Effects of non-invasive respiratory supports on inspiratory effort in moderate-severe COVID-19 patients. A randomized physiological studyRandomized Controlled Trial Published on 2022-06-012022-10-05 Journal: European journal of internal medicine [Category] 임상, [키워드] applied arterial blood collected COVID COVID 19 COVID-19 COVID-19 patients CPAP dependent on driving early phase Effect elevated failure form HFNC Hypoxemic acute respiratory failure induced Inspiratory effort Intubated invasive Lung injury minute moderate-severe MONITOR nasal NIV Non invasive respiratory supports. Non-invasive respiratory support non-invasive ventilation Occurrence Oxygenation P-SILI PaO Patient patients physiological positive airway pressure potential risk pressure random Randomized rationale reduce reducing reduction in respiratory Respiratory failure Respiratory Support self significantly standard oxygen therapy statistically significant difference suggested the patient treat Trial Ventilation ventilator were recorded [DOI] 10.1016/j.ejim.2022.04.012 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effects of different doses of methylprednisolone on clinical outcomes in patients with severe community-acquired pneumonia: a study protocol for a randomized controlled trial중증 지역사회획득 폐렴 환자의 임상 결과에 대한 다양한 용량의 메틸프레드니솔론 효과: 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-05-212022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 28-day mortality Chinese clinical Clinical efficacy Clinical outcome clinician community-acquired pneumonia complications Consensus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment determine diagnosed different dose different doses dose dose-dependent double-blind Effect Efficacy Efficacy and safety Endotracheal intubation evaluate Final four group Frequency gastrointestinal hemorrhage glucocorticoid help Hospital stay hyperglycemia ICU interleukin interleukin-6 mechanical ventilation duration Methylprednisolone normal saline Nosocomial infections optimal dose PaO parallel group Patient Placebo placebo-controlled trial Primary outcome protocol randomization Randomized Randomized controlled trial registry SCAP secondary outcome Secondary outcomes serum CRP Severe community-acquired pneumonia. Study protocol temperature treat Treatment Vasopressor vasopressors ventilator-free day Volume [DOI] 10.1186/s13063-022-06404-8 PMC 바로가기 [Article Type] Article
Study protocol for a single-centre randomised controlled trial to investigate the effect of lung recruitment in paediatric patients after cardiac surgery심장 수술 후 소아 환자에서 폐 모집의 효과를 조사하기 위한 단일 센터 무작위 대조 시험에 대한 연구 프로토콜Article Published on 2022-05-172022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome after cardiac surgery approval arrhythmia arterial oxygen tension article barotrauma cardiac Cardiac surgery China clinical trial Compliance conferences Critical Critical care decrease determine Ethics ethics committee fraction guidelines Hospital stay Hypotension hypoxaemic respiratory failure IMPROVE Intensive intensive care intensive care unit lung recruitment mechanical ventilation Mortality non-invasive ventilation Occurrence oxygen Oxygenation Paediatric cardiac surgery Paediatric intensive & paediatric patient paediatric patients PaO Patient peer-reviewed postoperative primary endpoint protocol protocols protocols & pulmonary complications randomised controlled trial Randomly reduce registration number respiratory distress Respiratory failure Respiratory system secondary endpoint Secondary endpoints Serious Adverse Event Serious Adverse Events syndrome Trial university Ventilator-free days West [DOI] 10.1136/bmjopen-2022-063278 PMC 바로가기 [Article Type] Article
Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness studyObservational Study Published on 2022-05-042022-10-05 Journal: The BMJ [Category] COVID19(2023년), SARS, 임상, [키워드] 95% confidence interval adherence adjusted Admission baseline calculated clinically suspected competing country driving ECMO effective Effectiveness eligible patient estimate event extracorporeal membrane oxygenation FIVE Follow-up fraction hospital hypoxaemia intensity intensive care Laboratory mechanical ventilation Mortality observational study outcome oxygen PaO Patient Primary outcome Probability reduction in mortality Respiratory failure risk SARS-COV-2 infection Secondary analyses selected severity Treatment Treatment effectiveness Weighting [DOI] 10.1136/bmj-2021-068723 PMC 바로가기 [Article Type] Observational Study
Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill COVID-19 patients at high altitudesObservational Study Published on 2022-05-012022-10-04 Journal: Respiratory physiology & neurobiology [Category] 임상, [키워드] Alto association automatically Blood central respiration connection COVID-19 COVID-19 patient Critically ill Critically ill patient cross-sectional death evaluated event expected fraction Frequency help high-altitude hyperoxemia Hypoxemia hypoxemic ICU IMPROVE intensive care intensive care unit intubated patient intubated patients intubation Invasive mechanical ventilation liberal liberal oxygen therapy life-threatening limit maintain Mortality multicenter normoxemia. normoxia overcome oxygen Oxygen therapy Oxygenation PaO Patient peripheral oxygen saturation Prognosis receive required Respiratory failure rises SOFA score suggested Support survival therapy undergo was performed [DOI] 10.1016/j.resp.2022.103868 PMC 바로가기 [Article Type] Observational Study
Clinical and laboratory predictors at ICU admission affecting course of illness and mortality rates in a tertiary COVID-19 center3차 COVID-19 센터의 질병 경과 및 사망률에 영향을 미치는 ICU 입원 시 임상 및 실험실 예측 변수Observational Study Published on 2022-05-012022-09-11 Journal: Heart & lung : the journal of critical care [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료기술, [키워드] Admission affected affecting age Analysis analyzed applied Arterial hypertension bacterial superinfections baseline clinical clinical feature Clinical features Cohort Comorbidities congestive heart failure Course COVID-19 COVID-19 patient COVID-19 patients Critical care Critically ill critically ill COVID-19 patients Croatia CRP determine Factor Features hospital hypertension ICU ICU admission IL-6 increase Inflammatory biomarker Invasive mechanical ventilation Laboratory laboratory parameter Laboratory parameters Length Mortality mortality rate mortality rates mortality risk multivariate adjustment outcome PaO predict predictor primary endpoint primary endpoints Regression model retrospective risk factor Risk factors Serum ferritin SOFA SOFA score survival survival analysis survival rates Survivors therapeutic intervention therapeutic interventions treated Trial utility [DOI] 10.1016/j.hrtlng.2022.01.013 PMC 바로가기 [Article Type] Observational Study
The early use of sepsis scores to predict respiratory failure and mortality in non-ICU patients with COVID-19Case Reports Published on 2022-05-012022-10-05 Journal: Revista clínica española [Category] 임상, [키워드] adults hospitalized assessment coronavirus COVID-19 COVID-19 patients cutoff point death defined died discrimination Early warning scores English failure Fallo respiratorio Hospitalized ICU intensive care unit mechanical ventilation Mortality non-ICU patient occurred PaO Patient patients with COVID-19 predict qSOFA respiratory Respiratory failure Retrospective study SARS-CoV-2 score Sepsis Sepsis-Related Organ Failure Assessment. SOFA Spanish with COVID-19 [DOI] 10.1016/j.rceng.2020.10.004 PMC 바로가기 [Article Type] Case Reports
Predictors of intubation in COVID-19 patients treated with out-of-ICU continuous positive airway pressureObservational Study Published on 2022-05-012022-10-04 Journal: Pulmonology [Category] 임상, [키워드] age Analysis baseline C-reactive protein candidate change Clinical data collected Comorbidity Continuous Continuous positive pressure ventilation coronavirus disease COVID-19 COVID-19 patient CPAP determine fraction Gender increase in intubation Lactate lactate dehydrogenase LDH male multicentre outcome oxygen PaO Patient patients patients treated positive positive airway pressure predictor Predictors of intubation Respiratory failure respiratory rate retrospective ROX index SARS-CoV-2 significantly significantly lower subsequent therapeutic treated Treatment White blood cell white cell [DOI] 10.1016/j.pulmoe.2020.12.010 PMC 바로가기 [Article Type] Observational Study
Rapidly improving acute respiratory distress syndrome in COVID-19: a multi-centre observational studyObservational Study Published on 2022-04-142022-10-04 Journal: Respiratory Research [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome Acute respiratory failure ARDS association consecutive patient contribute coronavirus coronavirus disease COVID-19 criteria defined determine distress fraction greater Greece high mortality rate ICU increasingly intensive care unit interquartile range intubated patient intubation Invasive mechanical ventilation less median Mortality occurred oxygen pandemic PaO Patient patients with ARDS patients with COVID-19 Pneumonia Prevalence prevalent Prognosis receiving reported severe ARDS syndrome trajectory trials with COVID-19 [DOI] 10.1186/s12931-022-02015-8 PMC 바로가기 [Article Type] Observational Study
Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trialClinical Trial Published on 2022-04-082022-10-05 Journal: Critical Care [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress addition adverse event all-cause mortality all-cause mortality rate Auxora baseline calcium channel inhibitor chest imaging clinical trial Corticosteroid COVID-19 hospitalization CRAC CRAC channel inhibitor Day declining determine diagnosis of COVID-19 double-blind Efficacy endothelial integrity Enrollment enrolment groups Guidance Infection Invasive mechanical ventilation Laboratory testing less medication nasal Non-invasive occurred Oxygen therapy PaO Patient patients treated Placebo placebo-controlled trial Pneumonia polymerase chain primary endpoint Proinflammatory cytokine pulse oximetry Randomized randomized patients randomized-controlled receiving Regulatory required Respiratory failure SAE SAEs Safe secondary endpoint severe COVID-19 Severe COVID-19 pneumonia Standard of care Symptom syndrome time Time to recovery treat Treatment Trial with COVID-19 [DOI] 10.1186/s13054-022-03964-8 PMC 바로가기 [Article Type] Clinical Trial