clinical trial – Page 198 – Communicable Diseases Research

Assessment of boron-containing compounds and oleoylethanolamide supplementation on the recovery trend in patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-10-272022-10-29
Journal: Trials [Category] Coronavirus, MERS, SARS,

Protection against SARS-CoV-2 by BCG vaccination is not supported by epidemiological analyses

Article

Published on 2020-10-272022-10-04
Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, 임상,

Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database

Genetics

Published on 2020-10-272022-10-31
Journal: Frontiers in Genetics [Category] COVID-19,

[키워드] ACE2 ACE2 expression acute respiratory syndrome Analysis analyzed angiotensin-converting enzyme 2 antiviral drug BALF BALF cell Bronchoalveolar lavage fluid candidate candidate drug Cell cells clinical trial co-expressed connectivity coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 database DEGs differentially expressed gene down-regulated gene drug effective expression functional enrichment functions gene cluster Genes healthy homologous identify immune defense immune dysfunction immune response indicated lung Map mechanism mRNA translation patients patients with COVID-19 performed positively correlated potential drugs public health crisis receptor reduce reflected regulatory agency Result RNA SARS-CoV SARS-CoV infection SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 synaptic transcriptome profile Transmission treat Treatment underlying mechanisms up-regulated Vaccine viral proliferation
[DOI] 10.3389/fgene.2020.558557 PMC 바로가기 [Article Type] Genetics

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

530

Published on 2020-10-272022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome animal model Antiviral antiviral activity antiviral drug Antiviral effect antiviral efficacy antiviral therapy Antiviral treatment baseline candidate Candidates clinical clinical trial Consensus Contact coronavirus COVID-19 COVID-19 patient COVID-19 patients dose drug effective Efficacy evaluate Evidence exhibit Favipiravir ferrets globe hamster hamsters High dose Human Hydroxychloroquine identify in vivo Infection infectious virus titer lack low dose lung Lung histopathology macaque Mild nontoxic preclinical model Prophylactic Prophylaxis protective effect reduced reduction in Repurposed drug required SARS-CoV-2 Significance significantly small molecule Spread suggested therapeutic toxic effects Transmission Treatment use of hydroxychloroquine viral disease virus virus levels virus transmission Wuhan
[DOI] 10.1073/pnas.2014441117 PMC 바로가기 [Article Type] 530

Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia

Neuroscience

Published on 2020-10-262022-10-31
Journal: Frontiers in Aging Neuroscience [Category] COVID-19,

[키워드] acute respiratory syndrome Affect Alzheimer Anxiety assessments Atypical bilateral pneumonia Brain Care caused change chronic clinical trial Cognition cognitive Cognitive impairment cognitive impairments Comorbidity consequence contributed coronavirus coronavirus disease COVID-19 Dementia described discharge disease drugs dysfunction Effect elderly evaluated exacerbate Factor form generate Healthcare systems high risk hospital Hospitalization hypoxia impacted implementation increasingly individual Insomnia intensive care loneliness manifestation measure mechanical ventilation medication Mental mental health Mild symptom Mortality multifactorial neurologic Neuropsychiatric neuropsychiatry organs Pandemics Patient Post-traumatic stress disorder potential mechanism Prevalence proportion provided Psychiatric rates of infection rehabilitation reported Research Respiratory system SARS-CoV-2 social distancing Spread survivor Symptom systemic inflammation these symptom treat triggering virus worsening
[DOI] 10.3389/fnagi.2020.588872 PMC 바로가기 [Article Type] Neuroscience

Tocilizumab: The Key to Stop Coronavirus Disease 2019 (COVID-19)-Induced Cytokine Release Syndrome (CRS)?

Medicine

Published on 2020-10-262022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial

COVID-19에 대한 타고난 면역 반응을 개선하기 위해 브라질에서 의료 종사자의 BCG 재접종: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2020-10-262022-08-13
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] accompany activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission Antibiotics antiviral immune response approved assigned Autoimmune Autoimmune diseases Bacillus BCG BCG revaccination BCG vaccination bcg vaccine blinded Blinding block blocks both groups Brazil Breastfeeding carried CFU Characteristics Chemotherapy childhood city clinical trial Committee Comorbidities Comorbidity confirmation Contact contact with control group Coronavirus-2 COVID-19 COVID-19 patient COVID-19 severity COVID-19 symptoms COVID-19 test cross-protection determined by diagnosed direct contact disease disease severity Diseases dissemination dose doses Effectiveness element elicited eligibility criteria Fever health worker health workers healthcare providers HIV hospital Hypothesis ICU identification number IgG and IgM IgM and IgG IgM test immunosuppressive IMPROVE in both group incidence incidence of COVID-19 Inclusion inclusion criteria India induce Infection infections information innate immune response investigator Laboratory lateral flow less macrophages medication meet memory monocyte Monocytes Mortality naso-oropharyngeal swab neutrophil Neutrophils NK NK cell number Nurses objective Open-label outcome outcomes pandemic parallel-group participant physiotherapists platform presenting Prevent Primary outcome Primary outcomes professional protocol randomisation randomised randomised controlled trial randomization Randomized receive recruit recruitment reduce Registered registration number researcher researchers respiratory revaccination right arm RT-PCR Sample size SARS-CoV-2 scar sealed Secondary objective Secondary objectives secondary outcome severe acute respiratory syndrome Coronavirus severity solid tumour specimen statistical analyses status steroid Study protocol Symptom symptomatic infection the disease the vaccine Trial Trial registration Tuberculosis two groups vaccination Vaccine virus virus infection virus infections was performed website WHO
[DOI] 10.1186/s13063-020-04822-0 PMC 바로가기 [Article Type] Letter

An investigation into the beneficial effects of high-dose interferon beta 1-a, compared to low-dose interferon beta 1-a (the base therapeutic regimen) in moderate to severe COVID-19: A structured summary of a study protocol for a randomized controlled l trial

Letter

Published on 2020-10-262022-10-29
Journal: Trials [Category] COVID-19, MERS, SARS,

[키워드] 1:1 accompany Admission age alcohol allocation concealment ALT/AST Arm assigned Beta block-randomization Blood body temperature Care clinical Clinical improvement clinical trial comparator Confirmed control group COVID COVID-19 COVID-2019 CT scan death discharge disease dissemination drug duration of hospitalization Effect Effectiveness element eligibility criteria exclusion criteria fatigue group headache Health High dose High-dose hospital hospital discharge Hospitalization improvement incidence include Infection information Interaction interferon beta Interferon beta-1a Interferon-β 1a intervention group Intubated Invasive mechanical ventilation investigator Kaletra Laboratory results lactating women Last less limit Loghman Hakim Hospital Lopinavir/ritonavir low dose low-dose masking mechanical ventilation Medical Sciences moderate Mortality nasal Non-invasive number objective open label Open-label outcome oxygen saturation oxygen support package parallel group participant Patient pregnant Primary outcome primary outcome measure professional protocol R software Radiation randomised randomization randomization sequence Randomized Randomized controlled trial Randomly receive Recigen recruitment refusal regimen Registered Research respiratory rate Ritonavir RT-PCR RT-PCR test Sample size SARS-CoV-2 sealed secondary secondary outcome seven-category ordinal scale severe disease Shortness of breath single center standard care status Study protocol Symptom the patient therapeutic time treated treatment groups Trial two groups university version 3.6.1 website World Health Organization
[DOI] 10.1186/s13063-020-04812-2 PMC 바로가기 [Article Type] Letter

The worldwide clinical trial research response to the COVID-19 pandemic – the first 100 days

Research Article

Published on 2020-10-262022-10-31
Journal: F1000Research [Category] COVID-19, MERS, SARS,

Stem cell therapy for COVID‐19, ARDS and pulmonary fibrosis

Review

Published on 2020-10-242022-10-31
Journal: Cell Proliferation [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory distress acute respiratory syndrome alveolar epithelial cell ARDS cause caused Cell clinical trial clinical trials coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 CRS Cytokine release syndrome Cytokines derivative Efficacy endothelial Exosomes Factor Factors FGF fibroblast function growth hearts HGF illnesses immune cells immune system KGF lung Mesenchymal stem cells MSC MSCs MSCs therapy Necrosis other organ paracrine Pathogenesis pathogenic Patient potential mechanism Potential treatment preclinical studies preclinical study progression promote PROTECT Protein pulmonary fibrosis quantified Registered regulate respiratory infectious disease SARS‐CoV‐2 secrete secreting secretion shown stem cell Stem cell therapy suggested supportive care syndrome the disease therapeutic therapeutic potential therapy tissue repair TNF‐α Treatment variety Vascular VEGF
[DOI] 10.1111/cpr.12939 PMC 바로가기 [Article Type] Review