-19 COVID-19 patient discharge drug treatment Endpoint enrolled Evidence General population hazard hospitals Hydroxychloroquine hydroxychloroquine treatment identify increase in indicated machine learning Mortality novel coronavirus disease outcome Patient Pragmatic prediction Randomized SARS-CoV-2 statistically significant subpopulation survival therapeutic agent treated Treatment Trial United State [DOI] 10.3390/jcm9123834 PMC 바로가기 [Article Type] Article