clinical trial – Page 193 – Communicable Diseases Research

Sex differences in COVID-19: the role of androgens in disease severity and progression

COVID-19의 성별 차이: 질병 중증도 및 진행에서 안드로겐의 역할

Review

Published on 2020-11-112022-09-10
Journal: Endocrine [Category] MERS, SARS, 변종,

Efficacy and safety of sofosbuvir/ ledipasvir in treatment of patients with COVID-19; A randomized clinical trial

COVID-19 환자 치료에서 소포스부비르/레디파스비르의 효능 및 안전성; 무작위 임상 시험

Randomized Controlled Trial

Published on 2020-11-102022-09-11
Journal: Acta bio-medica : Atenei Parmensis [Category] 임상, 치료제,

[키워드] accelerated adverse effect adverse effects adverse event assigned Care clinical clinical response clinical trial clinical trials comparable control group Course COVID-19 diarrhea drug discontinuation Efficacy and safety event faster Gastrointestinal Gastrointestinal events group groups hospital Hospitalization ICU Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 Mortality mortality rate Most patients nausea not different occurred Open-label Patient patients provided randomized clinical trial receive Sample size Side effect Standard of care time transferred Treatment treatment of COVID-19 vomiting vomiting and diarrhea were assessed
[DOI] 10.23750/abm.v91i4.10877 PMC 바로가기 [Article Type] Randomized Controlled Trial

NP213 (Novexatin®): A unique therapy candidate for onychomycosis with a differentiated safety and efficacy profile

NP213 (Novexatin®): 차별화된 안전성과 효능 프로필을 가진 손발톱진균증을 위한 독특한 치료 후보

Article

Published on 2020-11-102024-08-17
Journal: Medical Mycology [Category] 백선증,

[키워드] Antifungal antimicrobial peptide clinical trial Dermatophyte Onychomycosis tinea

Comparative effectiveness and safety of antiviral agents for patients with COVID-19: Protocol for a systematic review and individual-patient data network meta-analysis

Registered Report Protocol

Published on 2020-11-092022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

COVID-19 infection: Disease detection and mobile technology

Global Health

Published on 2020-11-092022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] 2019-nCoV acute respiratory syndrome affected article center China Chinese clinical trial community transmission Control coronavirus coronavirus disease country COVID-19 disease disease spread disease transmission Epidemiology etiology IMPROVE include literature review mitigate Mobile Mobile technology Nanotechnology Nature novel beta-coronavirus outbreak pandemic performed Pneumonia potential treatments Precaution prevention promote PROTECT provide reduce responsible Result SARS-CoV-2 SARS-CoV2 Self-isolation social distancing Spread took place Treatment Vaccine wearing face mask World Health Organization Wuhan
[DOI] 10.7717/peerj.10345 PMC 바로가기 [Article Type] Global Health

Monitor for COVID-19 vaccine resistance evolution during clinical trials

Perspective

Published on 2020-11-092022-10-28
Journal: PLoS Biology [Category] COVID-19, SARS,

[키워드] approach candidate vaccine clinical trial clinical trials collected COVID-19 vaccine COVID-19 vaccines drug resistance Evolution information less question Safe Vaccine
[DOI] 10.1371/journal.pbio.3001000 PMC 바로가기 [Article Type] Perspective

Efficacy and efficiency of a new therapeutic approach based on activity-oriented proprioceptive antiedema therapy (TAPA) for edema reduction and improved occupational performance in the rehabilitation of breast cancer-related arm lymphedema in women: a controlled, randomized clinical trial

Study Protocol

Published on 2020-11-092022-10-28
Journal: BMC Cancer [Category] COVID-19,

[키워드] activity Activity-oriented proprioceptive antiedema therapy (TAPA in Spanish) added addition affected Analysis ARMS blind Breast Breast cancer Breast cancer (BC) - lymphedema (L) Cancer Care clinical trial clinical variable collected Complex decongestive therapy (CDT) component Consensus control group Controlled COVID-19 pandemic current Date develop dosage edema effective Efficacy Efficiency Evidence experimental group FIVE Health-related quality of life (HRQoL) individual Intervention lack limitation Occupational therapy (OT) Patient performed preventive measures promote proprioceptive public health randomized clinical trial reached reduction Registered rehabilitation Research Result Stage stage I stage II Stratification Therapeutic approach therapy treat treated Treatment Trial Volume women
[DOI] 10.1186/s12885-020-07558-x PMC 바로가기 [Article Type] Study Protocol

Efficacy and safety of anti-hepatic fibrosis drugs

Review

Published on 2020-11-072023-06-12
Journal: World journal of gastroenterology [Category] B형 간염,

[키워드] antifibrotic cirrhosis clinical trial fibrosis liver pharmacotherapy Safety
[DOI] 10.3748/wjg.v26.i41.6304 PMC 바로가기 [Article Type] Review

Recent Advances in Pathophysiology, Drug Development and Future Perspectives of SARS-CoV-2

Cell and Developmental Biology

Published on 2020-11-062022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] ACE2 acute respiratory distress addition advance Affect angiotensin-converting enzyme-2 bind Clinical data clinical trial complications Computed tomography conducted convalescent coronavirus develop development Diagnosis disease Disseminated intravascular coagulation drug Drug discovery effective Epidemic Epidemiology evaluated Future health worker highly pathogenic identify IgG antibody IgM immune response include infiltration intestinal epithelial cells lymphocytic myocarditis management pandemic Pathogenesis pathophysiology Patient care patients Perspective Pneumonia public health quantitative reverse-transcription PCR recent receptor recognize researcher SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 pneumonia shown Spike protein the disease the SARS-CoV-2 Transmission Treatment upper respiratory tract Vaccine Vaccine development
[DOI] 10.3389/fcell.2020.580202 PMC 바로가기 [Article Type] Cell and Developmental Biology

Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approach

Article

Published on 2020-11-052022-10-04
Journal: Scientific Reports [Category] 신약개발, 임상, 진단, 치료제,

[키워드] 3CLpro active against addition adopted approach AutoDock baloxavir marboxil bind binding binding affinity binding energy binding free energy clinical trial Compound coronavirus crystal structure darunavir database death dihydroergotamine Drug discovery drug trials drugs healthcare help homology host cell identify Infection inhibit lack Lonafarnib Medicinal chemistry molecular Nilotinib outbreak pandemic Papain-like protease phthalocyanine PLPro protease Protein RdRP reached reported Research RNA-dependent RNA polymerase SARS-CoV-2 screened Spike protein Spread Structure Tadalafil target targets Theoretical chemistry these compounds Treatment viral infection virus
[DOI] 10.1038/s41598-020-75762-7 PMC 바로가기 [Article Type] Article