Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Outcomes in Patients Hospitalized for COVID-19Observational Study Published on 2021-12-212022-10-05 Journal: Journal of the American Heart Association [Category] 임상, [키워드] 95% CI ACE ACE inhibitors ACEi/ARB adjusted hazard ratio Affect Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors association biomarkers of inflammation blood pressure C-reactive protein cell entry receptor clinical COVID-19 COVID‐19 death deaths dialysis dose examined Hospitalization In-hospital In-hospital death inclusion criteria Inflammation lower risk Measures mechanical ventilation modulating Mortality multivariable analysis need for dialysis outcome outcomes Patient patients hospitalized receptor Registration required Result SARS-CoV2 serum creatinine symptomatic thought Treatment Trial Ventilation [DOI] 10.1161/JAHA.121.023535 PMC 바로가기 [Article Type] Observational Study
Three-Year Clinical Outcomes of the First South Asian Prospective Longitudinal Observational IgA Nephropathy CohortRegional Report Published on 2021-11-242024-09-04 Journal: Kidney International Reports [Category] 대상포진, [키워드] ACE inhibitors Glomerulonephritis IgA nephropathy nephrotic syndrome Proteinuria Renal pathology [DOI] 10.1016/j.ekir.2021.11.012 PMC 바로가기 [Article Type] Regional Report
Whey-Derived Peptides at the Heart of the COVID-19 PandemicCOVID-19 팬데믹의 중심에 있는 유청 유래 펩타이드Article Published on 2021-10-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] ACE ACE inhibitor ACE inhibitors ACE inhibitory activity ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach association blood pressure blood pressure homeostasis Captopril cells component coronavirus COVID-19 COVID-19 pandemic drugs dual enzyme exhibiting heart human ACE2 hypertension inhibit inhibitory inhibitory action inhibitory activity IPP Lisinopril molecular docking molecular interaction peptide peptide sequences peptides Previous studies produced RAS RAS inhibitor RAS inhibitors receptor reduced risk renin–angiotensin system renin–angiotensin system reported respiratory SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus shown synthetic drugs therapeutic Treatment treatment of COVID-19 were assessed whey peptides [DOI] 10.3390/ijms222111662 PMC 바로가기 [Article Type] Article
In-hospital use of ACE inhibitors/angiotensin receptor blockers associates with COVID-19 outcomes in African American patients아프리카계 미국인 환자의 COVID-19 결과와 관련된 ACE 억제제/안지오텐신 수용체 차단제의 병원 내 사용Clinical Trial Published on 2021-10-012022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 유전자 메커니즘, 임상, [키워드] 95% CI ACE ACE inhibitors ACE1 African American African Americans allele angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme ARB association blocker cardiovascular cardiovascular disease coronavirus disease Coronavirus disease 2019 COVID-19 drug drug therapy Epidemiology evaluated hospital improved mortality In-hospital in-hospital mortality mechanism medication Mortality Mount Sinai multivariate logistic regression multivariate logistic regression model New York City outcome Pathogenesis Patient patients with COVID-19 prevalent receptor reduced reduced risk reduction in severe coronavirus disease significantly tested with COVID-19 [DOI] 10.1172/JCI151418 PMC 바로가기 [Article Type] Clinical Trial
Hospital mortality in COVID-19 patients in Belgium treated with statins, ACE inhibitors and/or ARBsObservational Study Published on 2021-09-022022-10-05 Journal: Human vaccines & immunotherapeutics [Category] SARS, 임상, [키워드] 28-day mortality 95% CI ACE ACE inhibitor ACE inhibitors ACEIs activity angiotensin receptor blocker Angiotensin receptor blockers ARB ARBs Belgium Case-control characterized clinical trial Combination combination treatment COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients determine drug Endothelial cell Endothelial dysfunction help hospital Hospital mortality hospitalized COVID-19 patients immunometabolism IMPROVE In-hospital maintain Mortality observational study pathogenesis of COVID-19 Propensity score receptor reduced reduction in statins survival treated Treatment unlikely Vaccine [DOI] 10.1080/21645515.2021.1920271 PMC 바로가기 [Article Type] Observational Study
Comparison of Medication Prescribing Before and After the COVID-19 Pandemic Among Nursing Home Residents in Ontario, CanadaObservational Study Published on 2021-08-022022-10-04 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] absolute difference accelerate ACE ACE inhibitors adverse effect Affect Analysis angiotensin receptor blocker Angiotensin-converting enzyme Antibiotics ARBs association average base Canada Care change changes in Cohort cohorts consequence Course COVID-19 COVID-19 pandemic Effect exposure finding function Health home Importance increases in inhibitors initial Intervention measure medication medications MONITOR Nursing objective observation observation period Older Onset outcomes pandemic parameter participant Point population-based cohort prescribing prescription medication professional proportion ranged Relevance resident Result selected setting significant increases in significant level standard error statistically significant tested Uncertainty use of antibiotics Weekly [DOI] 10.1001/jamanetworkopen.2021.18441 PMC 바로가기 [Article Type] Observational Study
Covid-19 pandemic: Perspectives on management코로나19 팬데믹: 경영에 대한 관점Review Published on 2021-08-012022-09-11 Journal: Journal of reproductive immunology [Category] SARS, 임상, 치료제, [키워드] ACE ACE inhibitors angiotensin Angiotensin receptor blockers assisted ventilation benefit Care clinical trials country COVAX COVID-19 COVID-19 vaccines decrease develop Dexamethasone dissemination distribution drug effective effective drug effective drugs effective therapy Efficacy Evidence evidence of form hypoxia ICU care identify in vitro activity Infection low dose dexamethasone management medical treatment Mild mRNA-based vaccine pandemic Patient Pneumonia preliminary evidence preventing infection progression provided randomized trial randomized trials receptor refrigeration Regulatory Remdesivir required retroviral SARS-CoV-2 severe disease shown supportive care the WHO Treatment vaccination Vaccine Vaccines virus [DOI] 10.1016/j.jri.2021.103344 PMC 바로가기 [Article Type] Review
Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019자물쇠, 재고 및 배럴: 코로나바이러스 질병 2019에서 레닌-안지오텐신-알도스테론 시스템의 역할Review Published on 2021-07-112022-09-12 Journal: Cells [Category] SARS, 진단, [키워드] ACE inhibitors ACE2 caused Cell cell receptor characteristic Community contribute COVID-19 drug dysfunction early stage form host cell increase in infect Infection involved lock molecular target organotropism pandemic Pathogenesis pathogenesis of COVID-19 plasma RAAS receptor renin-angiotensin-aldosterone system role SARS-CoV2 sartans stock subject System the disease therapeutic option virus zinc-chelating agents [DOI] 10.3390/cells10071752 PMC 바로가기 [Article Type] Review
Shining More Light on RAS Inhibition during the COVID-19 PandemicCOVID-19 전염병 동안 RAS 억제에 대해 더 많은 빛을 비추다Editorial Published on 2021-07-012022-09-11 Journal: Clinical journal of the American Society of Nephro [Category] SARS, 임상, [키워드] Abstract ACE ACE inhibitors angiotensin COVID-19 dialysis inhibition kidney Kidney transplantation LIGHT Mortality RAS Virology [DOI] 10.2215/CJN.06000521 PMC 바로가기 [Article Type] Editorial
Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble FormsReview Published on 2021-06-232022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE-2 ACE inhibitors ACE-2 addition Angiotensin receptor blockers ARDS Brain Cardiovascular function Cell cell entry change clinical study complications COVID-19 disease Effects enzyme expressed expression expression level form forms function Genetic Infection intestines kidney lung medication medications membrane-bound MOST much lower organ outcome Patient RAAS SARS-CoV SARS-CoV virus SARS-CoV-2 SARS-CoV-2 virus shedding thought tissue Topic variety virulence with COVID-19 [DOI] 10.3390/ijms22136703 PMC 바로가기 [Article Type] Review