Evolutionary Relationships between Bat Coronaviruses and Their HostsResearch Published on 2007-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome analysis association bat bats biologic caused coronavirus Coronaviruses CoV CoVs Evolution evolutionary relationship examined Host host shifts Human implication occurred outbreak Phylogeny phylogeography recent related related viruses relationship Research Respiratory illness RNA-dependent RNA polymerase SARS SARS-CoV sequence shifting suggested trait traits virus virus [DOI] 10.3201/eid1310.070448 PMC 바로가기 [Article Type] Research
Pathogenetic mechanisms of severe acute respiratory syndromeArticle Published on 2007-09-072022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] acute respiratory disease acute respiratory syndrome affected angiotensin-converting enzyme 2 autopsy study Brain caused cell type cellular and molecular clinical manifestation contribute Diagnosis digestive tract Direct disease dysfunction enterocytes epithelial cell expressing hypoxia immune cells immune responses immune system implication include Infected Infection Injury kidneys liver lung mechanism morbidity and mortality neurons organ Other Pathogenesis pathological finding pathology pneumocyte primary target cell receptor renal SARS SARS-CoV severe target cell the disease therapy thyroid gland virus while [DOI] 10.1016/j.virusres.2007.01.022 PMC 바로가기 [Article Type] Article
Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus VaccinesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed antigen-presenting cell Author Cell culture Cell-mediated immunity cellular Cellular immune response coding sequence coronavirus Coronavirus infection coronavirus vaccine Coronavirus vaccines Coronaviruses Culture deleting dendritic cell disease elicited Factors Gene Expression genetics Heterologous homolog homologous IFN immune responses implication in vitro in vivo interfere long-lasting low dose macrophages Major MHV mice mouse hepatitis virus murine model mutant mutant virus non-structural protein pathogenicity plasmacytoid dendritic cells prevention Protective protective immune response Protein provide recombinant vaccine reduced replicate Replication replication-competent virus restored retained SARS-coronavirus sequence Spread T cell response tissue Type I IFN type I interferon vaccination Vaccine viral disease viral pathogenicity viral pathogens virus wild-type [DOI] 10.1371/journal.ppat.0030109 PMC 바로가기 [Article Type] Research Article
Long-Term Persistence of Robust Antibody and Cytotoxic T Cell Responses in Recovered Patients Infected with SARS CoronavirusResearch Article Published on 2006-12-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] against SARS-CoV Analysis antibody change changes in characterized clinical recovery CTL CTL epitope cytotoxic effective found humoral immune response immunological implication individual individuals Infected Infection Intervention moderate MOST N protein onset of symptoms outcome Patient peptides peripheral lymphocyte persistence recovered recovered patient response responses restored robust SARS Coronavirus SARS-CoV SARS-CoV-specific antibody study period subject Support T cell the disease therapeutic agent Vaccine [DOI] 10.1371/journal.pone.0000024 PMC 바로가기 [Article Type] Research Article
Factors associated with nosocomial SARS-CoV transmission among healthcare workers in Hanoi, Vietnam, 2003Research Article Published on 2006-08-142022-10-28 Journal: BMC Public Health [Category] Coronavirus, [키워드] 2003 95% confidence interval activity Analysis antibody assigned attack rate calculated Care Case-control category collected Community coronavirus cough detected disease Evidence Factor Fever group healthcare worker help highest highlight Hong Kong hospital implication increased risk individuals Infection Influenza lowest nosocomial Nurse occurred other respiratory infection outbreak Patient recommendation reported respiratory Result risk risk factor SARS-CoV SARS-CoV infection serologic serum severe specimen Spread subsequent Symptom the patient Transmission Univariate analysis was performed [DOI] 10.1186/1471-2458-6-207 PMC 바로가기 [Article Type] Research Article
Public health implications of using various case definitions in The Netherlands during the worldwide SARS outbreakOriginal Articles Published on 2006-08-072022-11-01 Journal: Clinical microbiology and infection : the official [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome analysed assessment Case definition caused Changing Confusion consequence criteria deviation different epidemiological FIVE Health implication Influenza management Measures Netherland outbreak pandemic Patient Perspective Public public health public health threats reported required resources risk Risk assessment SARS Sensitivity and specificity serological the patient the WHO Threats Virological were used [DOI] 10.1111/j.1469-0691.2006.01552.x PMC 바로가기 [Article Type] Original Articles
Neutralizing Antibody Response and SARS SeverityResearch Published on 2005-11-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome ADE age analyzed antibody Antibody decay clinical outcomes compared database death rate detectable Fisher exact test illness duration implication laboratory-confirmed linear mixed model Mortality neutralizing antibody Neutralizing antibody response Neutralizing antibody titer Pathogenesis Patient patients proportion Research Responder response SARS seroconverted Severity of infection shown survival Taiwan Vaccine [DOI] 10.3201/eid1111.040659 PMC 바로가기 [Article Type] Research