COVID-19: Consider IL-6 receptor antagonist for the therapy of cytokine storm syndrome in SARS-CoV-2 infected patientsCOVID-19: SARS-CoV-2 감염 환자의 사이토카인 폭풍 증후군 치료를 위해 IL-6 수용체 길항제 고려Article Published on 2020-11-012022-09-12 Journal: Journal of medical virology [Category] 진단, [키워드] acute respiratory syndrome antagonist clinical trial coronavirus COVID-19 COVID-19 patients Critical cytokine Cytokine storm Cytokine storm syndrome ENhance humanized monoclonal antibody IL-6 receptor IL-6R IL-6R antagonist Mortality Patient patients physician receptor reduce researcher sarilumab SARS-CoV-2 infected patient the cytokine storm therapeutic therapeutic option therapy Tocilizumab [DOI] 10.1002/jmv.26078 PMC 바로가기 [Article Type] Article
The significance of correct dosing of hydroxychloroquine in clinical trials of COVID-19Correspondence Published on 2020-11-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 임상, [키워드] clinical trial COVID-19 Hydroxychloroquine [DOI] 10.1016/j.ijid.2020.08.058 [Article Type] Correspondence
Waste in COVID-19 clinical trials conducted in western Europe서유럽에서 수행된 COVID-19 임상 시험의 폐기물Article Published on 2020-11-012022-09-11 Journal: European journal of internal medicine [Category] SARS, 임상, [키워드] Abstract clinical trial conducted coronavirus COVID-19 Europe Quality randomized clinical trials SARS-CoV-2 Single-arm trials waste [DOI] 10.1016/j.ejim.2020.07.002 PMC 바로가기 [Article Type] Article
Use of hydroxychloroquine and interferon alpha-2b for the prophylaxis of COVID-19COVID-19 예방을 위한 하이드록시클로로퀸 및 인터페론 알파-2b의 사용Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] 유전자 메커니즘, 임상, 치료제, [키워드] additive effects alpha-2b clinical trial COVID-19 COVID-19 infection Effect effective Efficacy Efficacy and safety effort Hydroxychloroquine IFN Infection Infectious disease interferon interferon alpha-2b intranasal knowledge low dose mechanisms pandemic of COVID-19 Prophylaxis randomized control study reduce solution Spread therapy Vaccine while [DOI] 10.1016/j.mehy.2020.109802 PMC 바로가기 [Article Type] Article
A proposed strategy for management of immunosuppression in heart transplant patients with COVID-19COVID-19 심장 이식 환자의 면역 억제 관리를 위한 제안된 전략Article Published on 2020-11-012022-09-11 Journal: Clinical transplantation [Category] SARS, 치료제, [키워드] Algorithm baseline Case fatality rate Clinical management clinical trial Cohort COVID-19 COVID-19 infection Data collection died disease Emergency Fatality rate had no Heart transplantation hospital Immunosuppression infection rate initial management Massachusetts median age men Mild Mild disease moderate disease one patient outcomes Patient patients patients with COVID-19 positive presenting reduced Remdesivir risk state of emergency tested therapy was performed [DOI] 10.1111/ctr.14032 PMC 바로가기 [Article Type] Article
Hydroxychloroquine in Hospitalized Patients with COVID-19: Real-World Experience Assessing MortalityCOVID-19로 입원한 환자의 하이드록시클로로퀸: 사망률을 평가하는 실제 경험Article Published on 2020-11-012022-08-31 Journal: Pharmacotherapy [Category] 신약개발, 임상, [키워드] 30-Day mortality 48 hour 48 hours 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age all-cause mortality Analysis antimalarial arrhythmia Assessing Azithromycin clinical trial Cohort conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 database diagnosis of COVID-19 experience Follow-up group groups HCQ Hospital admission hospitalized patients Hydroxychloroquine increase in investigated Macrolide male measure medications Mortality no difference Odds ratio off-label on admission outcome overall mortality Patient patients with COVID-19 Primary outcome real-world data receiving respiratory retrospective retrospective cohort study severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 statistically statistically significant the mean were recorded [DOI] 10.1002/phar.2467 PMC 바로가기 [Article Type] Article
Conduct of Clinical Trials in the Era of COVID-19: JACC Scientific Expert PanelReview article Published on 2020-11-012022-10-05 Journal: Journal of the American College of Cardiology [Category] 임상, [키워드] Analysis cardiovascular disease caused changed clinical clinical care clinical trial clinical trials composed Consensus coronavirus COVID-19 COVID-19 pandemic drug ecosystem endpoint ascertainment Europe expert failure food heart heart failure investigator pandemic Panel patients recommendation recommendations Research the United State [DOI] 10.1016/j.jacc.2020.09.544 [Article Type] Review article
Will patient-centric sampling become the norm for clinical trials after COVID-19? Correspondence Published on 2020-11-012022-10-05 Journal: Nature Medicine [Category] SARS, 진단, [키워드] clinical trial [DOI] 10.1038/s41591-020-01144-1 [Article Type] Correspondence
Repurposing current therapeutics for treating COVID-19: A vital role of prescription records data miningCOVID-19 치료를 위한 현재 치료제 용도 변경: 처방 기록 데이터 마이닝의 중요한 역할Article Published on 2020-11-012022-09-11 Journal: Drug development research [Category] Coronavirus, SARS, 신약개발, 임상, 치료제, [키워드] angiotensin Angiotensin receptor blockers approach approved assist Biomedical research claimed clinical trial clinical trials cohorts Community conditions controlled clinical trials COVID-19 COVID-19 patient COVID-19 patients criteria drug drug repositioning Drug repurposing EHR Electronic health record Electronic health records electronic health records (EHR). estradiol exclusion exclusion criteria faster Health Inclusion infected individual infected individuals morbidity open other conditions outbreak outcome over pandemic Patient PROTECT provide Receptor Blockers reducing repurposing retrospective SARS-CoV-2 pandemic severe COVID-19 symptoms Therapeutics TMPRSS2 treating COVID-19 patient Trial utility Vaccine with COVID-19 [DOI] 10.1002/ddr.21689 PMC 바로가기 [Article Type] Article
Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19Telmisartan, COVID-19에 대한 잠정적 지오텐신 수용체 차단제 치료제Article Published on 2020-11-012022-09-11 Journal: Drug development research [Category] SARS, 임상, [키워드] ACE2 airway alveolar cell alveolar cells Angiotensin 1-7 Angiotensin II angiotensin receptor blocker Apoptosis ARDS binds cascade China clinical trial complex Complication Concentration coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines decrease Degradation disease Election endocytosis Epidemic inflammatory process losartan lung membrane protein New coronavirus Open-label pharmacokinetic physiological pro-inflammatory produced proinflammatory cytokines promote Randomized reducing S protein SARS Coronavirus SARS-CoV-2 SARS-CoV-2 virus telmisartan telmisartan. the S protein therapeutic tissue treating COVID-19 patient turn type 2 alveolar cells virus Wuhan [DOI] 10.1002/ddr.21679 PMC 바로가기 [Article Type] Article