Transplantation of Mesenchymal Stem Cells: A Potential Adjuvant Therapy for COVID-19Bioengineering and Biotechnology Published on 2020-11-052022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] acute respiratory syndrome adjuvant ALI/ARDS anti-apoptotic Anti-inflammation Anti-inflammatory antiviral agent approved causative pathogen clinical trial clinical trials coronavirus Coronavirus-2 COVID-19 Cytokine storm Effect Efficacy immunomodulation immunomodulatory mechanisms mesenchymal stem cell Mesenchymal stem cells MSC MSCs Pathogenesis Potential provide public health threat regenerative effect Research Safe SARS-CoV-2 STEM therapeutic effect therapeutic strategy therapy transplantation Treatment Vaccine virus infection [DOI] 10.3389/fbioe.2020.557652 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Antibody-Based Immunotherapeutic Strategies for COVID-19Review Published on 2020-11-052022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acting addition antibodies antibody boost clinical trial clinical trials convalescent plasma coronavirus COVID-19 effective effort highlight Host immune defense immune system immunomodulatory Immunotherapy include mechanism monoclonal antibody NAbs neutralizing antibody Passive Prophylaxis Registered SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Strategy therapy Treatment Vaccine [DOI] 10.3390/pathogens9110917 PMC 바로가기 [Article Type] Review
Cardiac adverse events associated with chloroquine and hydroxychloroquine exposure in 20 years of drug safety surveillance reportsArticle Published on 2020-11-052022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] addition advanced age Adverse adverse effects adverse event analyzed Antimicrobial therapy association Autoimmune diseases cardiac Cardiac complications cardiovascular diseases Chloroquine clinical trial confounding factors contributing to COVID-19 COVID-19 complication diagnose disorders drug drug therapy Essential food HCQ Health care help higher risk hospital Hydroxychloroquine increased mortality Infectious diseases list malaria Male sex off-label Patient public health Reporting rheumatoid arthritis SARS-COV-2 infection Side effect Side effects SLE Surveillance System systemic lupus erythematosus the United State therapeutic Therapeutics Treatment Trial viral infection with COVID-19 World Health Organization’ [DOI] 10.1038/s41598-020-76258-0 PMC 바로가기 [Article Type] Article
Impact of tocilizumab administration on mortality in severe COVID-19Article Published on 2020-11-052022-10-04 Journal: Scientific Reports [Category] 신약개발, 임상, 치료법, [키워드] 95% confidence interval age Analysis benefit biologics chronic pulmonary disease clinical trial cohort study Comorbidity contribute Control COVID-19 COVID-19 patients Cytokine storm dataset death Dementia Diabetes Mellitus died discharged disease Evidence exclusion criteria expired healthcare providers heart failure hospital immune response Impact in-hospital mortality Inclusion individuals with COVID-19 Inflammatory response male malignancy management Medical research Mortality Myocardial infarction novel coronavirus disease Odds ratio Patient patients with COVID-19 Primary outcome provide severe COVID-19 severity significantly more single-center stratified Support the patient therapeutic thought Tocilizumab tocilizumab administration was performed worldwide pandemic [DOI] 10.1038/s41598-020-76187-y PMC 바로가기 [Article Type] Article
Rapid Response Subunit Vaccine Design in the Absence of Structural Information구조적 정보가 없는 상황에서 신속한 반응 서브유닛 백신 설계Immunology Published on 2020-11-042022-09-11 Journal: Frontiers in Immunology [Category] 비임상, [키워드] Antigen Arenaviridae breath CEPI Clamp clinical trial Coalition Coalition for Epidemic Preparedness Innovations conducted coronavirus disease Coronavirus disease 2019 Course COVID-19 Disease X expected expressed expression level funding homogeneity Innovation lesson membrane fusion membrane fusion protein molecular clamp pandemic Paramyxoviridae Pathogens Phase I platform pre-fusion pre-fusion conformation Protein Rapid rapid response response screened subunit Subunit vaccine trimeric Vaccine development variant Viral viral pathogens virus [DOI] 10.3389/fimmu.2020.592370 PMC 바로가기 [Article Type] Immunology
Exploring the multifocal therapeutic approaches in COVID-19: A ray of hopeReview Published on 2020-11-032022-10-04 Journal: International immunopharmacology [Category] SARS, 진단, [키워드] acute respiratory syndrome Antithrombotic approved Care caused clinical investigation clinical trial confirmed case coronavirus Coronavirus-2 Corticosteroids COVID-19 current effective Effective therapies global pandemic Health Healthcare system highlight Human immunoglobulins immunotherapies Infectious disease intravenous knowledge Laboratory less life-threatening nocturnal Oxygen therapy pandemic plasma potential therapy Radiotherapy Research Safety SARS-CoV-2 therapeutic Therapeutic approach therapeutic option Therapies Treatment Treatment protocol Vaccine Vaccines virus [DOI] 10.1016/j.intimp.2020.107156 PMC 바로가기 [Article Type] Review
Salivary and Nasal Detection of the SARS-CoV-2 Virus After Antiviral Mouthrinses (BBCovid): A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-11-022022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] β-cyclodextrin 1:1 absence anticipated Antiviral antivirals Arm blinded Breastfeeding center change citrox® clinic clinical Clinical sign clinical trial Complete composed conducted Control control group COVID-19 criteria detection Diagnosis dissemination element eligibility Endocarditis Evolution France French hospital include Infection Infirmary Intervention investigator laboratory technician lack less Mouthwash mouthwashe nasal Nasal sample number Nurse objective outcome Parallel Arm participant Participants Patient PCR assay performed Placebo protocol question random randomisation randomised randomised controlled trial RCT Registered reported risk Roux salivary salivary and real-time PCR Sample size SARS-CoV 2 SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2 virus secondary Standard status study groups Study protocol supplementary material the SARS-CoV-2 Trial understanding Viral load website [DOI] 10.1186/s13063-020-04846-6 PMC 바로가기 [Article Type] Letter
Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019Review Article Published on 2020-11-022022-10-28 Journal: Annals of Medicine [Category] COVID-19, [키워드] acute respiratory syndrome adverse effect adverse effects analyzed anti-inflammatory agent Antigen presentation antigen processing antimalarial Antiviral Autoimmune Autoimmune diseases Cardiomyopathy Cardiotoxicity clinical trial conduction defect coronavirus coronavirus disease COVID-19 Efficacy Efficacy and safety Evidence functions HCQ Hydroxychloroquine immunomodulatory in-depth analysis inhibiting life-threatening lysosomal management manifestation mechanism mechanism of action mechanisms medical supervision MHC-II pandemic reported rheumatic disease systemic lupus erythematosus TLR use of hydroxychloroquine [DOI] 10.1080/07853890.2020.1839959 PMC 바로가기 [Article Type] Review Article
COVID-19 hits a trial: Arguments against hastily deviating from the planArticle Published on 2020-11-012023-07-02 Journal: Contemporary clinical trials [Category] SARS, [키워드] clinical trial Consistency COVID-19 Impact of the pandemic on trial conduct Trial adaptation. [DOI] 10.1016/j.cct.2020.106155 PMC 바로가기
Androgen sensitivity gateway to COVID-19 disease severityCOVID-19 질병 중증도에 대한 안드로겐 민감성 관문Article Published on 2020-11-012022-09-11 Journal: Drug development research [Category] SARS, 변종, 유전자 메커니즘, [키워드] activating addition alopecia androgen Androgen receptor androgens Anti-androgen benign prostatic hyperplasia Cell fusion children clinical trial COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 mortality determined by develop epidemiological Evidence explain Genetic variant genetic variants hospitalized COVID-19 patient hospitalized COVID-19 patients host susceptibility Infection male molecular mechanisms Neutralizing antibodies neutralizing antibody pandemic polycystic ovary Prostate cancer protease Protein receptor regulate required SARS-CoV-2 sensitivity Serine serine 2 severe symptom severe symptoms Spike protein syndrome the Spike TMPRSS2 Transcription transmembrane Trial variant Viral virus [DOI] 10.1002/ddr.21688 PMC 바로가기 [Article Type] Article