SARS-CoV-2 vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals low levels of viral backbone gene transcription alongside very high levels of SARS-CoV-2 S glycoprotein gene transcriptionSARS-CoV-2 백신 ChAdOx1 nCoV-19 인간 세포주의 감염은 매우 높은 수준의 SARS-CoV-2 S 당단백질 유전자 전사와 함께 낮은 수준의 바이러스 백본 유전자 전사를 나타냅니다Research Published on 2021-03-152022-08-13 Journal: Genome Medicine [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] A549 A549 cell A549 cell line A549 cell lines A549 cells addition Adenovirus approach backbone Cell Cell culture cell line cell lines Cell Nucleus cells ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine clinical trial coding Direct RNA sequencing expected expression Gene Expression Genome globe HEK293 human cell line Infection nucleus phosphoproteome polyadenylation site Protein proteome proteomic proteomics Quantitative recombinant adenovirus Replication Result reveal S glycoprotein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S glycoprotein SARS-CoV-2 vaccine splice supplementary material the cell the SARS-CoV-2 transcript Transcription transcriptomic Vaccine Viral [DOI] 10.1186/s13073-021-00859-1 PMC 바로가기 [Article Type] Research
Renin-angiotensin system inhibitors and susceptibility to COVID-19 in patients with hypertension: a propensity score-matched cohort study in primary careResearch Article Published on 2021-03-152022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, [키워드] 1.26 95% CI ACE ACE inhibitor adjusted hazard ratio all-cause mortality Angiotensin-converting enzyme ARB ARBs association blocker CCB CCBs cohort study conducted COVID-19 COVID-19 in patient Cox proportional hazard database exposure group hypertension improvement incidence of COVID-19 incidence rate inhibitor investigated network Patient per 1000 person-year primary care RAS RAS inhibitor receptor respiratory Result risk of COVID-19 SARS-CoV-2 secondary outcome statistically supplementary material susceptibility treated [DOI] 10.1186/s12879-021-05951-w PMC 바로가기 [Article Type] Research Article
Multiple domains of functioning in older adults during the pandemic: design and basic characteristics of the Longitudinal Aging Study Amsterdam COVID-19 questionnaireArticle Published on 2021-03-152022-10-28 Journal: Aging Clinical and Experimental Research [Category] COVID-19, SARS, [키워드] Adults aging Characteristics cohort study coronavirus COVID-19 COVID-19 pandemic COVID-19 situation domain domains Epidemiology exceptional First wave longitudinal measure Mental Multiple Netherlands Older Older adults pandemic physical provided questionnaire respondent supplementary material [DOI] 10.1007/s40520-021-01829-8 PMC 바로가기 [Article Type] Article
Early public adherence with and support for stay-at-home COVID-19 mitigation strategies despite adverse life impact: a transnational cross-sectional survey study in the United States and AustraliaResearch Article Published on 2021-03-152022-10-28 Journal: BMC Public Health [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Administered age Anxiety caused contributed coronavirus coronavirus disease country COVID-19 COVID-19 mitigation Critical cross-sectional survey cumulative death rates deaths Depression elevated eligible female female gender Government implementation Infectious disease initial Insomnia Los Angele majority measure Measures mental health Mitigation strategies mounted Outbreaks outcomes pandemic positive Prevalence prevalent Public public health public health policy Qualtrics quarantine Region Regional reported Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections screened Stay-at-home orders subsequent supplementary material Support supported Surveillance Symptom the United State United State with COVID-19 [DOI] 10.1186/s12889-021-10410-x PMC 바로가기 [Article Type] Research Article
The impact of lockdown on pediatric ED visits and hospital admissions during the COVID19 pandemic: a multicenter analysis and review of the literatureOriginal Article Published on 2021-03-152022-10-31 Journal: European journal of pediatrics [Category] COVID-19, SARS, [키워드] Admission Admissions Analysis avoidance Care caused clinical care communicable condition Corona coronavirus disease COVID-19 COVID-19 pandemic COVID19 decrease diagnose Diagnosis Diseases ED visits Effect healthcare hospital Hospital admission Hospital admissions Hospitalization Infection infections linear literature review lockdown lockdowns multicenter Netherland Netherlands New pandemic pediatric pediatrics quantified reduction reduction in Registered reported SARS-CoV-2 significant decrease study period supplementary material transmission rates was performed [DOI] 10.1007/s00431-021-04015-0 PMC 바로가기 [Article Type] Original Article
Neurological symptoms in COVID-19: a cross-sectional monocentric study of hospitalized patientsResearch Article Published on 2021-03-122022-10-30 Journal: Neurological Research and Practice [Category] COVID-19, [키워드] Aachen abnormality affected Analysis ARDS assessment Brain caused cerebrospinal fluid Clinical characteristics cognitive deficit Cognitive impairment Complication complications of COVID-19 COVID-19 Critically ill cross-sectional CSF determine evaluated Evidence executive feasible feature functions Future Germany headache Hospitalized hospitalized COVID-19 patient hospitalized patient Hyposmia Invasion Laboratory Longitudinal assessment Major memory Montreal Neuro-invasive potential neurological Neurological deficit neurological manifestation neurological manifestations Neurological symptom Neurological symptoms nine non-critically ill patient olfactory Pain Patient patients patients with ARDS PCR polymerase chain positive positive SARS-CoV-2 PCR pro-inflammatory pulmonary symptoms radiological recall reported required respiratory Respiratory system responsible Result SARS-CoV-2 SARS-COV-2 infection stroke supplementary material Symptoms Test university virus weakness [DOI] 10.1186/s42466-021-00116-1 PMC 바로가기 [Article Type] Research Article
Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysisResearch Article Published on 2021-03-122022-10-27 Journal: BMC Biotechnology [Category] COVID-19, [키워드] Analysis applicability approach biological processe candidate drug candidate drugs Cluster collected complexes Coronavirus disease-19 costly COVID-19 COVID-19 pandemic database disease drug Drug discovery drug target drugs targeting effective drug experimental analysis experimental validation gene target Human identify Interaction investigated involved miRNA miRNAs network analysis PPI PPI network Protein protein-protein interaction Proteins provide reconstructed Regulation reported repurposing required researcher Result SARS-CoV-2 Seven Spread starting point supplementary material the SARS-CoV-2 virus therapeutic therapeutic purposes therapy therapy for COVID-19 time-consuming Toxicity treat Treatment urgency was obtained Wuhan, China [DOI] 10.1186/s12896-021-00680-z PMC 바로가기 [Article Type] Research Article
Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysisResearch Article Published on 2021-03-122022-10-27 Journal: BMC Biotechnology [Category] Coronavirus, COVID-19, SARS, [키워드] Analysis applicability approach biological processe candidate drug candidate drugs Cluster collected complexes Coronavirus disease-19 costly COVID-19 COVID-19 pandemic database disease drug Drug discovery drug target drugs targeting effective drug experimental analysis experimental validation gene target Human identify Interaction investigated involved miRNA miRNAs network analysis PPI PPI network Protein protein-protein interaction Proteins provide reconstructed Regulation reported repurposing required researcher Result SARS-CoV-2 Seven Spread starting point supplementary material the SARS-CoV-2 virus therapeutic therapeutic purposes therapy therapy for COVID-19 time-consuming Toxicity treat Treatment urgency was obtained Wuhan, China [DOI] 10.1186/s12896-021-00680-z PMC 바로가기 [Article Type] Research Article
Concerns, quality of life, access to care and productivity of the general population during the first 8 weeks of the coronavirus lockdown in Belgium and the NetherlandsResearch Article Published on 2021-03-122022-10-28 Journal: BMC health services research [Category] COVID-19, SARS, [키워드] age Belgium Burden of disease calculated Care children conducted coronavirus COVID-19 COVID-19 infection COVID-19 pandemic cross-sectional survey expected female General population Health healthcare lockdown majority Medical resource use medication MOST Netherland Netherlands pandemic population survey positive productivity proportion Quality of life questionnaire Questionnaires reported resource respondent Result Stress supplementary material tested [DOI] 10.1186/s12913-021-06240-7 PMC 바로가기 [Article Type] Research Article
COVID-19-related cancellation of elective orthopaedic surgery caused increased pain and psychosocial distress levelsSports Traumatology Published on 2021-03-122022-10-31 Journal: Knee Surgery, Sports Traumatology, Arthroscopy [Category] COVID-19, MERS, SARS, [키워드] age Arthroplasty Arthroscopy Care caused coronavirus coronavirus disease COVID COVID-19 COVID-19 pandemic Depression Depressive symptoms distress Elective surgery European country Evidence exhibited female female patient groups Health Health care system Health status information Level male moderate National not affected orthopedic surgery Pain pandemic Patient patients PHQ-9 predominant Psychosocial distress questionnaire Result SARS-CoV-2 significant difference significantly higher significantly increased sociodemographic data supplementary material surgeon Treatment women [DOI] 10.1007/s00167-021-06529-4 PMC 바로가기 [Article Type] Sports Traumatology