Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion
말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다
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Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,
[키워드] Accessibility
anti-spike protein IgG
Antiviral
ATAC-seq
CD14
CD14+ monocytes
Cell
cell differentiation
cell type
cell types
changes in
chromatin
classical
Course
COVID-19
COVID-19 disease severity
defined
diagnostic
disease
disease course
dysregulated
early disease
effective
epigenome
Evolution
hosts
IgG
immune response
immune responses
individual
Infection
interleukin
interleukin signaling
IRF1
IRF7
less
Mild
mild SARS-CoV-2 infection
Mild symptom
moderate
moderate disease
moderate symptom
Modification
modifications
Monocytes
mononuclear cell
mononuclear cells
morphology
motif
observation
occurred
offer
Outpatient
outpatients
Pathways
PBMC
PBMCs
performed
Peripheral blood
Peripheral blood mononuclear cells
profile
promise
Regulation
remodeling
responses
RNA-Seq
robust
SARS-CoV-2
SARS-COV-2 infection
Sequencing
Seroconversion
severity
Signaling
single-cell analyses
single-cell analysis
Stage
Symptom
symptom severity
the disease
transcription factor
transposase
Trigger
triggers
upregulation
with COVID-19
[DOI] 10.1038/s41598-022-15668-8 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41598-022-15668-8 PMC 바로가기 [Article Type] Article