A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness관련성 전체 스펙트럼에 걸친 일배체형 단계에 대한 일반적인 접근 방식Research Article Published on 2014-04-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy allele alleles approach association can be used chance chromosome Cohort cohorts correction detect disease downstream analyses error rate explicit Genetic Genetic studies genetics Genotype genotyped individuals genotypes genotyping Haplotype haplotypes IBD individual individuals information investigated isolates Merlin much lower parents Phenotypes Population populations provide Recombination recombination event researcher sequence Spectrum [DOI] 10.1371/journal.pgen.1004234 PMC 바로가기 [Article Type] Research Article
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6 , a Gene Identified through Mining the DPH1 – DPH5 Interaction Network효모에서 디프타마이드 생합성의 아미드화 단계에는 DPH1 - DPH5 상호작용 네트워크 마이닝을 통해 확인된 유전자인 DPH6이 필요합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy adenine adenine nucleotide ADP Affect agent amidase Amino acid approach association ATP Author bind Biosynthesis biosynthetic biosynthetic pathway candidate candidate gene Cell cell growth characterized check Complete completion component components Corynebacterium diphtheriae defined Diphthamide dissociation domain DPH1 Dph5 Dph6 Dph7 eEF2 elongation factor embryogenesis enzyme evade expected failure Final form found generate Genes Genetic genetic interaction genomic growth histidine Identified identify inactivation indicated inhibitor inhibitors initial Interaction involved Like maintain mass spectrometry mice molecular mutant name network nucleotide observation pathogen pathway produced promote Protein protein synthesis Proteins Regulatory required residue response Saccharomyces cerevisiae step target trait translation translational upregulated [DOI] 10.1371/journal.pgen.1003334 PMC 바로가기 [Article Type] Research Article
Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence주요 대립 유전자 참조 서열을 사용한 가족 4중주에서의 단계적 전체 게놈 유전적 위험Research Article Published on 2011-09-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy allele Analysis approach Author base pairs base pairs) Blood blood clot characterization coding compound heterozygosity contribute contributing to demonstrated develop disease disease risk disease-associated estimation facilitate family Gene genetic determinant genetic determinants genetic information genetic profile genetic risk genetic risk factor genetic risk factors Genetic variation Genome genomes Genotype Haplotype Human human leukocyte antigen identify Interpretation leukocyte loci lowest lung Major median medications methodology nuclear nuclear family occur pharmacological predisposition Pulmonary embolism quantification Quartet Recombination reference reference sequence risk Risk assessment risk for disease sequence Sequencing sequencing error sequencing errors therapy Thrombophilia variant whole-genome sequencing [DOI] 10.1371/journal.pgen.1002280 PMC 바로가기 [Article Type] Research Article
Assessment of Parental Report for 2009–2010 Seasonal and Monovalent H1N1 Influenza Vaccines among Children in the Emergency Department or HospitalArticle Published on 2011-09-022023-06-09 Journal: Academic pediatrics [Category] 신종인플루엔자, [키워드] Accuracy Child influenza vaccine monovalent H1N1 influenza vaccine parental report seasonal influenza vaccine Validity [DOI] 10.1016/j.acap.2011.08.006 PMC 바로가기 [Article Type] Article
Improved microarray gene expression profiling of virus-infected cells after removal of viral RNAMethodology Article Published on 2008-05-142022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Accuracy acquisition alteration analyses conditions coronavirus detect different False-positive Gene Expression Gene expression profiling host cell IMPROVE Improved infected cell Infection interfere investigated mean Microarray microarray analysis Microarrays reduced reliability Result RNA RNAs sensitivity significantly tested total RNA Viral RNA virus-infected cell vRNA [DOI] 10.1186/1471-2164-9-221 PMC 바로가기 [Article Type] Methodology Article