[Troponin-T and n-terminal pro-brain type natriuretic peptide plasma levels and its relationship with mortality in COVID-19][트로포닌-T 및 n-말단 전뇌형 나트륨 이뇨 펩티드 혈장 농도 및 코로나19 사망률과의 관계]Article Published on 2022-07-012022-09-11 Journal: Hipertensión y riesgo vascular [Category] Coronavirus, 바이오마커, [키워드] 24 hour 24 hours 95%CI Admission age Altered analysed Analysis baseline Biomarcadores Biomarkers cardiovascular cardiovascular diseases classic coronavirus Coronavirus 2019 coronavirus disease Coronavirus disease 2019 COVID-19 cross-sectional cross-sectional study cytokine Cytokine storm described died eight subject elevated Endothelial dysfunction Enfermedad cardiovascular English Evidence fraction Hospital admission Hospitalization Hospitalized independent risk factor Inflammation involved material men moderate-severe Mortality Multivariate analysis myocarditis Natriuretic Natriuretic Peptide, B-Type NT-proBNP Patient patients peptide Péptido natriurético tipo-B plasma prothrombotic state remained retrospective cohort SARS-CoV-2 Spanish subject Symptom the cytokine storm troponin Troponin-T Troponina T unit with COVID-19 [DOI] 10.1016/j.hipert.2022.03.002 PMC 바로가기 [Article Type] Article
A pilot phase Ib/II study of whole-lung low dose radiation therapy (LDRT) for the treatment of severe COVID-19 pneumonia: First experience from AfricaClinical Trial Published on 2022-07-012022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] 24 hour absence benefit cellular proliferation clinical benefit clinical trial Complete condition conducted COVID-19 CRP Cytokine storm D-dimer Day death defined demonstrated died discharge discharged dose Efficacy elevated enrolled feasibility feasible fraction High-resolution HRCT identify Inflammatory marker inhibit investigator-initiated Kenya low dose lung management mechanical ventilation median time on mechanical ventilation oxygen Oxygen requirement Oxygenation Patient patients PCR Pneumonia polymerase chain primary endpoint progressed radiation therapy remained resources SAE Safe secondary endpoint Sepsis severe COVID-19 Severe COVID-19 pneumonia the patient therapy Toxicity treat treated Treatment Trial university Vaccine were excluded [DOI] 10.1371/journal.pone.0270594 PMC 바로가기 [Article Type] Clinical Trial
Early dexamethasone use as a protective measure in non-mechanically ventilated critically ill patients with COVID-19: a multicenter, cohort study Research Published on 2022-06-132022-10-05 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] 1:1 24 hour benefit cohort study consequence COVID-19 COVID19 Critically ill patient debatable Dexamethasone higher odd hospital ICU admission ICUs in-hospital mortality initiated intensive care unit LOS mechanical ventilation Mortality multicenter multicenter cohort study outcome Patient patients with COVID-19 Prevent primary endpoint Propensity score Protective required Respiratory failure SOFA score statistically significant the timing Tocilizumab two group Ventilated ventilated patients was used with COVID-19 [DOI] 10.1038/s41598-022-13239-5 [Article Type] Research
Point-of-Care Ultrasound Predicts Clinical Outcomes in Patients With COVID-19현장 진료 초음파로 COVID-19 환자의 임상 결과 예측Article Published on 2022-06-012022-09-11 Journal: Journal of Ultrasound in Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] 24 hour 24 hours Admission Adult patients appear blinded clinical clinical implications Clinical outcome clinical outcomes collected conducted confidence interval consolidation consolidations COVID-19 criteria Critically ill critically ill patients detect discharge evaluate hospital ICU ICU admission inclusion criteria intensive care intensive care unit intubation less lung manifestation Mortality Odds ratio outcome outcomes oxygen Patient patients patients hospitalized POCUS predict Predictive Primary outcome prospective cohort study Protective protocol risk stratification secondary Secondary outcomes supplemental oxygen symptom onset Ultrasound [DOI] 10.1002/jum.15818 PMC 바로가기 [Article Type] Article
Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19SARS-CoV-2에 감염된 Caco-2 장 세포에서 CDH1/E-Cadherin 유전자 발현 및 가용성 형태의 E-Cadherin 방출 제어: COVID-19의 장 형태에 대한 생리병리학적 결과Article Published on 2022-05-042022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] 24 hour 24 hours 48 hour 48 hours ACE2 ACE2 mRNA Affect AT1 Caco-2 Caco-2 cell Caco-2 cells cadherin CDH1 Cell cell line cells Co-receptor connexin consequence contributing to Control COVID-19 Culture culture supernatant diarrhoea diarrhoea) digestive tract Disruption dissemination down-regulated dysregulation E-cadherin ENCODE epithelial exposure to expresse expression form Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract HCoV HCoV-OC43 HLA class I human ACE2 illnesses in viral induce infected with SARS-CoV-2 Infection intestinal Intestinal barrier intestinal cells intestinal tissue intranasal involved JAMA junctions leads membrane mRNA mRNA expression OC43 occludin pandemic Patient Physiopathological Post-infection Protein receptor receptor ACE2 Release remained reported respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection significant increase significantly lower Symptom the disease these symptoms TMPRSS2 Transcription transgenic mice Trigger Viral viral entry virus [DOI] 10.3389/fcimb.2022.798767 PMC 바로가기 [Article Type] Article
Analysis of clinical characteristics of 66 pediatric patients with B.1.617.2 (Delta) variant of COVID-19COVID-19의 B.1.617.2(델타) 변이형 소아 환자 66명의 임상적 특성 분석Article Published on 2022-05-012022-09-11 Journal: World Journal of Pediatrics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] 24 hour 24 hours accumulate acute respiratory syndrome acute respiratory syndrome coronavirus Admission age All the patient all the patients Analysis analyzed antibody B.1.617.2 B.1.617.2 (Delta) cardiac troponin Cardiac troponin I Characteristics children children with COVID-19 clinical Clinical characteristics clinical experience Clinical features clinical symptom Clinical symptoms Cluster coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Cycle threshold value Cycle threshold values D-dimer Delta description disease onset erythrocyte sedimentation erythrocyte sedimentation rate evaluate Frame Gender Genome gradually increased group help hospital IgG IgM IgM antibodies IgM antibody Immunoglobulin Incubation period laboratory data medical staff Mild moderate nucleocapsid protein Open reading frame open reading frame 1 Pediatric patient positive respiratory sedimentation rate severe acute respiratory syndrome Coronavirus statistically significant difference Symptom tested titers troponin I variant [DOI] 10.1007/s12519-022-00529-1 PMC 바로가기 [Article Type] Article
Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemicResearch article Published on 2022-05-012022-10-05 Journal: Heart Rhythm [Category] 신약개발, [키워드] 24 hour African African American APD arrhythmia baseline cells condition conditions coronavirus disease COVID-19 COVID-19 pandemic death Drug-induced long QT syndrome early stage Effect had no HCQ Hydroxychloroquine increase in individual Induced pluripotent stem cell–derived cardiomyocyte Long QT syndrome male no difference objective p.Ser1103Tyr-SCN5A pandemic physiological polymorphism Result risk SCD SCN5A significant increase significantly significantly higher Stress Treatment variant was used [DOI] 10.1016/j.hrthm.2021.12.029 [Article Type] Research article
Offering mailed nicotine replacement therapy and Quitline support before elective surgery: a randomised controlled trialRandomized Controlled Trial Published on 2022-04-182022-10-05 Journal: The Medical journal of Australia [Category] 임상, [키워드] 24 hour 95% CI added addition adverse event adverse events Care clinical control group Controlled trial delivery Delivery of healthcare education Education, public health Elective surgery eligible participant Frequency Health Health promotion Health services research hospital medicine increase Intervention intervention group Melbourne New Odds ratio offer Offering outcome participant Perioperative Perioperative care prehospital Prehospital care preventive health services proportion randomised controlled trial registry reported risk secondary Seven smoker smoking Support tertiary referral hospital therapy Treatment outcome Trial uptake [DOI] 10.5694/mja2.51453 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effect of Sotrovimab on Hospitalization or Death Among High-risk Patients With Mild to Moderate COVID-19: A Randomized Clinical TrialRandomized Controlled Trial Published on 2022-04-052022-10-05 Journal: JAMA [Category] COVID19(2023년), SARS, 변종, 임상, 진단, 치료제, [키워드] 1:1 24 hour absolute difference acute illness adjusted adjusted relative risk Adverse adverse event age all-cause hospitalization Brazil Canada clinical clinical trial collected conducted COVID-19 COVID-19 progression Critical death diarrhea Disease progression duration of follow-up Effect Efficacy end point evaluate event favor Follow-up high-risk patient Hospitalization increased risk infected with SARS-CoV-2 interim analysis intravenous intravenous dose Latinx management mechanical ventilation median age Mild Moderate COVID-19 neutralizing antibody outcome Patient patients randomized patients with COVID-19 Placebo Pneumonia Prevent Primary outcome progression proportion Randomized reduced requiring supplemental oxygen risk risk factor SARS-CoV-2 variant secondary outcome severe disease significantly Sotrovimab Spain statistically significant Support symptomatic tested the median those with comorbidity Treatment treatment group [DOI] 10.1001/jama.2022.2832 PMC 바로가기 [Article Type] Randomized Controlled Trial
Prone Position in COVID-19 and -COVID-19 Acute Respiratory Distress Syndrome: An International Multicenter Observational Comparative StudyObservational Study Published on 2022-04-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] 24 hour acute respiratory distress age cohort study Comparative Compliance coronavirus disease COVID-19 defined France greater Hospital admission ICU IMPROVE increase in International intubation Italy kPa less measurement median time Mortality multicenter no significant difference Odds ratio outcome overall mortality Oxygenation oxygenation response Patient position prone Prone position proning proportion respiratory Responder responders severe disease survival syndrome United Kingdom variable [DOI] 10.1097/CCM.0000000000005354 PMC 바로가기 [Article Type] Observational Study