MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cellsmicroRNA는 표적 세포로 거의 전달되지 않는 세포 외 소포의 작은 성분입니다.Research Article Published on 2021-12-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Alter analyzed applied approach Biological functions Blood cells carried Cell cell line cell lines cell types cell-to-cell communication cellular cellular membrane cellular membranes contribute defined document effector effectors Evidence EVs Exosome Exosomes experiments extracellular vesicle Extracellular vesicles fraction functional FUSE had no majority mammalian cells messenger RNAs microRNA MicroRNAs Microvesicles miRNA miRNAs mRNA mRNAs packaged purified Quantitative recipient regulate RNAs Sensitivity and specificity stability target target cell target cells target mRNA Transcriptome Vesicle vesicles Viral viral miRNAs [DOI] 10.1371/journal.pgen.1009951 PMC 바로가기 [Article Type] Research Article
CYP2B6 Genotype and Weight Gain Differences Between Dolutegravir and EfavirenzCYP2B6 Dolutegravir와 Efavirenz의 유전자형 및 체중 증가 차이Online Only Articles Published on 2021-12-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] All participants Antiretroviral therapy ARMS ART baseline baseline CD4 baseline characteristics changes in Characteristics concentrations CYP2B6 difference dolutegravir dual-energy x-ray absorptiometry DXA efavirenz emtricitabine explain fat fumarate Gain Genotype genotyping greater HIV-1 Human immunodeficiency virus impair impaired weight men participant PLWH polymorphism Randomized Result RNA tenofovir tenofovir disoproxil fumarate variable weight weight gain women [DOI] 10.1093/cid/ciaa1073 PMC 바로가기 [Article Type] Online Only Articles
COVID-19 hospital admissions and deaths after BNT162b2 and ChAdOx1 nCoV-19 vaccinations in 2·57 million people in Scotland (EAVE II): a prospective cohort studyBNT162B2 및 Chadox1 NCOV-19 백신 접종 후 COVID-19 병원 입원 및 사망 (EAVE II) : 전향 적 코호트 연구Articles Published on 2021-12-012022-09-06 Journal: The Lancet. Respiratory Medicine [Category] Communicable Disease, COVID-19, Fulltext, SARS, [키워드] (Medical Research Council) 95% CI adjusted Admission Analysis BNT162b2 Care ChAdOx1 ChAdOx1 nCoV-19 challenge clinical factor clinical feature Comorbidities Comorbidity conducted COVID-19 COVID-19 hospitalisation COVID-19 illness COVID-19 mortality COVID-19 test COVID-19 vaccination programme COVID-19 vaccine death died enhanced estimate rate ratio finding first dose FIVE Frequency funding group Health Data Research UK help highest hospital Hospital admission hospitalisation hospitalised incidence individual individuals Industrial Innovation less male management Medical Research Council Mortality National Older age outcome pandemic Pfizer Pfizer–BioNTech platform Poisson regression model primary care prioritised vaccination prospective cohort study Protective rate ratios receiving risk risk of COVID-19 RRs RT-PCR testing SARS-COV-2 infection Scottish severe COVID-19 severe disease Social distancing measure social distancing measures Socioeconomic deprivation Strategy stratified study period Surveillance time-dependent Poisson regression model unvaccinated population unvaccinated populations vaccination Vaccine vaccine dose with COVID-19 [DOI] 10.1016/S2213-2600(21)00380-5 PMC 바로가기 [Article Type] Articles
Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans인간 곰팡이 병원체 암호화 코커스 데네 노모 인에서의 단성 재생산 동안의 동적 게놈 소성Research Article Published on 2021-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation addition Aneuploidy azole Cancer Cell cell cycle cell-cell fusion cells characterization characterized chromosome chromosomes concert conditions contributed copy number Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cyclin cyclins defect detect differentially expressed diploid duplication dynamic early phase eukaryotic events Evidence evidence of Evolution example form fungal fungi generate genes encoding Genetic Genome hallmark haploid Host host infection Implications in some increase independent instance intrinsic isolates kinase kinases lead maintain maintenance mechanism meiosis meiotic mitotic molecular mechanism molecular mechanisms nourseothricin nuclear nuclear fusion occur organism Organisms pathogen pathway plasticity ploidy polyploid public health Regulatory reporter serotype sexual development survival uracil VAR Variation [DOI] 10.1371/journal.pgen.1009935 PMC 바로가기 [Article Type] Research Article
Rates of viral suppression in a cohort of people with stable HIV from two community models of ART delivery versus facility-based HIV care in Lusaka, Zambia: a cluster-randomised, non-inferiority trial nested in the HPTN 071 (PopART) trial잠비아 Lusaka의 ART 전달과 시설 기반 HIV 치료의 두 가지 커뮤니티 모델에서 안정적인 HIV를 가진 사람들의 바이러스 억제 비율 : HPTN 071 (POPART) 시험에 중첩 된 클러스터 랜덤 화, 비 회개 시험.Articles Published on 2021-11-262022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI Abuse AIDS allergy Antiretroviral therapy ART assigned Care clinic clinician club Cohort Community Coverage death defined drug Drug Abuse effective Effectiveness eligible Emergency enrolled enrolment Evidence feasibility Final finding Follow-up for inclusion foundation funding group had no HBD health condition HIV Impact individual Infectious diseases initiative less Melinda Gate Melinda Gates mental health National non-inferiority margin non-inferiority trial participant Participants patients plan President Prevalence primary endpoint Primary outcome proportion provided Randomly Rate receiving relief risk risk difference RNA copy screened SOC Standard of care Support suppressed Treatment Trial Viral Viral load virological suppression with HIV written Informed Consent zone [DOI] 10.1016/S2352-3018(21)00242-3 PMC 바로가기 [Article Type] Articles
Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen돌연변이 속도 역학은 떠오르는 동물성 병원체의 생태 학적 변화를 반영합니다.Research Article Published on 2021-11-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, Fulltext, [키워드] accompanied adaptive antibiotic treatments Bacteria Bacterial bacterial pathogen Bacterial pathogens bacterial species bacterial specy carried change comparison conducted contribute disease driver Drivers ecological Ecology eight Evidence evidence of evolutionary dynamics experiment Factor faster Genetic variation Genome Host Host immune response host immune responses immune responses Impact independent of Infection influence invasive invasive disease involved isolate isolates less Mutation mutation rate Mutation rates natural no evidence of observé overcome pathogen pathogenic Pathogens populations predicted rapid increase respond species strain Strains Streptococcus understanding Variation while zoonotic [DOI] 10.1371/journal.pgen.1009864 PMC 바로가기 [Article Type] Research Article
Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR유연한 CFDR을 사용하여 GWAS 발견을 향상시키기 위해 임의의 분포에서 보조 데이터 활용Research Article Published on 2021-10-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach association associations Asthma auxiliary boost can be used category complex complex diseases Conditioning Control correlation covariate detect distribution distributions error rate Evidence evidence of experiments extension false discovery rate FDR functional Genetic genetic association genetic associations Genetic variant genetic variants Genome-wide association studies genomic genomic data genomic region GWAS Human genome identify implementation IMPROVE increase independent Interpretation iterations motivation not significant P -value Pleiotropy power provide Region required resource robust Sample size sensitivity SNP SNPs Statistical power Support Test statistics threshold traits UK Biobank data while [DOI] 10.1371/journal.pgen.1009853 PMC 바로가기 [Article Type] Research Article
Machine learning to predict the source of campylobacteriosis using whole genome data전체 게놈 데이터를 사용하여 Campylobacteriosis의 공급원을 예측하는 기계 학습Research Article Published on 2021-10-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy Algorithm allelic analysis approach Bacteria Bacterial Bacterial infections bacterium Bayesian inference Campylobacter jejuni Campylobacteriosis can be used cattle caused Classifier common disease complex core genome Disease surveillance DNA sequence DNA sequences drinking water effective interventions environmental reservoirs Epidemiology Evidence gastroenteritis Genes Genetic genetics Genome Human identify illnesses include infect infected individual infected individuals Infection infection source Intervention isolate isolates Lineage machine machine learning machine learning algorithm Machine learning algorithms occur Population genetics poultry predict provided Providing sequence sheep strain subset Transmission transmission potential Variation water WGS whole genome whole genome sequence [DOI] 10.1371/journal.pgen.1009436 PMC 바로가기 [Article Type] Research Article
Deciphering the genetic architecture and ethnographic distribution of IRD in three ethnic populations by whole genome sequence analysis전체 게놈 서열 분석에 의해 세 가지 민족 집단에서 IRD의 유전자 구조 및 민족 지학 분포를 해독합니다.Research Article Published on 2021-10-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition affected alteration American Analysis analyzed Atypical blood sample Blood samples causal variant Clinical diagnosis collected Combined complex consanguinity contributed contributing to disease pathology distribution dominant European examined Exome exome sequencing family member family members followed by GATK gene mutation gene mutations Genes genetic architecture genetic heterogeneity Genome genome analysis genome variant genome variants Genotype gnomAD hg19 identify Illumina individual initial linkage analysis mapped methodology minimum Mutation mutations ophthalmic pathology Patient pedigree phenotype PolyPhen2 Population populations proportion recruited reported responsible Retinal Degeneration sequence Sequencing Seven Spectrum Structural variant structural variants SVs The United States to define United States variant variants was performed WGS whole genome sequence whole-genome sequencing [DOI] 10.1371/journal.pgen.1009848 PMC 바로가기 [Article Type] Research Article
Radiological and functional evidence of the bronchial spread of tuberculosis: an observational analysis결핵의 기관지 스프레드의 방사선 및 기능적 증거 : 관찰 분석Articles Published on 2021-10-012022-09-06 Journal: The Lancet. Microbe [Category] Communicable Disease, [키워드] 2-Fluoro-2-deoxy-D-glucose Abstract active tuberculosis analysed Analysis animal model animal models baseline bronchial cavitary change China Chinese clinical clinical trial consolidations criteria CT scans cured described Developing diabetes Direct disease enrolled enrolment European Evidence examined explain extrapulmonary tuberculosis FDG finding foundation functional funding GeneXpert MTB/RIF granuloma HIV infection Inflammation Laboratory lesion lesions location Lungs material Melinda Gate Melinda Gates Mycobacterium tuberculosis natural participant partnership pathology Patient PET-CT positive pulmonary tuberculosis randomised rifampicin Science South Africa Spread sputum culture technology translation treated treated patient treated patients Treatment Treatment outcome Tuberculosis tuberculosis treatment viability were assessed were excluded [DOI] 10.1016/S2666-5247(21)00058-6 PMC 바로가기 [Article Type] Articles