Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody
내피 eNAMPT는 전임상 급성 폐 손상을 증폭합니다: eNAMPT 중화 단일클론 항체의 효능
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[키워드] abrogate
Activation
acute respiratory distress
acute respiratory distress syndrome
acute respiratory syndrome
amplify
antibody
ARDS
assays
BAL
biochemical
biologic
Biomarker
Bronchoalveolar lavage
cells
Combination
coronavirus
coronavirus disease
demonstrated
detect
disease
effective therapy
Efficacy
Endothelial cell
eosin
expression
Extracellular
genotyping
Haematoxylin
highlight
human lung
identify
in vitro
in vivo
increases in
Inflammation
Inflammatory
inflammatory lung injury
Innate immunity
interleukin-6
knockout mice
Ligand
lipopolysaccharide
lung
Lung injury
lung tissue
lung tissues
mAb
master regulator
mice
monoclonal antibody
Mortality
NAMPT
Neutralising Antibodies
nicotinamide
offer
pandemic
pathway
personalised
plasma
polyclonal
polyclonal antibody
polymorphonuclear
Predictive
probe
Protein
receptor
reduce
respiratory
respiratory distress
severe acute respiratory syndrome Coronavirus
severity
significantly
staining
subject
syndrome
therapeutic target
TLR4
Toll-like receptor
unmet need
was used
were used
wild-type
[DOI] 10.1183/13993003.02536-2020 PMC 바로가기 [Article Type] Article
[DOI] 10.1183/13993003.02536-2020 PMC 바로가기 [Article Type] Article